| abstract |
Peptides that have biological and therapeutic activity, which in particular, are lipid dipeptides or tripeptides that are analogs of the KPV and KdPT peptides and that have antimicrobial activity. More precisely, the peptides have an antimicrobial activity that is superior to that of the original lysine-proline-valine and lysine-d-proline-tyrosine tripeptides. The peptides described have the general lipid formula C₁₂₋₁₈-KXZ-NH₂, where K is lysine, X is proline, d-proline, histidine or arginine, Z is optional, and if present, it is valine, threonine, alanine or leucine, and the COOH group at the end is amidated with NH₂. The lipid C₁₂₋₁₈ is preferably a lipid unit that is selected from lauric acid (C₁₂), myristic acid (C₁₄), pentadecanoic acid (C₁₅), palmitic acid (C₁₆) and stearic acid (C₁₈). Methods for using these peptides in the treatment of various lesions, inflammations or infections that are caused by bacteria in the skin or other mucous surfaces of the body, such as the oral cavity. Pharmaceutical composition |