http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-094557-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-438 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4436 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4353 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-433 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-422 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4523 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4196 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-433 |
| filingDate | 2014-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56a6cee71eb3caba7409b40676bda0a7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8958d3938eec3c40fee785181573e6e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76531e02ff986a4da01ed4879a415841 |
| publicationDate | 2015-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-094557-A1 |
| titleOfInvention | TIADIAZOL, ANALOGS OF THE SAME, AND METHODS FOR THE TREATMENT OF CONDITIONS RELATED TO SMN DEFICIENCY |
| abstract | Claim 1: A compound, or salt thereof, said compound is represented by the formula (1) wherein A is phenyl which is substituted by 0, 1, 2, or 3 substituents independently selected from C₁₋₄ alkyl, wherein 2 C₁₋₄ alkyl groups can be combined with the atoms to which they are attached to form a 5-6 membered ring and is substituted by 0 or 1 substituents selected from oxo, oxime, hydroxyl, halo-C₁₋ alkyl ₄, dihalo-C₁₋₄ alkyl, trihalo-C₁₋₄ alkyl, C₁₋₄ alkoxy, C₁₋₄ alkoxy-C₃₋₇ alkyl, halo-C halo alkoxy, dihalo-C₁₋₄ alkoxy, trihalo-C₁₋ alkoxy ₄, hydroxyl, cyano, halogen, amino, mono- and di-C₁₋₄amino alkyl, heteroaryl, C₁₋₄ alkyl substituted by hydroxyl, C₁₋₄ alkoxy substituted by aryl, amino, -C (O) NH-C alquilo alkyl ₄-heteroaryl, -NHC (O) -C₁₋₄-heteroaryl alkyl, C₁₋₄-C (O) alkyl NH-heteroaryl, alkyl or C₁₋₄-NHC (O) -heteroaryl, 3-7 membered cycloalkyl, 5-7 membered cycloalkenyl or 5, 6 or 9 membered heterocycle containing 1 or 2 heteroatoms, independently selected from S, O and N, wherein heteroaryl has 5, 6 or 9 ring atoms, 1, 2 or 3 ring heteroatoms selected from N, O and S and substituted by 0, 1 or 2 substituents independently selected from oxo, hydroxyl, nitro, halogen, C₁₋₄ alkyl, C₁₋₄ alkenyl, C₁₋₄ alkoxy, C₃₋₇ cycloalkyl, C₁₋₄-OH alkyl, trihalo-C₁₋₄ alkyl, mono- and di-C₁₋₄amino alkyl, -C (O) NH₂, -NH₂, -NO₂, hydroxy-C₁₋₄-alkyl, hydroxy-C₁₋₄ alkyl, heterocycle of 4-7 members-C₁₋₄-alkyl, amino-C₁₋₄-alkyl and mono- and di-C₁-alkyl ₋₄ amino-C₁₋₄ alkyl; or A is 6-membered heteroaryl having 1-3 ring nitrogen atoms, such 6-membered heteroaryl is substituted by phenyl or a heteroaryl having 5 or 6 ring atoms, 1 or 2 ring heteroatoms independently selected from N, O and S and substituted by 0, 1 or 2 substituents independently selected from C₁₋₄ alkyl, mono- and di-C₁₋₄amino alkyl, hydroxy-C₁₋₄amino alkyl, hydroxy-C₁₋₄ alkyl, amino- C₁₋₄ alkyl and mono- and di-C₁₋₄amino-C₁₋₄ alkyl; or A is bicyclic heteroaryl having 9 to 10 ring atoms and 1, 2, or 3 ring heteroatoms independently selected from N, O or S, such bicyclic heteroaryl is substituted by 0, 1 or 2 substituents independently selected from of oxo, cyano, halogen, hydroxyl, C₁₋₄ alkyl, C₂₋₄ alkenyl, C₂₋₄ alkynyl, C₁₋₄ alkoxy and C alco alkoxy substituted by hydroxyl, C₁₋₄ alkoxy, amino and mono- and di-alkyl C₁₋₄amino; B is a group of the formula (2), wherein m, n and p are independently selected from 0 or 1; R, R¹, R², R³, and R⁴ are independently selected from the group consisting of hydrogen, C₁₋₄ alkyl, such alkyl is optionally substituted by hydroxyl, amino or mono- and di-C₁₋₄amino alkyl; R⁵ and R⁶ are independently selected from hydrogen and fluorine; or R and R³, taken in combination form a fused 5- or 6-membered heterocyclic ring having 0 or 1 additional ring heteroatoms selected from N, O or S; R¹ and R³, taken in combination form a C₁₋₃ alkylene group; R¹ and R⁵, taken in combination form a C₁₋₃ alkylene group; R³ and R⁴, taken in combination with the carbon atom to which they bind, form a spirocyclic C₃₋₆ cycloalkyl; X is CRARB, NR⁷-, or a link; R⁷ is hydrogen, or C₁₋₄ alkyl; RA and RB are independently selected from hydrogen and C₁₋₄ alkyl, or RA and RB, taken in combination, form a divalent C₂₋₅ alkylene group; Z is CR⁸ or N; when Z is N, X is a link; R⁸ is hydrogen or taken in combination with R⁶ form a double bond; or B is a group of the formula (3), where Y is C or O and when Y is O, R¹¹ and R¹² are both absent; p and q are independently selected from the group consisting of 0, 1, and 2; R⁹ and R¹³ are independently selected from hydrogen and C₁₋₄ alkyl; R¹⁰ and R¹⁴ are independently selected from hydrogen, amino, mono- and di-C₁₋₄-alkyl and C₁₋₄-alkyl, such alkyl is optionally substituted by hydroxyl, amino or mono- and di-C₁₋₄-alkyl; R¹¹ is hydrogen, C₁₋₄ alkyl, amino or mono- and di-C₁₋₄amino alkyl; R¹² is hydrogen or C₁₋₄ alkyl; or R⁹ and R¹¹, taken in combination, form a saturated azacycle having 4 to 7 ring atoms that is optionally substituted by 1-3 C₁₋₄ alkyl groups; or R¹¹ and R¹², taken in combination form a saturated azacycle having 4 to 7 ring atoms that is optionally substituted by 1-3 C₁₋₄ alkyl groups. |
| priorityDate | 2013-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 72.