http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-092607-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f52c68e4149a6c462b850d4e7cc2b2f9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 |
| filingDate | 2013-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f75435b75196c10ca10bcbbc8d83974 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc3e225fc8a0be5c94a616e91415ad28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6998ef9123f3ad61dee7ac0a7a8643e0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13219161966e430a1848b598d9342c9c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88a31374f1e2f025f73b4d61c924fce9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b6b56e034162baf4622d672450b8fc2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb48cb5dec89d5d48398a6031068dda6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de2be72c13e42bfceb28b920cfe1d554 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e1535e1589b9005184299e6778f8b01 |
| publicationDate | 2015-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-092607-A1 |
| titleOfInvention | PIRROLOPIRIMIDINILAMINO-BENZOTIAZOLONAS REPLACED |
| abstract | Substituted pyrrolopyrimidinylamino-benzothiazolone compounds, methods for preparing said compounds, intermediates useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds to make a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative and / or angiogenesis disorder, as the sole agent or in combination with other active ingredients. Claim 1: A compound of the general formula (1), wherein R¹ᵃ represents a hydrogen atom or a halogen atom or a hydroxy-, cyano-, C₁₋₆- alkyl, halo-C₁₋₆ alkyl, C₁ alkoxy ₋₆-, halo C₁₋₆- alkoxy, C₃₋₆ cycloalkyloxy, (3-10 membered heterocycloalkyl) -O-, -NR⁵ᵃR⁵ᵇ, -SCF₃ or -SF₅; R¹ᵇ represents a hydrogen atom or a halogen atom or a hydroxy-, cyano-, C₁₋₆- alkyl, halo C₁₋₆ alkyl, C₁₋₆ alkoxy, C₁₋₆ halo-alkoxy, C₃ cycloalkyloxy group ₋₆, (3-10 membered heterocycloalkyl) -O-, -NR⁵ᵃR⁵ᵇ, -SCF₃ or -SF₅; R¹ᶜ represents a hydrogen atom or a halogen atom or a hydroxy-, cyano-, C₁₋₆- alkyl, halo-C₁₋₆-alkyl, C alco-alkoxy, C₁₋₆-halo-alkoxy, cycloalkyloxy group C₃₋₆-, (3-10 membered heterocycloalkyl) -O-, -NR⁵ᵃR⁵ᵇ, -SCF₃ or -SF₅; Y represents N or CR²ᵃ; Z represents N or CR²ᵇ; with the proviso that no more than one of Y and Z represents N; R²ᵃ represents a hydrogen atom or a halogen atom or a group selected from: C₁₋₆- alkyl, C₂₋₆ alkenyl, C₂₋₆- alkynyl, C₃₋₆- cycloalkyl, heterocycloalkyl of between 3 and 10 members, 4-10-membered heterocycloalkenyl, aryl-, heteroaryl-, halo-C₁₋₃- alkyl, cyano-, - (CH₂) qX- (CH₂) ₚ-R³; wherein said C₁₋₆- alkyl, C₃₋₆- cycloalkyl, 3-10 membered heterocycloalkyl, 4-10 membered heterocycloalkenyl, aryl- or heteroaryl- groups are optionally substituted, identically or differently, with 1, 2 , 3, 4 or 5 R⁴ groups; R²ᵇ represents a hydrogen atom or a halogen atom or a group selected from: C₁₋₆- alkyl, C₂₋₆ alkenyl, C₂₋₆- alkynyl, C₃₋₆- cycloalkyl, heterocycloalkyl of between 3 and 10 members, 4 to 10 membered heterocycloalkenyl, aryl-, heteroaryl-, halo-C₁₋₃ alkyl, cyano-, - (CH₂) qX- (CH₂) ₂-R³; wherein said C₁₋₆- alkyl, C₃₋₆- cycloalkyl, 3-10 membered heterocycloalkyl, 4-10 membered heterocycloalkenyl, aryl- or heteroaryl-optionally groups are substituted, identically or differently, with 1, 2 , 3, 4 or 5 R⁴ groups; X represents a union or a bivalent group that is selected from: -O-, -S-, -S (= O) -, -S (= O) ₂-, -S (= O) - (NR³ᵃ) -, - (NR³ᵃ) -S (= O) -, -C (= O) -, - (NR³ᵃ) -, -C (= O) -O-, -OC (= O) -, -C (= S) -O-, -OC (= S) -, -C (= O) - (NR³ᵃ) -, - (NR³ᵃ) -C (= O) -, - (NR³ᵃ) -C (= O) - (NR³ᵇ) -, -OC (= O) - (NR³ᵃ) -, - (NR³ᵃ) -C (= O) -O-; R³ represents a hydrogen atom or a group selected from C₁₋₆- alkyl, C₃₋₆- cycloalkyl, 3-10 membered heterocycloalkyl, aryl-, heteroaryl-, halo-C₁₋₃- alkyl; wherein said C₁₋₆- alkyl, C₃₋₆-heterocycloalkyl groups of 3-10 members, aryl heteroaryl- optionally are substituted, identically or differently, with 1, 2, 3, 4 or 5 R⁴ groups; R³ᵃ represents a hydrogen atom or a group selected from C₁₋₆- alkyl, C₃₋₆- cycloalkyl, 3-10 membered heterocycloalkyl, aryl-, heteroaryl-, halo-C₁₋₃- alkyl; wherein said C₁₋₆- alkyl, C₃₋₆- cycloalkyl, 3-10 membered heterocycloalkyl groups, heteroaryl aryl- are optionally substituted, identically or differently, with 1, 2, 3, 4 or 5 R⁴ groups; R³ᵇ represents a hydrogen atom or a group selected from C₁₋₆- alkyl, C₃₋₆- cycloalkyl, 3-10 membered heterocycloalkyl, aryl-, heteroaryl-, halo-C₁₋₃ alkyl; wherein said C₁₋₆- alkyl, C₃₋₆- cycloalkyl, 3-10 membered heterocycloalkyl groups, heteroaryl aryl- are optionally substituted, identically or differently, with 1, 2, 3, 4 or 5 R⁴ groups; or R³ together with R³ᵃ or R³ᵇ represents a 3-10 membered heterocycloalkyl group or 4-10 membered heterocycloalkenyl, which are optionally substituted, one or more times, identically or differently, with halo-, hydroxyl-, cyano-; R⁴ represents halo-, hydroxy-, oxo- (O =), cyano-, nitro-, C₁₋₆- alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, haloC₁₋₆ alkyl, C₁₋₆ alkoxy -, halo-C₁₋₆-alkoxy, hydroxy-C₁₋₆-alkyl, Cxi-alkoxy-C₁₋₆-alkyl, halo-C₁₋₆-alkoxy-C₁₋₆-alkyl, R⁵-O-, -C (= O) -R⁵, -C (= O) -O-R⁵, -OC (= O) -R⁵, -N (R⁵ᵃ) -C (= O) -R⁵ᵇ, -N (R⁵ᵃ) -C (= O) -NR⁵ᵇR⁵ᶜ, -NR⁵ᵃR⁵ᵇ, -C (= O) -NR⁵ᵃR⁵ᵇ, R⁵-S-, R⁵-S (= O) -, R⁵-S (= O) ₂-, -N (R⁵ᵃ) -S (= O) -R⁵ᵇ, -S (= O) -NR⁵ᵃR⁵ᵇ, -N (R⁵ᵃ) -S (= O) ₂-R⁵ᵇ, -S (= O) ₂-NR⁵ᵃR⁵ᵇ, -S (= O) (= NR⁵ᵃ) R⁵ᵇ, - S (= O) (= NR⁵ᵃ) R⁵ᵇ or -N = S (= O) (R⁵ᵃ) R⁵ᵇ; R⁵ represents a hydrogen atom, a C₁₋₆- alkyl or C₃₋₆- cycloalkyl group; R⁵ᵃ represents a hydrogen atom, a C₁₋₆- alkyl or C₃₋₆- cycloalkyl group; R⁵ᵇ represents a hydrogen atom, a C₁₋₆- alkyl or C₃₋₆- cycloalkyl group; R⁵ᶜ represents a hydrogen atom, a C₁₋₆- alkyl or C₃₋₆- cycloalkyl group; or R⁵ᵃ and R⁵ᵇ together can form a C₂₋₆ alkylene group, in which optionally a methylene can be replaced by -O-, -C (= O) -, -NH-, or -N (C₁₋₄ alkyl) - ; or R⁵ᵃ and R⁵ᶜ together can form a C₂₋₆ alkylene group, in which optionally a methylene can be replaced by -O-, -C (= O) -, -NH-, or -N (C₁₋₄ alkyl) - ; or R⁵ᵇ and R⁵ᶜ together can form a C₂₋₆ alkylene group, in which optionally a methylene can be replaced by -O-, -C (= O) -, -NH-, or -N (C₁₋₄ alkyl) - ; p represents an integer of 0, 1, 2 or 3; q represents an integer of 0, 1, 2 or 3; or a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture thereof. Claim 15: A compound of general formula (2), (3) or (4) wherein R²ᵃ and R²ᵇ are as defined in any of claims 1 to 7, PG represents a hydrogen atom or a protecting group and LG Represents an outgoing group. |
| priorityDate | 2012-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 34.