| abstract |
Claim 1: A compound of the formula (1), wherein A is a compound selected from the group of formulas (2); R¹ is hydrogen or halogen; R² is halogen, cycloalkyl, haloazetidinyl, 6-oxa-1-aza-spiro [3.3] heptyl or alkylsulfonyl; R³ is -OR⁸, pyrrolidinyl, halopyrrolidinyl, hydroxy-pyrrolidinyl, morpholinyl, cycloalkylsulfonyl, alkoxy-azetidinyl, 2-oxa-6-aza-spiro [3.3] heptyl or 2-oxa-7-aza-spiro [3.4] heptyl; R⁴ is hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, haloalkyl, cycloalkyl, hydroxycycloalkyl, alkyl-cycloalkyl, aminocarbonylcycloalkyl, phenyl, phenyl-alkyl, alkyloxetanyl, azetidinyl or aminooxetanyl; R⁵ is hydrogen, alkyl or alkyloxadiazolyl; or R⁴ and R⁵, together with the carbon atom, to which they are attached, form a cycloalkyl; R⁶ is alkyl; R⁷ is alkyl; and R⁸ is haloalkyl, alkoxyalkyl, cycloalkylalkyl, haloalkyl, halophenyl, oxetanyl, oxetanilalquilo, alkyl oxetanilalquilo, tetrahydrofuranyl, tetrahydrofuranylalkyl, alkylsulfonylphenyl, alkylpyrrolidinyl, alkyl pyrrolidinyl, azetidinyl, morpholinyl, tetra-hidropiranilo, pyrrolidinyl, piperidinyl, piperidinyl, alquilpiperidinilalquilo, alkyl -piperidinyl, dialkylaminoalkyl, pyridinylalkyl, halo-oxetanylalkyl, dialkyloxazolyl alkyl, alkyloxazolyl-alkyl, halopyridinyl alkyl or morpholinyl; or a pharmaceutically acceptable salt or ester thereof. |