http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-093598-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d9af4d89807e0db8298692dffeabf875 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D285-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-433 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-433 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4245 |
| filingDate | 2013-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a12a1e81e6f9439f326e78df30eeb97 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c44f78240a216635e942fdb188e428ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69b18f8ba8ab1e9c63ea12a38580247a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52b61478bfad17785095557a62288838 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b2ae38fcb997bdb4e0c7ad41b05b99c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4c35cdcef307d3431cebb55f80dfcf9 |
| publicationDate | 2015-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-093598-A1 |
| titleOfInvention | COMPOUNDS AND THEIR EMPLOYMENT METHODS |
| abstract | Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Methods for employing compounds that inhibit glutaminase in the treatment of cancer are also described herein. Claim 1: A compound of the formula (1) or a pharmaceutically acceptable salt thereof, wherein X is an optionally substituted C₃₋₇ cycloalkylene; each W, Y and Z is independently -S-, -CH =, -O-, -N = or -NH-, provided that for each ring at least one of the groups W, Y and Z is not -CH =; each R¹ and R² is independently -NH₂, -N (R³) -C (O) -R⁴, -C (O) -N (R³) -R⁴, -N (R³) -C (O) -O-R⁴, -N (R³) -C (O) -N (R³) -R⁴ or -N (R³) -C (O) -SR⁴; each R³ is independently hydrogen, C₁₋₆ alkyl or aryl; each R⁴ is independently C₁₋₆ alkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, cycloalkyl, cycloalkylalkyl, heterocyclylalkyl or heterocyclyl, each of which is substituted 0-3 times with R⁵; each R⁵ is independently C₁₋₆ alkyl, C₁₋₆ alkoxy, -O- (C₁₋₆ alkylene) (C₁₋₆ alkoxy), -O-heterocyclyl, C₁₋₆ thioalkoxy, C₁₋₆ haloalkyl, C₃₋₇ cycloalkyl, C₃₋₇ cycloalkylalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, heterocyclyl alkyl, heterocyclyl, cyano, halo, oxo, -OH, -OCF₃, -OCHF₂, -SO₂- (C₁₋₆ alkyl), -NO₂, -N (R⁷) -C (O) - (C₁₋₆ alkyl), -C (O) N (R⁷) ₂, -N (R⁷) S (O) ₁₋₂- (C₁₋₆ alkyl), -S (O) ₂N (R⁷) ₂, -N (R⁷) ₂, - (C₁₋₆ alkylene) -N (R⁷) ₂, wherein said alkyl, C₁₋₆ alkoxy, -O- (C₁₋₆ alkylene) (C₁₋₆ alkoxy) , -O-heterocyclyl, C₁₋₆ thioalkoxy, C₁₋₆ haloalkyl, C₃₋₇ cycloalkyl, C₃₋₇ cycloalkylalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, heterocyclylalkyl, heterocyclyl, -SO₂- (C₁₋₆ alkyl), -NO₂ , -N (R⁷) -C (O) - (C₁₋₆ alkyl), -C (O) N (R⁷) ₂, -N (R⁷) S (O) ₁₋₂- (C₁₋₆ alkyl), -S (O) ₂N (R ) ₂, -N (R⁷) ₂ or (C₁₋₆ alkylene) -N (R⁷) ₂ is optionally substituted 0-3 times with R⁸; or two adjacent R⁵ moieties, taken together with the atoms to which they are attached, form a cycloalkyl or heterocyclyl; each R⁶ is independently hydrogen, fluoro, C₁₋₆ alkyl, -OH, -NH₂, -NH (CH₃), -N (CH₃) ₂ or C₁₋₆ alkoxy; each R⁷ is independently hydrogen or C₁₋₆ alkyl; each R⁸ is independently halo, C₁₋₆ alkyl, C₁₋₆ haloalkyl, -OH, -N (R⁷) ₂ or C₁₋₆ alkoxy, -O- (C₁₋₆ alkylene) (C₁₋₆ alkoxy), CN, NO₂ , -N (R⁷) -C (O) - (C₁₋₆ alkyl), -C (O) N (R⁷) ₂, -N (R⁷) S (O) ₁₋₂ (C₁₋₆ alkyl) or - S (O) ₂N (R⁷) ₂; m is 0, 1 or 2; n is 0, 1 or 2; or is 1, 2 or 3; and p is 1, 2 or 3; provided that (i) when X is unsubstituted cyclopropyl, R¹ and R² are not both -NH₂ or NH-C (O) -phenyl; (ii) X is not substituted cyclobutyl or substituted cyclopentyl; and (iii) when X is unsubstituted cyclopropyl, and m and n are both 1, R¹ and R² are not both NH-C (O) -benzyl. |
| priorityDate | 2012-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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