http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-093503-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1f67dd95fb433cb3458c52756dbd5b4c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2013-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e79ec373f38be079da29849060ea451 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6f2b38e80dd5c8236b860ca2ed1e8492 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3a037633a05f72282e6b9a72ac7fad6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be9055113f192e254881abfc7b3ce29c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_efcafa55c243ab42440130806b77098a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d370a9fee0d68f93ddb02c3e4660b7b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_549c3c6f5ca885c1b0fc66abcaa566d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_491098f4576a38b821d8f1bf7031a899 |
| publicationDate | 2015-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-093503-A1 |
| titleOfInvention | DERIVATIVES OF N- (PIRIDIN-2-IL) PIRIMIDIN-4-AMINA CONTAINING A SULFOXIMINE GROUP |
| abstract | Claim 1: A compound of the general formula (1) wherein R¹ represents a group selected from C alquilo alkyl, C ciclo cycloalkyl, heterocyclyl, phenyl, heteroaryl, phenyl-C₁₋₃ alkyl or heteroaryl-C₁₋₃ alkyl, wherein said group is optionally substituted with one or two or three substituents, identically or differently, selected from the group consisting of hydroxy, cyano, halogen, halo C₁₋₃ alkyl, C alkoxy, C₁₋₃ fluoroalkoxy, -NH₂, alkylamino, dialkylamino, acetylamino, N-methyl-N-acetylamino, cyclic amines, -OP (O) (OH) ₂, -C (O) OH, -C (O) NH₂; R² represents a group selected from the group of formulas (2); R³, R⁴ independently represent each other, a group selected from a hydrogen atom, fluorine atom, chlorine atom, bromine atom, cyano, C₁₋₃ alkyl, C₁₋₃ alkoxy, halo-C₁₋₃ alkyl , C₁₋₃ fluoroalkoxy; R⁵ represents a group selected from a hydrogen atom, cyano, -C (O) R⁹, -C (O) OR⁹, -S (O) ₂R⁹, -C (O) NR¹⁰R¹¹, -P (O) (OR¹²) ₂ , -CH₂OP (OR¹²) ₂, C₁₋₆ alkyl, C₃₋₇ cycloalkyl, heterocyclyl, phenyl, heteroaryl, wherein said C₁₋₆ alkyl group, C₃₋₇ cycloalkyl, heterocyclyl, phenyl or heteroaryl is optionally substituted with one, two or three substituents, identically or differently, selected from halogen, hydroxy, cyano, C₁₋₃ alkyl, C₁₋₃ alkoxy, -NH₂, alkylamino, dialkylamino, acetylamino, N-methyl-N-acetylamino, cyclic amines, halo C₁ alkyl ₋₃, Coro fluoroalkoxy; R⁶, R⁷ independently represent each other, a group selected from a hydrogen atom, fluorine atom, chlorine atom, C₁₋₃ alkyl, C₁₋₃ alkoxy, halo C₁₋₃ alkyl, C₁₋ fluoroalkoxy ₃; R⁸ represents a group selected from a) a C₁₋₆ alkyl group, which is optionally substituted with one or two or three substituents, identically or differently, selected from halogen, hydroxy, -NH₂, alkylamino, dialkylamino, acetylamino, N- methyl-N-acetylamino, cyclic amines, cyano, C₁₋₃ alkyl, halo C₁₋₃ alkyl, Coro fluoroalkoxy, C₁₋₃ alkoxy, C₂₋₃ alkenyl, C₂₋₃ alkynyl, C₃₋₇ cycloalkyl, heterocyclyl, phenyl, heteroaryl, wherein said C₃₋₇ cycloalkyl, heterocyclyl, phenyl or heteroaryl group is optionally substituted with one, two or three substituents, identically or differently, selected from halogen, hydroxy, C₁₋₃ alkyl, C₁₋ alkoxy ₃, -NH₂, alkylamino, dialkylamino, acetylamino, N-methyl-N-acetylamino, cyclic amines, halo-C₁₋₃ alkyl, fluoro-C₁₋₃ alkoxy; b) a C₃₋₇ cycloalkyl group, which is optionally substituted with one or two or three substituents, identically or differently, selected from the group consisting of halogen, hydroxy, -NH₂, alkylamino, dialkylamino, acetylamino, N-methyl -N-acetylamino, cyclic amines, cyano, C₁₋₃ alkyl, halo C₁₋₃ alkyl, Coro fluoroalkoxy, C₁₋₃ alkoxy, C₂₋₃ alkenyl, C₂₋₃ alkynyl; c) a heterocyclyl group, which is optionally substituted with one or two or three substituents, identically or differently, selected from the group consisting of halogen, hydroxy, -NH₂, alkylamino, dialkylamino, acetylamino, N-methyl-N- acetylamino, cyclic amines, cyano, C₁₋₃ alkyl, halo C₁₋₃ alkyl, Coro fluoroalkoxy, C₁₋₃ alkoxy, C₂₋₃ alkenyl, C₂₋₃ alkynyl; d) a phenyl group, which is optionally substituted with one or two or three substituents, identically or differently, selected from the group consisting of halogen, hydroxy, -NH₂, alkylamino, dialkylamino, acetylamino, N-methyl-N- acetylamino, cyclic amines, cyano, C₁₋₃ alkyl, halo-C₁₋₃ alkyl, fluoro-C₁₋₃ alkoxy, C₁₋₃ alkoxy; e) a heteroaryl group, which is optionally substituted with one or two or three substituents, identically or differently, selected from the group consisting of halogen, hydroxy, -NH₂, alkylamino, dialkylamino, acetylamino, N-methyl-N- acetylamino, cyclic amines, cyano, C₁₋₃-alkyl, halo-C₁₋₃ alkyl, fluoro-C₁₋₃ alkoxy, C₁₋₃ alkoxy; f) a phenyl-C₁₋₃ alkyl group, where the phenyl group thereof is optionally substituted with one or two or three substituents, identically or differently, selected from the group consisting of halogen, hydroxy, -NH₂, alkylamino, dialkylamino, acetylamino, N-methyl-N-acetylamino, cyclic amines, cyano C₁₋₃ alkyl, halo-C₁₋₃ alkyl, fluoro-C₁₋₃ alkoxy, C₁₋₃ alkoxy; g) a heteroaryl-C₁₋₃ alkyl group, wherein the heteroaryl group thereof is optionally substituted with one or two or three substituents, identically or differently, selected from the group consisting of halogen, hydroxy, -NH₂, alkylamino, dialkylamino, acetylamino, N-methyl-N-acetylamino, cyclic amines, cyano, C₁₋₃ alkyl, halo-C₁₋₃ alkyl, fluoro-C₁₋₃ alkoxy, C₁₋₃ alkoxy; h) a C₃₋₆ cycloalkyl-C alquilo alkyl group, where the C₃₋₆ cycloalkyl group thereof is optionally substituted with one or two or three substituents, identically or differently, selected from halogen, C₁₋₃ alkyl, alkoxy C₁₋₃, halo-C₁₋₃ alkyl, fluoro-C₁₋₃ alkoxy; i) a heterocyclyl-C₁₋₃ alkyl group, wherein the heterocyclyl group thereof is optionally substituted with one or two or three substituents, identically or differently, selected from halogen, C₁₋₃ alkyl, C₁₋₃ alkoxy, halo- C₁₋₃ alkyl, Coro fluoro-alkoxy; R⁹ represents a group selected from C₁₋₆ alkyl, halo-C₁₋₃ alkyl, C₃₋₇ cycloalkyl, heterocyclyl, phenyl, benzyl or heteroaryl, wherein said group is optionally substituted with one, two or three substituents, identically or differently , selected from halogen, hydroxy, C₁₋₃ alkyl, C₁₋₃ alkoxy, -NH₂, alkylamino, dialkylamino, acetylamino, N-methyl-N-acetylamino, cyclic amines, halo-C₁₋₃ alkyl, fluoro-C₁₋₃ alkoxy ; R¹⁰, R¹¹ independently represent each other, a group selected from hydrogen, C₁₋₆ alkyl, C₃₋₇ cycloalkyl, heterocyclyl, phenyl, benzyl or heteroaryl, wherein said C₁₋₆ alkyl group, C₃₋₇ cycloalkyl, heterocyclyl, phenyl, benzyl or heteroaryl is optionally substituted with one, two or three substituents, identically or differently, selected from halogen, hydroxy, C₁₋₃ alkyl, C₁₋₃ alkoxy, -NH₂, alkylamino, dialkylamino, acetylamino, N-methyl -N-acetylamino, cyclic amines halo-C₁₋₃ alkyl, fluoro-Cxi alkoxy, or R¹⁰ and R¹¹, together with the nitrogen atom to which they are attached, form a cyclic amine; R² represents a group selected from hydrogen, C₁₋₄ alkyl or benzyl; and the enantiomers, diasteromers, salts, solvates or solvate salts thereof. |
| priorityDate | 2012-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 40.