http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-090088-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_96ec3985e3ce9b24614fb87bf51a4f12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2013-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fbc332713a4c85673455d3e895091e0d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_095c328794cf3682f2be1913e5b07d31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ae9357efa859fd9f6fb1eafd965cfe2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf0e420cb02700c114accbc27fe5ecd7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7999ad3e6044acbe38b2290b4469505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e00125f1aabf848e9fc6268b6cc2a3c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a38bf71c788ccf4dde87259f46807614 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_28f81e7eb38be733043795f35b492982 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_28620f60ce77ea1a943bf8de04a1a21a |
| publicationDate | 2014-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-090088-A1 |
| titleOfInvention | IMIDAZOPIRIDAZINAS REPLACED WITH AMINO AS MKNK1 INHIBITORS |
| abstract | Methods for making said compounds. Compositions and pharmaceutical combinations that comprise them. Its use in the manufacture of a pharmaceutical composition that is useful in the treatment or prophylaxis of a disease, particularly of a hyperproliferative disorder and / or a disorder related to angiogenesis, as an individual agent or in combination with other active ingredients. It also provides an intermediate for its synthesis. Claim 1: A compound of general formula (1) wherein: R¹ represents a linear C₂₋₆ alkyl group, a linear C₁₋₆-O-linear C₁₋₆ alkyl, a branched C₃₋₆ alkyl, a C₃₋ cycloalkyl ₆, a linear C₁₋₆ alkyl-C₃₋₆ cycloalkyl or a C₃₋₆ cycloalkyl linear- which is optionally substituted, one or more times, independently of one another, with a substituent selected from: an atom halogen, a group -CN, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₁₀ cycloalkyl which is optionally connected as a spiro, a 3-10 membered heterocycloalkyl which is optionally connected as spiro, aryl, aryl which is optionally substituted one or more times independently of each other with R, heteroaryl, heteroaryl which is optionally substituted one or more times independently of each other with R, -C (= O) N H₂, -C (= O) N (H) R, -C (= O) N (R) R, -C (= O) OH, -C (= O) OR, -NH₂, -NHR, -N (R) R, -N (H) C (= O) R, -N (R) C (= O) R, -N (H) S (= O) R, -N (R) S (= O ) R, -N (H) S (= O) ₂R, -N (R) S (= O) ₂R, -N = S (= O) (R) R, -OH, C₁₋₆- alkoxy, haloalkoxy C₁₋₆-, -OC (= O) R, -OC (= O) NH₂, -OC (= O) NHR, -OC (= O) N (R) R, -SH, C₁₋₆-S alkyl -, -S (= O) R, -S (= O) ₂R, -S (= O) ₂NH₂, -S (= O) ₂NHR, -S (= O) ₂N (R) R; Ring A represents a group of formula (2); where * indicates the point of union of said group with the rest of the molecule; and R³ represents a substituent selected from: a halogen atom, a group -CN, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, -C (= O) R, -C (= O) NH₂, -C (= O) N (H) R, -C (= O) N (R) R, -NH₂, -NHR, -N (R) R, -N (H) C (= O ) R, -N (R) C (= O) R, -N (H) C (= O) NH₂, -N (H) C (= O) NHR, -N (H) C (= O) N (R) R, -N (R) C (= O) NH₂, -N (R) C (= O) NHR, -N (R) C (= O) N (R) R, -N (H) C (= O) OR, -N (R) C (= O) OR, -NO₂, -N (H) S (= O) R, -N (R) S (= O) R, -N (H ) S (= O) ₂R, -N (R) S (= O) ₂R, -N = S (= O) (R) R, -OH, C₁₋₆- alkoxy, C₁₋₆- haloalkoxy, -OC (= O) R, -SH, C₁₋₆-S- alkyl, -S (= O) R, -S (= O) ₂R, -S (= O) ₂NH₂, -S (= O) ₂NHR, - S (= O) ₂N (R) R, -S (= O) (= NR) R; R represents a substituent selected from: a halogen atom, a group -CN, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₁₀ -cycloalkyl, 3-10 membered heterocycloalkyl , aryl, heteroaryl, -C (= O) R, -C (= O) NH₂, -C (= O) N (H) R, -C (= O) N (R) R, -C (= O ) OR, -NH₂, -NHR, -N (R) R, -N (H) C (= O) R, -N (R) C (= O) R, -N (H) C (= O) NH₂, -N (H) C (= O) NHR, -N (H) C (= O) N (R) R, -N (R) C (= O) NH₂, -N (R) C (= O) NHR, -N (R) C (= O) N (R) R, -N (H) C (= O) OR, -N (R) C (= O) OR, -NO₂, - N ( H) S (= O) R, -N (R) S (= O) R, -N (H) S (= O) ₂R, -N (R) S (= O) ₂R, -N = S ( = O) (R) R, -OH, C₁₋₆- alkoxy, C₁₋₆- haloalkoxy, -OC (= O) R, -OC (= O) NH₂, -OC (= O) NHR, -OC ( = O) N (R) R, -SH, C₁₋₆-S- alkyl, -S (= O) R, -S (= O) ₂R, -S (= O) ₂NH₂, -S (= O) ₂NHR, -S (= O) ₂N (R) R, -S (= O) (= NR) R; R and R represent, independently of each other, a substituent selected from: C₁₋₆ alkyl, C₁₋₆ haloalkyl; n represents the integer 0, 1, 2, 3, 4 or 5; or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture thereof. Claim 14: A compound of the general formula (3), wherein A, R³ and n are as defined for the compound of the general formula (1) according to any one of claims 1 to 6 and X represents a leaving group, such as a halogen atom, for example, a chlorine, bromine or iodine atom, or a perfluoroalkylsulfonate group, for example, a trifluoromethylsulfonate group or a nonafluorobutyl sulfonate group. |
| priorityDate | 2012-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.