http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-093449-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07e98e102d5c8110695d8c5ef4fa2f49 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1611 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1623 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1652 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5078 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-501 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B05D1-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2077 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1682 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-216 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1694 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5089 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-141 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1676 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-216 |
| filingDate | 2013-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b4acbd3f683552eef26c3a71dbc9e5c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6eeabd564d3a856732427966b845eeb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe3315030459b28bd0093c4afd4cd03d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3739cd9ae587936086c207f45b1e3b60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cfd8e488cdfaab41098ff7fe143e5623 |
| publicationDate | 2015-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-093449-A1 |
| titleOfInvention | NUCLEO-COATING COMPOSITE PHARMACEUTICAL POWDER AND PROCEDURES TO PRODUCE IT |
| abstract | A composite particle that includes a core with at least one carrier material, a layer of fluidizing material on the surface of the core, and an outer layer comprising nanoparticles of a material that can be ingested distributed in at least one matrix forming material. A process for producing the composite particles includes the steps of dry coating the particles with a fluidizing material, preparing a suspension of nanoparticles of a material that can be ingested distributed in a matrix forming material, and fluid bed coating of the particles. Vehicle particles with suspension. The process and products provide rapidly dissolving composite particles that can be used for the administration of poorly water-soluble ingestible materials in suitable dosage forms. The process herein reduces or prevents the agglomeration of particles in suitable dosage forms. The process reduces or prevents the agglomeration of the particles during the manufacture of the composite particles to allow the administration and rapid redispersion of the nanoparticles of the material that can be ingested from a dosage form. Claim 1: A composite particle comprising: a core, and an outer layer comprising nanoparticles of a material that can be ingested and at least one matrix forming material. Claim 2: The composite particle according to claim 1, characterized in that the core is a particle having an average particle size ranging from about 20 mM to about 200 mM. Claim 3: The composite particle according to claim 1, characterized in that the core comprises a material selected from starch, lactose, sucrose, cellulose, cellulose ethers and mixtures thereof. Claim 4: The composite particle according to claim 1, which also comprises a layer of fluidizing material located between the core and the outer layer. Claim 5: The composite particle according to claim 4, characterized in that the fluidizing material is selected from silica, alumina, titanium, carbon black, aluminum and calcium silicate, calcium silicate, magnesium silicate, potassium silicate, silicate of sodium, sodium aluminosilicate, calcium and sodium aluminosilicate, tricalcium silicate, silica airgel, talc, iron oxide, other metal oxides and mixtures thereof. Claim 12: The composite particle according to claim 12, characterized in that at least one polymer is selected from the group comprising hydroxypropylcellulose, hydroxypropylmethylcellulose, polyvinyl alcohol, polyvinylpyrrolidone, copolymers of ammonium methacrylate, ethylcellulose, hydroxymethylcellulose , hydroxyethyl cellulose, methyl cellulose, sodium salt of carboxymethyl cellulose, acacia gum and combinations thereof. Claim 13: The composite particle according to claim 12, characterized in that at least one surfactant is selected from the group comprising sodium dodecylsulfate, dioctylsulfosuccinate, ethylene oxide / propylene oxide copolymers, cetyltrimethylammonium bromide, polyethylene sorbitol esters , sodium alginate, lecithin, sodium lauryl sulfate, monooleate, monolaurate, monostearate, stearyl alcohol, ketostearyl alcohol, tyloxapol, polyethoxylated castor oil, and mixtures thereof. Claim 14: A process for preparing a composite particle, comprising the steps of: preparing a suspension of nanoparticles of a material that can be ingested and at least one matrix forming material; and coating the vehicle particles with the suspension in a fluid bed. Claim 15: The method according to claim 14, characterized in that the carrier particles have an average particle size ranging from about 20 mM to about 200 mM. |
| priorityDate | 2012-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 99.