http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-095350-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7aaea2e6a1d9bdb1c843bfe784e79c9e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-10 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D275-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C259-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D261-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4465 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-416 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D261-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 |
| filingDate | 2014-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f8713201135e75b1448a4deaaf1965f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c433227b5517ab51ea4ee517e8a8118 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8aa1ccd46d0ab32858deddd1e932d84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c01eb0bf807ad9099377cc4fc9945d3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c89fec973639bc17a9ce925603d5c27 |
| publicationDate | 2015-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-095350-A1 |
| titleOfInvention | INHIBITING COMPOUNDS OF A HISTONE DEACETILASE AND PHARMACEUTICAL COMPOSITION CONTAINING THEM |
| abstract | Histone deacetylase (HDAC) inhibitors of formula (1), compositions thereof and methods of use. In the formula, each of the dashed lines indicates a single or double bond, provided that the ring contains one or two double bonds that are not adjacent; R¹ is from C (O) NH (OH) or -N (OH) C (O) R⁵ where R⁵ is hydrogen, lower alkyl or halo-lower alkyl; R² is aryl, heteroaryl or heterocycloalkyl, optionally substituted with 1 to 3 independently selected substituents of halogen, alkyl, cycloalkyl, haloalkyl, hydroxyl, alkoxy and nitrile; and R³ is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl or heteroaralkyl, optionally substituted with 1 to 3 independently selected substituents of halogen, CONRᵇRᶜ, alkyl, alkyl substituted with -NRᵇRᶜ, cycloalkyl, haloalkyl, hydroxyl, alkoxy, alkoxy substituted with -NRᵇRᶜ, aryl, heteroaryl and nitrile; R⁴ is independently halogen, lower alkyl, lower haloalkyl or hydroxyl; x and y are independently 1, 2 or 3, provided that the sum of x + y is £ 4, n is chosen from 0; one; 2 and 3; Rᵇ is H, C₁₋₆ alkyl, aryl or heteroaryl; and Rᶜ is hydrogen or C₁₋₄ alkyl; or Rᵇ and Rᶜ, and the nitrogen to which they are attached, form a heterocycloalkyl group; in Rᵇ and Rᶜ, each C₁₋₆ alkyl, cycloalkyl, aryl, heterocycloalkyl or heteroaryl is unsubstituted or substituted with one or more substituents independently selected from C₁₋₄ alkyl, C₃₋₆ cycloalkyl, aryl, heteroaryl, arylC₁₋ alkyl ₄-, heteroaryl-C₁₋₄-alkyl, halo-C₁₋₄- alkyl, -O-C₁₋₄-alkyl, -O-C₁₋₄-alkyl-phenyl, -C₁₋₄-OH alkyl, -C₁₋₄-O alkyl -C₁₋₄ alkyl, -O-C₁₋₄ haloalkyl, halogen, -OH, -NH₂, -C₁₋₄ alkyl-NH₂, -N (C₁₋₄ alkyl) (C₁₋₄ alkyl), -NH (C₁ alkyl ₋₄), -N (C₁₋₄ alkyl) (C₁₋₄-phenyl alkyl), -NH (C₁₋₄-phenyl alkyl), cyano, nitro, oxo (as substituent for heteroaryl), CO₂H, C (O) O-C₁₋₄ alkyl, CON (C₁₋₄ alkyl) (C₁₋₄ alkyl), CONH (C₁₋₄ alkyl), CONH₂, -NHC (O) (C₁₋₄ alkyl), -NHC (O) (phenyl ), -N (C₁₋₄ alkyl) C (O) (C₁₋₄ alkyl), -N (C₁₋₄ alkyl) C (O) (phenyl), C (O) C₁₋₄ alkyl, C (O) C₁₋₄-phenyl alkyl, C (O) C₁₋₄ haloalkyl, -OC (O) C₁₋₄ alkyl, -SO₂ (C₁₋₄ alkyl), -SO₂ (phenyl), -SO₂ (C₁ haloalkyl ₋₄), -SO₂NH₂, -SO₂NH (C₁₋₄ alkyl), -SO₂NH (phenyl), -NHSO₂ (C₁₋₄ alkyl), -NHSO₂ (phenyl) and -NHSO₂ (C₁₋₄ haloalkyl). |
| priorityDate | 2013-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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