http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-092951-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C43-164 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K11-02 |
| filingDate | 2013-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57ea6c25023eb6990ca51e00d75e5056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_146384f6bdd645c2660e798ececfef23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52fc988a0a9ed03da6ccd4fe62fdbe54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8c4774c401d974d05270dcf0347bbef9 |
| publicationDate | 2015-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-092951-A1 |
| titleOfInvention | PROCESSES BASED ON ALDEHID ACETALS FOR THE MANUFACTURE OF MACROCICLICAL AND INTERMEDIATE DEPSIPEPTIDES |
| abstract | Method or process for the chemical manufacture of depsypeptides of the formula (1) using an aldehyde acetal intermediate. Claim 1: A method or process for the preparation of a cyclic depsipeptide compound of the formula (1), wherein A¹ is a bivalent fraction of an amino acid with a carboxyl or carbamoyl terminal group, and is attached on its right side at the formula (1) through a carbonyl to the rest of the molecule, or is C₁₋₈ alkanoyl or phosphorylated C₁₋₈ hydroxy-alkanoyl; X is linked through an N of A¹ and is acyl or is absent if A¹ is C₁₋₈ alkanoyl or phosphorylated C₁₋₈ hydroxy-alkanoyl; R² is C₁₋₈ alkyl; R³ is the amino acid side chain; R⁵ is the amino acid side chain; R⁶ is the side chain of the amino acid hydroxy; R⁷ is the side chain of an amino acid; and Y is hydrogen or C₁₋₈ alkyl; or a salt thereof; said method comprising deprotecting a compound of the formula (2) wherein the aldehyde protecting groups Rᵏ and Rˡ are independently of each other unsubstituted or substituted alkyl or together with the two binding O atoms and the carbon atom at that the two O atoms are attached form a ring that is unsubstituted or substituted, Y is as defined for a compound of the formula (1) and X *, A¹ *, R² *, R³ *, R⁵ *, R⁶ * , and R⁷ * correspond to X, A¹, R², R³, R⁵, R⁶, and R⁷ in formula (1), respectively, but with the proviso that the reactive functional groups in these fractions are present in protected form, at least , if they could participate in unwanted side reactions, to give rise to a compound of the formula (1); and, if desired, converting a free compound of the formula (1) into a salt, a salt of a compound of the formula (1) into a different salt of a compound of the formula (1) or the free compound of the formula (1) and / or convert a dehydrated analog and / or five-member analog of a compound of the formula (1) into the corresponding compound of the formula (1). |
| priorityDate | 2012-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.