| abstract |
It also provides pharmaceutical compositions that include a compound of formula (1) or pharmaceutically acceptable salts thereof and methods for using these compounds and compositions to treat conditions mediated by one or more isoforms of PI3K, such as PI3Kd. Claim 1: A compound having the structure of formula (1), or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein: A is N or CH; n is 0, 1, 2 or 3; each R¹ is independently halo, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted haloalkyl, substituted or unsubstituted alkoxy, hydroxy, substituted or unsubstituted cycloalkyl, SO₂R¹ʳ or C (O) NR¹ˢR¹ᵗ, where each R¹ʳ, R¹ˢ and R¹ᵗ is independently hydrogen or substituted or unsubstituted alkyl; m is 0, 1, 2 or 3; each R² is independently halo, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted haloalkyl or substituted or unsubstituted alkoxy; R³ is hydrogen or substituted or unsubstituted alkyl; and R⁴ is cyano, CON (R⁴ᵃ) ₂, SO₂-alkyl, halo or haloalkyl, where each R⁴ᵃ is independently hydrogen or substituted or unsubstituted alkyl. |