| abstract |
This refers to 5-aminotetrahydroquinolin-2-carboxylic acids, procedures for their preparation, their use for the treatment and / or prevention of diseases as well as their use for the preparation of medicaments for the treatment and / or the disease prevention, especially for the treatment and / or prevention of cardiovascular and cardiopulmonary diseases. Claim 1: Compound of the formula (1) wherein R¹ represents hydrogen or fluorine; L¹ represents ethan-1,2-diyl or 1,4-phenylene; and A represents a group of the formula (2), (3) or (4), in which * indicates the respective point of attachment with the rest of the molecule; L² means straight chain C alcan alkanediyl; L³ means a union, -O-, -CH₂-, -CH₂-CH₂- or -CH = CH-; R² means C₁₋₄ alkyl, which may be substituted up to six times with fluorine, or means C₃₋₆ cycloalkyl, which may be mono- or disubstituted, in the same or different manner, with a moiety selected from the fluorine, difluoromethyl, trifluoromethyl series and C₁₋₄ alkyl, or means a 4- to 6-membered heterocyclyl containing one or two identical or different heteroannular members selected from the series N (R⁴), O, S and S (O) ₂ in which R⁴ represents C₁₋ alkyl ₄ or C₁₋₄ alkylcarbonyl or in the case where N (R⁴) represents an annular nitrogen atom by means of which the mentioned heterocyclyl is linked to the adjacent phenyl group, is not present, or means a 5-membered heteroaryl containing one, two or three equal or different ring heteroatoms selected from the N, O and S series and may optionally be condensed with a phenyl ring, the heteroaryl ring and the optionally condensed phenyl ring being able to e respectively mono or disubstituted star, in the same or different manner with a moiety selected from the fluorine, chlorine, cyano, difluoromethyl, trifluoromethyl, C₁₋₄ alkyl, difluoromethoxy, trifluoromethoxy and C₁₋₄ alkoxy series, or means chlorine; and R³A, R³B, R³C and R³D independently mean each other hydrogen or a substituent selected from the fluorine, chlorine, bromine, cyano, C₁₋₄ alkyl, difluoromethyl, trifluoromethyl, C₁₋₄ alkoxy, difluoromethoxy and trifluoromethoxy series; as well as its salts, solvates and solvates of salts. |