http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-095057-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_116c851e729089df9a427027272fa290 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65522 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-353 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 |
| filingDate | 2014-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-095057-A1 |
| titleOfInvention | CROMAN-6-ILOXI-REPLACED CYCLALCANOS AND ITS USE AS PHARMACEUTICAL PRODUCTS |
| abstract | Claim 1: A compound of formula (1), in any of its stereoisomeric forms or a mixture of stereoisomeric forms in any proportion, or a pharmaceutically acceptable salt thereof, wherein Ar is phenyl that is unsubstituted or substituted with one or more R⁰ substituents the same or different; R⁰ is selected from the series consisting of halogen, C₁₋₆ alkyl, C₃₋₇ cycloalkyl, C₃₋₇ cycloalkyl-C₁₋₄- alkyl, HO-, C₁₋₆-O- alkyl, C₃₋₇-O- cycloalkyl and C₃₋₇-C₁₋₄-O- cycloalkyl, and two R⁰ groups attached to adjacent carbon atoms in the Ar ring, together with the carbon atoms that carry them, can form a monounsaturated ring from 5 members to 7 members comprising 0, 1 or 2 equal or different heteroatoms in the ring selected from the series consisting of nitrogen, oxygen and sulfur, and which is unsubstituted or substituted with one or more same or different substituents selected from the series consisting in fluorine and C₁₋₄ alkyl; R¹ is hydrogen or one or more same or different substituents selected from the series consisting of fluorine and C₁₋₄ alkyl; R² is selected from the series consisting of hydrogen, C₁₋₆ alkyl, HO-, C--O- alkyl, C₁₋₆-C (O) -O- alkyl, phenyl-C (O) -O- , Het¹-C (O) -O-, R⁵-N (R⁶) -, R⁷-C (O) -N (R⁸) -, R⁷-S (O) ₂-N (R⁸) -, R⁹-N ( R¹⁰) -C (O) -N (R⁸) - and R⁵-N (R⁶) -C (O) -, wherein the C₁₋₆ alkyl is unsubstituted or substituted with one or more same or different R²⁰ substituents; R³ is selected from the series consisting of hydrogen and C₁₋₆ alkyl, wherein the C₁₋₆ alkyl is unsubstituted or substituted with one or two identical or different substituents selected from the series consisting of C₃₋₇ cycloalkyl, phenyl, HO- and C₁₋₄-O- alkyl; or the groups R² and R³ together are oxo; R⁴ is hydrogen or one or more same or different substituents selected from the series consisting of halogen, C₁₋₄ alkyl and C₁₋₄-O- alkyl; R⁵ and R⁶ are independently selected from each other from the series consisting of hydrogen, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₃₋₇ cycloalkyl, C₆₋₁₀ bicycloalkyl, phenyl, Het¹ and Het², wherein C₁₋₆ alkyl is not substituted or substituted with one or more identical or different R²⁰ substituents, and the C₃₋₇ cycloalkyl, C₆₋₁₀ bicycloalkyl and Het² are all unsubstituted or substituted with one or more same or different R²¹ substituents, and the phenyl and Het¹ are all not substituted or substituted with one or more same or different R²² substituents, or the groups R⁵ and R⁶, together with the nitrogen atom that carries them, form a monocyclic, saturated or partially unsaturated heterocycle, from 4 members to 7 members, which, in addition to the nitrogen atom leading to R⁵ and R⁶, it comprises 0 or 1 additional heteroatom in the ring selected from the series consisting of nitrogen, oxygen and sulfur, and which is unsubstituted or substituted with one or more identical or different substituents R²¹; R⁷ is selected from the series consisting of C₁₋₆ alkyl, C₃₋₇ cycloalkyl, phenyl, Het¹ and Het², wherein the C₁₋₆ alkyl is unsubstituted or substituted with one or more same or different R²⁰ substituents, and the cycloalkyl C₃₋₇ and Het² are all unsubstituted or substituted with one or more same or different R²¹ substituents, and phenyl and Het¹ are all unsubstituted or substituted with one or more same or different R²² substituents; R⁸ is selected from the series consisting of hydrogen and C₁₋₄ alkyl; R⁹ is selected from the series consisting of C₁₋₆ alkyl, C₃₋₇ cycloalkyl, C₃₋₇ cycloalkyl-C₁₋₄- alkyl, phenyl-C₁₋₄ alkyl and Het¹-C₁₋₄ alkyl; R¹⁰ is selected from the series consisting of hydrogen, C₁₋₆ alkyl, C₃₋₇ cycloalkyl, C₃₋₇ cycloalkyl-C₁₋₄- alkyl, phenyl-C₁₋₄ alkyl and Het¹-C₁₋₄ alkyl; R²⁰ is selected from the series consisting of R²⁴, fluorine, HO-, oxo, C₁₋₆-O- alkyl, C₃₋₇-O- cycloalkyl, R³⁰-C (O) -O-, R³⁰-NH-C ( O) -O-, HO-S (O) ₂-O-, (HO) ₂P (O) -O-, (HO) ₂P (O) -O-CH₂-OC (O) -O-, C₁ alkyl ₋₆-S (O) ₙ-, cycloalkyl C₃₋₇-S (O) ₙ, R³¹-N (R³²) -, R³³-C (O) -N (R³²) -, C₁₋₆-S alkyl (O ) ₂-N (R³²) -, R³¹-N (R³²) -C (O) -, R³⁴-OC (O) - and R³¹-N (R³²) -S (O) ₂-; R²¹ is selected from the series consisting of C₁₋₄ alkyl, HO-C₁₋₄ alkyl, R³¹-N (R³²) -C₁₋₄ alkyl, R³⁴-OC (O) -C₁₋₄ alkyl, R²⁴, fluorine, HO-, oxo, C₁₋₆-O- alkyl, C₃₋₇-O- cycloalkyl, R³⁰-C (O) -O-, R³⁰-NH-C (O) -O-, HO-S (O ) ₂-O-, (HO) ₂P (O) -O-, (HO) ₂P (O) -O-CH₂-OC (O) -O-, C₁₋₆-S alkyl (O) ₙ-, cycloalkyl C₃₋₇-S (O) ₙ-, R³¹-N (R³²) -, R³³-C (O) -N (R³²) -, C₁₋₆-S (O) alkyl ₂-N (R³²) -, R³¹ -N (R³²) -C (O) -, R³⁴-OC (O) - and R³¹-N (R³²) -S (O) ₂-; R²² is selected from the series consisting of halogen, C₁₋₄ alkyl, HO-C₁₋₄- alkyl, C₃₋₇ cycloalkyl, HO-, oxo, C₁₋₆-O- alkyl, C₃₋₇-O- cycloalkyl, HO-S (O) ₂-O-, (HO) ₂P (O) -O-, (HO) ₂P (O) -O-CH₂-OC (O) -O-, C₁₋₆-S alkyl (O ) ₙ-, cycloalkyl C₃₋₇-S (O) ₙ-, R³¹-N (R³²) -, R³³-C (O) -N (R³²) -, R³³-OC (O) -N (R³²) -, C₁₋₆-S (O) ₂-N (R³²) -, NC-, R³³-C (O) -, R³¹-N (R³²) -C (O) -, R³⁴-OC (O) - and R³¹ -N (R³²) -S (O) ₂-; R²⁴ is a monocyclic or bicyclic ring, from 3 members to 10 members, which is saturated, partially unsaturated or aromatic and comprises 0, 1, 2, 3 or 4 same or different heteroatoms in the ring selected from the series consisting of nitrogen, oxygen and sulfur, and which is unsubstituted or substituted with one or more same or different R²² substituents; R³⁰ and R³³ are independently selected from each other from the series consisting of C₁₋₆ alkyl, C₃₋₇ cycloalkyl, C₃₋₇ cycloalkyl-, C₁₋₄-phenyl-alkyl and Het¹-C₁₋₄- alkyl; R³¹ and R³² are independently selected from each other from the series consisting of hydrogen, C₁₋₆ alkyl, C₃₋₇ cycloalkyl, C₃₋₇ cycloalkyl-C₁₋₄- alkyl, phenyl-C₁₋₄ alkyl and Het¹-C₁₋₄ alkyl , or the R³¹ and R³² groups, together with the nitrogen atom that carries them, form a monocyclic, saturated, 4-membered to 7-membered heterocycle, which, in addition to the nitrogen atom leading to R³¹ and R³², comprises 0 or 1 additional heteroatom in the ring selected from the series consisting of nitrogen, oxygen and sulfur, and which is unsubstituted or substituted with one or more same or different substituents selected from the series consisting of fluorine and C₁₋₄ alkyl; R³⁴ is selected from the series consisting of hydrogen, C₁₋₆ alkyl, C₃₋₇ cycloalkyl, C₃₋₇ cycloalkyl-C₁₋₄- alkyl, phenyl-C₁₋₄ alkyl and Het¹-C₁₋₄ alkyl; Het¹ is an aromatic, monocyclic, 5-membered or 6-membered heterocycle, comprising 1, 2 or 3 heteroatoms the same or different in the ring selected from the series consisting of nitrogen, oxygen and sulfur, and which is unsubstituted or substituted with one or more identical or different substituents selected from the series consisting of halogen, C₁₋₄ alkyl and C--O- alkyl, unless otherwise specified; Het² is a monocyclic or bicyclic heterocycle, saturated or partially unsaturated, of 4 members to 10 members, comprising 1 or 2 heteroatoms the same or different in the selected ring of the series consisting of nitrogen, oxygen and sulfur; n is selected from the series consisting of 0, 1 and 2, where all the numbers n are independent of each other; p and q are independently selected from each other from the series consisting of 0 and 1; wherein all phenyl groups are unsubstituted or substituted with one or more same or different substituents selected from the series consisting of halogen, C₁₋₄ alkyl and C--O- alkyl, unless otherwise specified; wherein all cycloalkyl and bicycloalkyl groups, regardless of any other substituent that may be present in a cycloalkyl or bicycloalkyl group, may be substituted with one or more same or different substituents |
| priorityDate | 2013-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 50.