http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-091976-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6a2cc904b7a14e425d8108729f1d0fa5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c89ce4d9ac03f9acd8ddede1162f94d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-438 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4747 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D419-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4741 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 |
| filingDate | 2013-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-091976-A1 |
| titleOfInvention | HCV NS3 PROTEASA INHIBITORS |
| abstract | Spirocyclic compounds such as hepatitis C virus (HCV) NSR3 protease inhibitors containing a spirocyclic moiety, to uses of such compounds for the treatment of HCV infection. Claim 1: A compound of formula (1) or a pharmaceutically acceptable salt thereof, wherein A is selected from the group consisting of C₁₋₈ alkyl, C₂₋₈ alkenyl, C₂₋₈ alkynyl, internally substituted C₁₋₈ alkyl groups , internally substituted C₂₋₈ alkenyl, internally substituted C₂₋₈ alkynyl, C₃₋₈ cycloalkyl, internally substituted C₃₋₈ cycloalkyl, Si (RA) ₃, Si (RA) ₂ (CH₃), Si (RA) (CH₃) ₂ , Si (CH₃) ₃, aryl and bicyclics of 7, 8, 9 and 10 members, where said groups A Si (RA) ₃, Si (RA) ₂ (CH₃), Si (RA) (CH₃) ₂, Si ( CH₃) ₃, internally substituted C₁₋₈ alkyl, internally substituted C₂₋₈ alkenyl, internally substituted C₂₋₈ alkynyl, internally substituted C₃₋₈ cycloalkyl, aryl and bicyclic contain 0, 1, 2 or 3 heteroatoms independently selected from the group that consists of B, O, S and N, each A aryl is independently selected from the group or consisting of aromatic rings of 5 and 6 members and bicyclic aromatic rings of 7, 8, 9 and 10 members, said A is substituted by 0, 1, 2, 3 or 4 RA substituents; each RA is independently selected from the group consisting of H, F, Cl, Br, I, OH, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ alkoxy, C₁₋₆ alkyl (NH₂), phenyl, naphthyl, C₃₋₈ cycloalkyl, halo (C₁₋₆ alkoxy), -O (C₁₋₆ alkyl), SH, S (C₁₋₆ alkyl), NH₂, -NH (C₁₋₆ alkyl), -N (C₁₋₆ alkyl ) ₂, -C (O) (C₁₋₆ alkyl), -CONH₂, -SO₂NH₂, NO₂, CN, -CF₃, -CHF₂, -CH₂F, -OCHF₂, -OCF₃, -OCH₂F, -SO₂ (C₁₋₆ alkyl ), -S (O) (C₁₋₆ alkyl), - (C₁₋₆ alkyl) S (O) (C₁₋₆ alkyl), -S (O) ₂ (C₁₋₆ alkyl), - (C₁₋ alkyl ₆) S (O) ₂ (C₁₋₆ alkyl), - (C₁₋₆ alkyl) N (C₁₋₆ alkyl) SO₂ (C₁₋₆ alkyl), -N (C₁₋₆ alkyl) SO₂ (C₁₋₆ alkyl ), -SO₂N (C₁₋₆ alkyl) ₂, - (C₁₋₆ alkyl) SO₂N (C₁₋₆ alkyl) ₂, -NHCOO (C₁₋₆ alkyl), -NHCO (C₁₋₆ alkyl), -NHCONH (alkyl C₁₋₆), -CO₂ (C₁₋₆ alkyl), -C (O) N (C₁₋₆ alkyl) ₂, - (al C₀₋₅ alkyl) - (C₃₋₈ cycloalkyl), - (C₀₋₅ alkyl) -O- (C₀₋₅ alkyl) - (C₀₋₅ alkyl), - (C-alkyl) -S- (C₀ alkyl ₋₅) - (C₃₋₈ cycloalkyl), - (C₀₋₅ alkyl) -S (O) ₂- (C₀₋₅ alkyl) - (C₃₋₈ cycloalkyl), internally substituted C₁₋₆ alkyl, C₁₋₆ haloalkyl internally substituted, internally substituted C₁₋₆ alkyl (NH₂), internally substituted C₃₋₈ cycloalkyl, halo (internally substituted C₁₋₆ alkoxy), -O (internally substituted C₁₋₆ alkyl), S (internally substituted C₁₋₆ alkyl) , -NH (internally substituted C₁₋₆ alkyl), -N (internally substituted C₁₋₆ alkyl) ₂, -C (O) (internally substituted C₁₋₆ alkyl), -SO₂ (internally substituted C₁₋₆ alkyl), - S (O) (internally substituted C₁₋₆ alkyl), - (internally substituted C₁₋₆ alkyl) S (O) (internally substituted C₁₋₆ alkyl), -S (O) ₂ (internally substituted C₁₋₆ alkyl), -(to internally substituted C₁₋₆ alkyl) S (O) ₂ (internally substituted C₁₋₆ alkyl), - (internally substituted C₁₋₆ alkyl) N (internally substituted C₁₋₆ alkyl) SO₂ (internally substituted C₁₋₆ alkyl), - N (internally substituted C₁₋₆ alkyl) SO₂ (internally substituted C₁₋₆ alkyl), -SO₂N (internally substituted C₁₋₆ alkyl) ₂, - (internally substituted C₁₋₆ alkyl) SO₂N (internally substituted C₁₋₆ alkyl) ₂ , -NHCOO (internally substituted C₁₋₆ alkyl), -NHCO (internally substituted C₁₋₆ alkyl), -NHCONH (internally substituted C₁₋₆ alkyl), -CO₂ (internally substituted C₁₋₆ alkyl), -C (O) N (internally substituted C₁₋₆ alkyl) ₂, - (internally substituted C₀₋₅ alkyl) - (internally substituted C₃₋₈ cycloalkyl), - (internally substituted C₀₋₅ alkyl) -O- (internally substituted C₀₋₅ alkyl) - (internally substituted C₃₋₈ cycloalkyl), - (C₀ alkyl ₅ internally substituted) S- (internally substituted C₀₋₅ alkyl) - (internally substituted C₃₋₈ cycloalkyl), and - (internally substituted C₀₋₅ alkyl) -S (O) ₂- (internally substituted C₀₋₅ alkyl) - (internally substituted C₃₋₈ cycloalkyl), wherein said RA groups internally substituted C₁₋₆ alkyl, internally substituted C₁₋₆ haloalkyl, internally substituted C₁₋₆ alkyl (NH₂), internally substituted C₃₋₈ cycloalkyl, halo (C₁₋₆ alkoxy internally substituted), -O (internally substituted C₁₋₆ alkyl), S (internally substituted C₁₋₆ alkyl), -NH (internally substituted C₁₋₆ alkyl), -N (internally substituted C₁₋₆ alkyl) ₂, -C (O) (internally substituted C₁₋₆ alkyl), -SO₂ (internally substituted C₁₋₆ alkyl), -S (O) (internally substituted C₁₋₆ alkyl), - (internally substituted C₁₋₆ alkyl) S (O) (internally substituted C₁₋₆ alkyl), -S (O) ₂ (C alkyl ₁₋₆ internally substituted), - (internally substituted C₁₋₆ alkyl) S (O) ₂ (internally substituted C₁₋₆ alkyl), - (internally substituted C₁₋₆ alkyl) N (internally substituted C₁₋₆ alkyl) SO₂ ( internally substituted C₁₋₆ alkyl), -N (internally substituted C₁₋₆ alkyl) SO₂ (internally substituted C₁₋₆ alkyl), -SO₂N (internally substituted C₁₋₆ alkyl) ₂, - (internally substituted C₁₋₆ alkyl) SO₂N (internally substituted C₁₋₆ alkyl) ₂, -NHCOO (internally substituted C₁₋₆ alkyl), -NHCO (internally substituted C₁₋₆ alkyl), -NHCONH (internally substituted C₁₋₆ alkyl), -CO₂ (C₁₋₆ alkyl internally substituted), -C (O) N (internally substituted C₁₋₆ alkyl) ₂, - (internally substituted C₀₋₅ alkyl) (internally substituted C₃₋₈ cycloalkyl), - (internally substituted C₀₋₅ alkyl) -O- (internally substituted C₀₋₅ alkyl) - (C₃₋₈ int cycloalkyl badly substituted), - (internally substituted C₀₋₅ alkyl) -S- (internally substituted C₀₋₅ alkyl) - (internally substituted C₃₋₈ cycloalkyl), and - (internally substituted C₀₋₅ alkyl) -S (O) ₂ - (internally substituted C₀₋₅ alkyl) - (internally substituted C₃₋₈ cycloalkyl) contain 0, 1, 2 or 3 heteroatoms independently selected from the group consisting of B, O, S and N, two RA can be taken, together with the atoms to which they are attached, to form a ring that has three to fifteen atoms in the ring; RA and R² can be taken, together with the atoms to which they are attached, to form a ring having sixteen to twenty one atoms in the ring; RA and R¹ or R⁴ can be taken, together with the atoms to which they are attached, to form a ring having sixteen to twenty one atoms in the ring; J is selected from the group consisting of a direct bond, C₁₋₈ alkylene, or a remainder of the group of formulas (2), wherein said C₁₋₈ alkylene are substituted by 0, 1, 2 or 3 RJ substituents; RJ is selected from the group consisting of H, C₁₋₆ alkyl, internally substituted C₁₋₆ alkyl, S |
| priorityDate | 2012-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID457313432 http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID458394811 |
Total number of triples: 27.