http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-095208-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42e94091a4fc81b8d0237117707cc7ee |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00 |
| filingDate | 2014-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d6a21e7e76ec8120291d2c22227665e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e9ef52f52443e0702a957309dad6971 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7ea70e6bb76fd6d1fef9a56d70a6a39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5bdcb0b25d050d2fa0666be55285a5b1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6990d346908d038d600438f20c09e43e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ecfef658518fe86222d9b319214659a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19be806c09aa95040ef1934246d899e2 |
| publicationDate | 2015-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-095208-A1 |
| titleOfInvention | PIRROLOTRIAZINAS AS INHIBITORS OF THE POTASSIUM ION CHANNEL |
| abstract | The compounds are useful as inhibitors of potassium channel function and for the treatment of arrhythmia, maintaining normal sinus rhythm, of disorders associated with IKᵘʳ- and other disorders mediated by ionic channel function. Claim 1: A compound characterized in that it has the formula (1) or an enantiomer, diastereomer, tautomer or salt thereof, wherein: A is - (CH₂) ₘ-R², -CH (R²⁶) -R², - (CH₂) ₙ₋₁-O-R², - (CH₂) ₙ₋₁-NR²⁵-R², CH (R²⁶) CO₂-R² or - (CH₂) ₙ₋₁-NR²⁵-CO₂-R²; A and R²⁴, together with the nitrogen to which they are attached, combine to form a residue of formula (2) or (3), any of which can be substituted with 0 - 2 R²ᵃ; R¹ is C₁₋₁₀ alkyl substituted with 1-2 -OH, C₁₋₁₀ haloalkyl, C₂₋₁₂ alkenyl, C₃₋₁₀ cycloalkyl, wherein the cycloalkyl can be substituted with 0-2 R¹³; or R¹ is selected from the group of formulas (4), any of which can be substituted with 0-2 R¹³; or R¹ is -C (O) -R¹ᵃ; R¹ᵃ is -NH-phenyl, -NH-C₁₋₆-phenyl alkyl, -NH-C₃₋₆ cycloalkyl, -piperidinyl, piperazinyl or -NH-pyrimidinyl, wherein phenyl, alkyl, cycloalkyl, piperidinyl, piperazinyl or pyrimidinyl replace with 0 - 2 R¹³; R² is phenyl, cyclopentyl, cyclohexyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, piperidinyl, pyridinone, pyrrolidinyl, tetrahydropyran, thiazolyl, imidazolyl, isoxazolyl, oxazolyl, morpholinyl, benzothiazolyl, or which can be substituted for any of 2-tetrahydronaphthalenyl; R²ᵃ; R²ᵃ in each case, is independently H, -OH, F, Cl, Br, l, C₁₋₁₀ alkyl, C₁₋₁₀ alkoxy, C₁₋₁₀ haloalkyl, C₃₋₁₀ cycloalkyl, C₂₋₁₂ alkenyl, C₂₋₁₂ alkynyl, C₃₋₁₀ aryl, 4 to 12 membered heteroaryl, 4 to 12 membered heterocyclyl, 4 to 12 membered heteroaryl-C₁₋₁₀ alkyl, -CN, -NO₂, - (CH₂) ₘ-SO₂R¹⁴, -NR¹⁴SO₂R¹⁴, = O , CONR¹⁴R¹⁴, (CH₂) ₘ-SO₂NR¹⁴R¹⁴, - (CH₂) ₘ-NR¹⁴SO₂R¹⁴, (CH₂) ₙNR¹⁴SO₂NR¹⁴R¹⁴, NR¹⁴SO₂NR¹⁴R¹⁴, -CO₂NR¹⁴R¹⁴, -NR¹⁴CO₂NR¹⁴R¹⁴, NR¹⁴COR¹⁴, -SO₂NR¹⁴COR¹⁴, -SO₂NR¹⁴CONR¹⁴R¹⁴, -NR¹⁴CO₂R¹⁴, -CO₂R¹⁴, NR¹⁴R¹⁴, -NR¹⁴CONR¹⁴R¹⁴, C (= NOR¹⁴) NR¹⁴R¹⁴, -CONR¹⁴OR¹⁴ or -NCOR¹⁴, where the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl can be substituted with 0-2 R¹⁴, and the heteroaryl and heterocyclyl consist of c atoms arbono and 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of N, S or O; R³ is phenyl, pyridinyl, pyrimidinyl, dihydropyran or tetrahydropyran, any of which can be substituted with 0-1 R³ᵃ; R³ᵃ is halo, CN, NH₂, -O-C₁₋₃ alkyl or morpholinyl; R¹³, in each case, is independently H, -OH, F, Cl, Br, I, CN, C₁₋₁₀ alkyl, C₁₋₁₀ alkoxy, C₁₋₁₀ haloalkyl, C₁₋₁₀ cycloalkyl, C₂₋₁₂ alkenyl, C₂ alkynyl ₋₁₂, C₆₋₁₀ aryl, 4 to 12 membered heteroaryl, 4 to 12 membered heterocyclyl, 4 to 12 membered heteroaryl-C₁₋₁₀ alkyl, -CN, -NO₂, - (CH₂) ₘ-SO₂R¹⁴, -NR¹⁴SO₂R¹⁴ , = O, CONR¹⁴R¹⁴, (CH₂) ₘ-SO₂NR¹⁴R¹⁴, - (CH₂) ₘ-NR¹⁴SO₂R¹⁴, - (CH₂) ₙ-NR¹⁴SO₂NR¹⁴R¹⁴, NR¹⁴SO₂NR¹⁴R¹⁴, -CO₂NR¹⁴R¹⁴, -NR¹⁴CO₂NR¹⁴R¹⁴, NR¹⁴CORNC¹⁴R₂R¹⁴R¹⁴R¹⁴R¹⁴R¹⁴R¹⁴R¹⁴R¹⁴R¹⁴R¹⁴R¹⁴R¹⁴R¹⁴R¹⁴¹⁴¹⁴¹⁴¹⁴¹⁴¹⁴¹⁴¹⁴¹⁴¹⁴¹⁴--¹⁴------------------------------------------------------------------------¹⁴¹⁴¹⁴¹⁴----------------------------------------- , NR¹⁴R¹⁴, NR¹⁴CONR¹⁴R¹⁴, NR¹⁴-CO-CO-NR¹⁴R¹⁴, C (= NOR¹⁴) NR¹⁴R¹⁴, -CONR¹⁴OR¹⁴ or -NCOR¹⁴, OR¹⁴, where alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl can be substituted with 0 - 2 R¹⁴ᵃ, and the hetero aryl and heterocyclyl consist of carbon atoms and 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of N, S or O; or R¹³ is SO₂NHP (O) (OH) ₂; R¹⁴, in each case, is independently selected from hydrogen, C₁₋₁₀ alkyl, C₆₋₁₀ cycloalkyl, C₆₋₁₀ aryl, 4-12 membered heteroaryl or 4-12 membered heterocyclyl, wherein the alkyl, cycloalkyl, aryl, heteroaryl and heterocyclyl can be substituted with 0-3 R¹⁴ᵃ, and heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of N, S or O; or alternatively, two R¹⁴ are taken together with the atoms to which they are attached to form a cyclic ring, wherein the cyclic ring can be substituted with 0-1 R¹⁴ᵃ and optionally contains 1, 2, 3 or 4 independently selected heteroatoms of the group consisting of N, S or O; R¹⁴ᵃ, in each case, is independently selected from F, Cl, Br, I, C₁₋₁₀ alkyl, C₁₋₁₀ haloalkyl, C₆₋₁₀ aryl, C₆₋₁₀ cycloalkyl, 4-12 membered heteroaryl, 4 to 12 membered heterocyclyl , F, Cl, Br, I, -CN, -NO₂, -CO₂R²⁶, -CO₂NR²⁴R²⁴, OCF₃, -OR²⁵, = O, -CONR²⁴R²⁴, -COR²⁴, -SO₂R²⁴, -NR²⁴R²⁴, -NR²⁴-CO₂R²⁴, SO₂NR²⁴ SO₂NR²⁴ ₁₋₁₀C₁₋₁₀ alkyl, wherein the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of N, S or O; R²⁴, in each case, is independently selected from hydrogen, C₁₋₁₀ alkyl, C₃₋₆ cycloalkyl or phenyl; or R²⁵, in each case, is independently selected from hydrogen, C₁₋₁₀ alkyl, C₃₋₆ cycloalkyl or phenyl; R²⁶, in each case, is independently selected from hydrogen, C₁₋₁₀ alkyl, C₁₋₁₀-OH alkyl, C₁₋₆ haloalkyl, C₃₋₆ cycloalkyl or phenyl; m is 0 to 4; n is 0 to 4; or n-1 is 2 to 4. |
| priorityDate | 2013-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 42.