http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-094537-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42e94091a4fc81b8d0237117707cc7ee |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-56 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-455 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 |
| filingDate | 2013-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b9cd8056c3fae80959cc37cce24da04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fc70af1feae94cf3329b8a49f7b00cc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_384ccb851989cdab75986efbf7dd95ec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a69a4c529c951585fa858c0f81b34b1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_751bd0c6a785359b427f906c6bc808bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08c81f63242a871ed8b7e9e02f58297f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f490d9ed99dc195322dc6134027bdff8 |
| publicationDate | 2015-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-094537-A1 |
| titleOfInvention | PIRIDIL COMPOUNDS REPLACED WITH USEFUL ALQUILAMIDE AS MODULATORS OF THE ANSWERS OF IL-12, IL-23 AND / OR IFNa |
| abstract | They are useful for the modulation of IL-12, IL-23 and / or lFNa that act on Tyk-2 to generate inhibition of signal transduction. Claim 1: A compound characterized in that it has the formula (1), or a stereoisomer or a salt thereof pharmaceutically acceptable, wherein R¹ is C₁₋₃ alkyl optionally substituted with 0-7 R¹ᵃ; R¹ᵃ is, in each case, independently hydrogen, deuterium, F, CI, Br, CF₃ or CN; R² is C₁₋₆ alkyl substituted with 0-4 R²ᵃ, C₃₋₆ cycloalkyl substituted with 0-4 R²ᵃ, C₆₋₁₀ aryl substituted with 0-4 R²ᵃ, a 5-14 membered heterocycle containing 1-4 heteroatoms selected from N, O and S, substituted with 0-4 R²ᵃ, NR⁶R⁶ or ORᵇ; R²ᵃ is, in each case, independently hydrogen, = O, halo, OCF₃, CN, NO₂, - (CH₂) ʳORᵇ, - (CH₂) ʳSRᵇ, - (CH₂) ʳC (O) Rᵇ, - (CH₂) ʳC (O ) ORᵇ, - (CH₂) ʳOC (O) Rᵇ, - (CH₂) ʳNR¹¹R¹¹, - (CH₂) ʳC (O) NR¹¹R¹¹, - (CH₂) ʳNRᵇC (O) Rᶜ, - (CH₂) ʳNRᵇC (O) ORᶜ, - NRᵇC (O) NR¹¹R¹¹, -S (O) ₚNR¹¹R¹¹, -NRᵇS (O) ₚRᶜ, -S (O) ₚRᶜ, C₁₋₆ alkyl substituted with 0 - 3 Rᵃ, C halo haloalkyl, - (CH₂) ʳ-carbocycle 3-14 member substituted with 0-1 Rᵃ or - (CH₂) 5-7 membered heterocycle comprising carbon atoms or 1-4 heteroatoms selected from N, O and S (O) ₚ substituted with 0-2 Rᵃ; or one R²ᵃ and another R²ᵃ, together with the atoms to which they are attached, combine to form a fused ring of 5-6 members, wherein the fused ring can be substituted with 0-2 Rᵃ; R³ is - (CH₂) ʳ-3-14 membered carbocycle substituted 0-5 R³ᵃ; R³ᵃ is, in each case, independently hydrogen, = O, halo (F), OCF₃, CF₃, CHF₂, CN, NO₂, - (CH₂) ʳORᵇ, - (CH₂) ʳSRᵇ, - (CH₂) ʳC (O) Rᵇ, - (CH₂) ʳC (O) ORᵇ, - (CH₂) ʳOC (O) Rᵇ, - (CH₂) ʳNR¹¹R¹¹, - (CH₂) ʳC (O) NR¹¹R¹¹, - (CH₂) ʳNRᵇC (O) Rᶜ, - (CH₂) ʳNRᵇC (O) ORᶜ, -NRᵇC (O) NR¹¹R¹¹, -S (O) ₚNR¹¹R¹¹, -NRᵇS (O) ₚRᶜ, -S (O) ₚRᶜ, C₁₋₆ alkyl substituted with 0 - 3 Rᵃ, haloalkyl C₁₋₆, - (CH₂) --3-4 membered carbocycle substituted with 0-3 Rᵃ or - (CH₂) ʳ 5-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O and S (O ) ₚ substituted with 0 - 3 Rᵃ; or two R³ᵃ, together with the atoms to which they are attached, combine to form a fused ring, wherein the ring is selected from phenyl and a 5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, S or O, and that fused phenyl ring can also be substituted with Rᵃ; R⁴ and R⁵ are independently hydrogen, C₁₋₄ alkyl substituted with 0-1 Rᶠ, (CH₂) ʳ-phenyl substituted with 0-3 Rᵈ or - (CH₂) - 5-7 membered heterocycle comprising carbon atoms and 1 - 4 heteroatoms selected from N, O and S (O) ₚ; R⁶ and R¹¹ are, in each case, independently hydrogen, C₁₋₄ alkyl substituted with 0-3 Rᶠ, CF₃, C₃₋₁₀ cycloalkyl substituted with 0-1 Rᶠ, (CH) ʳ-phenyl substituted with 0-3 Rᵈ or ( CH₂) 5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O and S (O) ₚ substituted with 0-3 Rᵈ; Rᵃ is, in each case, hydrogen, F, CI, Br, OCF₃, CF₃, CHF₂, CN, NO₂, - (CH₂) ʳORᵇ, - (CH₂) ʳSRᵇ, - (CH₂) ʳC (O) Rᵇ, - (CH₂ ) ʳC (O) ORᵇ, - (CH₂) ʳOC (O) Rᵇ, - (CH₂) ʳNR¹¹R¹¹, - (CH₂) ʳC (O) NR¹¹R¹¹, - (CH₂) ʳNRᵇC (O) Rᶜ, - (CH₂) ʳNRᵇC (O ) ORᶜ, -NRᵇC (O) NR¹¹R¹¹, -S (O) ₚNR¹¹R¹¹, -NRᵇS (O) Rᶜ, -S (O) Rᶜ, -S (O) ₂Rᶜ, C₁₋₆ alkyl substituted with 0 - 3 Rᶠ, haloalkyl C₁₋₆, - (CH₂) ʳ-3-4-membered carbocycle or - (CH₂) --5-7-heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O and S (O) ₚ substituted with 0-3 Rᶠ; Rᵇ is, in each case, hydrogen, C₁₋₆ alkyl substituted with 0-3 Rᵈ, C₁₋₆ haloalkyl, C₃₋₆ cycloalkyl substituted with 0-2Rᵈ, or - (CH₂) --5-7 membered heterocycle which it comprises carbon atoms and 1-4 heteroatoms selected from N, O and S (O) ₚ substituted with 0-3 Rᶠ or (CH₂) ʳ-phenyl substituted with 0-3 Rᵈ; Rᶜ is C₁₋₆ alkyl substituted with 0-3 Rᶠ, (CH₂) ʳ -C ciclo cycloalkyl substituted with 0-3 Rᶠ or (CH₂) ʳ-phenyl substituted with 0-3 Rᶠ; Rᵈ is, in each case, independently hydrogen, F, CI, Br, OCF₃, CF₃, CN, NO₂, -ORᵉ, - (CH₂) ʳ-C (O) Rᶜ, -NRᵉRᵉ, -NRᵉC (O) ORᶜ, alkyl C₁₋₆ or (CH₂) ʳ-phenyl substituted with 0-3 Rᶠ; Rᵉ is independently selected in each case from hydrogen, C₁₋₆ alkyl, C₃₋₆ cycloalkyl and (CH₂) ʳ-phenyl substituted with 0-3 Rᶠ; Rᶠ is, in each case, independently hydrogen, halo, CN, NH₂, OH, C₃₋₆ cycloalkyl, CF₃, O (C₁₋₆ alkyl) or - (CH₂) --5- membered heteroaryl comprising carbon atoms and 1-4 heteroatoms selected from N, O and S (O) ₚ; p is 0, 1 or 2; and r is 0, 1, 2, 3 or 4. |
| priorityDate | 2013-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 47.