http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-092437-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5a15c26ed920bde7a57742b39467c5a4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J21-006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-007 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-0059 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-473 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-423 |
| filingDate | 2013-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f5c32e9bcfd9652b4822ade96f24b67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55a4226c02d70aec29d95133d60398ed http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c031c58e09f1b89a25e36b1a9de3c8ae |
| publicationDate | 2015-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-092437-A1 |
| titleOfInvention | PROCEDURE FOR THE PRODUCTION OF 11-METHYLENE-18-METILESTR-4-EN-3,17-DIONA, USED AS INTERMEDIATE FOR SYNTHESIS OF MOLECULES WITH PHARMACOLOGICAL ACTIVITY |
| abstract | Useful as an intermediate in the synthesis of the progestin compounds Desogestrel and Etonogestrel. Claim 1: A selective reduction of the carbonyl at position 17 of 18-methyl -trtr-5-en-3,11,17-trione 3,3-acetal of formula (1) to give 17-hydroxy-18-methyl-estr-5 -en-3,11-dione 3,3-acetal of formula (2), in which R¹ and R² can be bidentate alkyl radicals C₂₋₄, and the wavy line symbol indicates that the -OH group can have both the configuration a like b, said reduction made using a metal hydride in the presence of cerium trichloride, operating at a temperature between -10 and 40 ° C for a time between 30 minutes and 3 hours, in a solvent consisting of a mixture between less an alcohol chosen from methanol, ethanol, isopropanol and cyclohexanol, and at least a second solvent chosen from ethyl ether, isopropyl ether, tetrahydrofuran, methyltetrahydrofuran, chloroform and methylene chloride. |
| priorityDate | 2012-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.