http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-091464-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-422 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 |
| filingDate | 2013-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4cd69c79f853a11844cdb339fd401002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_127263d78bf94629a175af3871b575e0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2ffae7c10b91487e85ca9a9b7880c6b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a86d5f5358ab8e142a5f2e33689d533 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54bfd8f40732e8e974620fd9ab29e2f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29bcff8f0475e1e1dccb67114d48f4bf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b40cf03eb6be9e028b4267d4169d4ac |
| publicationDate | 2015-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-091464-A1 |
| titleOfInvention | BIOCLIC COMPOUNDS OF THIOPHENYLAMIDE |
| abstract | Compositions that include the compounds and methods of using the compounds for type 2 diabetes, atherosclerosis, cancer, steatohepatitis, chronic kidney diseases. They are inhibitors of FABP 4 and / or 5 proteins. Claim 1: Compounds of the formula (1) in which: R¹ and R² together form a -CR¹⁴ = CR¹⁵-CR¹⁶ = CR¹⁷-, -CR¹⁴R¹⁵-O- (CR¹⁶R¹⁷) ₘ-CR¹⁸R¹⁹-, -CR¹⁴R¹⁵- (CR¹⁶R¹⁷) ₘ-O-CR¹⁸R¹⁹, -O-CR¹⁴R¹⁵- (CR¹⁶R¹⁷) ₘ-CR¹⁸R¹⁹-, -CR¹⁴R¹⁵-NR²²-CR¹⁶R¹⁷-CR¹⁸R¹⁹-, -CR¹⁴R¹⁵-S (O) ₂-CR¹⁶R¹⁷ -CR¹⁸R¹⁹-, -CR¹⁴R¹⁵-CR²⁰R²¹- or -CR¹⁴R¹⁵-CR¹⁶R¹⁷- (CR¹⁸R¹⁹) ₚ-CR²⁰R²¹-; R³ is a substituted aryl, substituted heterocycloalkyl or substituted heteroaryl, said substituted aryl, substituted heterocycloalkyl and substituted heteroaryl are substituted by R²³ and may also be substituted by R²⁴ and / or R²⁵; R⁴ is H or alkyl; R⁵ and R⁶ are independently selected from H, alkyl and cycloalkyl; R⁷ is H, alkyl or cycloalkyl; A is NR⁸ or CR⁹R¹⁰; E is NR¹¹ or CR¹²R¹³; R⁸ and R¹¹ are independently selected from H, alkyl and cycloalkyl; R⁹, R¹⁰, R¹² and R¹³ are independently selected from H, halogen, alkyl, haloalkyl and cycloalkyl; or R⁵ and R¹² together with the carbon atoms to which they are attached form a substituted cycloalkyl, substituted aryl, substituted heterocycloalkyl or substituted heteroaryl, said substituted cycloalkyl, substituted aryl, substituted heterocycloalkyl and substituted heteroaryl are substituted by R²⁶ and may also be substituted by R²⁷ and / or R²⁸, but if R⁵ and R¹² together with the carbon atoms to which they are attached form a substituted aryl or substituted heteroaryl, then R⁶ and R¹³ will be absent; or R⁸ and R¹² together with the nitrogen and carbon atoms to which they are attached form a substituted heterocycloalkyl or substituted heteroaryl, said substituted heterocycloalkyl and substituted heteroaryl are substituted by R²⁶ and can also be substituted by R²⁷ and / or R²⁸, but in if R⁸ and R¹² together with the carbon atoms to which they are attached form a substituted heteroaryl, then R¹³ will be absent; or R⁹ and R¹¹ together with the nitrogen and carbon atoms to which they are attached form a substituted heterocycloalkyl or substituted heteroaryl, said substituted heterocycloalkyl and substituted heteroaryl are substituted by R²⁶ and can also be substituted by R²⁷ and / or R²⁸, but in if R⁹ and R¹¹ together with the carbon atoms to which they are attached form a substituted heteroaryl, then R¹⁰ will be absent; or R⁹ and R¹² together with the carbon atoms to which they are attached form a substituted cycloalkyl, substituted aryl, substituted heterocycloalkyl or substituted heteroaryl, said substituted cycloalkyl, substituted aryl, substituted heterocycloalkyl and substituted heteroaryl are substituted by R²⁶ and may also be substituted by R²⁷ and / or R²⁸, but if R⁹ and R¹² together with the carbon atoms to which they are attached form a substituted aryl or substituted heteroaryl, then R¹⁰ and R¹³ will be absent; or R¹⁰ and R¹³ together with the carbon atoms to which they are attached form a substituted cycloalkyl, substituted aryl, substituted heterocycloalkyl or substituted heteroaryl, said substituted cycloalkyl, substituted aryl, substituted heterocycloalkyl and substituted heteroaryl are substituted by R²⁹ and may also be substituted by R³⁰ and / or R³¹, but in case R que and R¹³ together with the carbon atoms to which they are attached form a substituted aryl or substituted heteroaryl, then R⁹ and R¹² will be absent; or R¹⁰ and R¹³ together with the carbon atoms to which they are attached form a double bond; R¹⁴, R¹⁵, R¹⁶, R¹⁷, R¹⁸, R¹⁹, R²⁰, R²¹, R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸, R²⁹, R³⁰ and R³¹ are independently selected from H, oxo, hydroxy, halogen, alkyl, cycloalkyl, haloalkyl, alkoxy, alkoxyalkyl, alkoxycarbonyl and carboxy; or R¹⁶ and R¹⁷ together with the carbon atoms to which they are attached form a cycloalkyl or heterocycloalkyl; or R¹⁴ and R²⁰ together with the carbon atoms to which they are attached form a -CH₂- or -CH₂-CH₂-; R²² is H, alkyl, cycloalkyl or alkoxycarbonyl; m is zero or 1; n is zero or 1; p is zero, 1 or 2; or pharmaceutically acceptable salts. |
| priorityDate | 2012-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 51.