http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-096287-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69ece09bafee7e0c49d1f7951a3faa2c http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_25f9390455395f32eb0c36958716aef2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6869 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6803 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6889 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6855 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6851 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K2-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5517 |
| filingDate | 2014-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-096287-A1 |
| titleOfInvention | PIRROLOBENZODIACEPINS AND CONJUGATES |
| abstract | Conjugated compounds of formula (1) wherein: R² is a remainder of formula (2), where R³⁶ᵃ and R³⁶ᵇ are independently selected from H, F, saturated C₁₋₄ alkyl, C₂₋₃ alkenyl, where alkyl and alkenyl groups they are optionally substituted by a group selected from C alqu alkylamido and C alqu alkyl ester; or, when one of R³⁶ᵃ and R³⁶ᵇ is H, the other is selected from nitrile and a C₁₋₄ alkyl ester; R⁶ and R⁹ are independently selected from H, R, OH, O, SH, SR, NH₂, NHR, NRR, NO₂, Me₃Sn and halo; R⁷ is independently selected from H, R, OH, O, SH, SR, NH₂, NHR, NRR, NO₂, Me₃Sn and halo; And it is selected from formulas (3), (4), (5), (6), (7) and (8); L in a connector connected to a cell binding agent; CBA is the cell binding agent; n is an integer selected within the range of 0 to 48; RA⁴ is a C₁₋₆ alkylene group; either (a) R¹⁰ is H, and R¹¹ is OH, ORA, where RA is C₁₋₄ alkyl; or (b) R¹⁰ and R¹¹ form a double nitrogen-carbon bond between the nitrogen and carbon atoms to which they are attached; or (c) R¹⁰ is H and R¹¹ is OSOᶻM, where z is 2 or 3 and M is a pharmaceutically acceptable monovalent cation; R and R are each independently selected from optionally substituted C alquilo alkyl, C₃₋₂₀ heterocyclyl and C₅₋₂₀ aryl groups, and optionally in relation to the NRR, R and R group, together with the nitrogen atom to which are attached, form an optionally substituted 4, 5, 6 or 7-membered heterocyclic ring; wherein R¹⁶, R¹⁷, R¹⁹, R²⁰, R²¹ and R²² are as defined for R⁶, R⁷, R⁹, R¹⁰, R¹¹ and R², respectively; where Z is CH or N; wherein T and T are independently selected from a single bond or a C₁₋₉ alkylene, whose chain may be interrupted by one or more heteroatoms, for example O, S, N (H), NMe, provided that the number of atoms in the shortest chain of atoms between X and X is 3 to 12 atoms; and X and X are independently selected from O, S and N (H). |
| priorityDate | 2013-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID457444288 http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID456171974 |
Total number of triples: 25.