http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-089796-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8bab34457c0c62aadf06ac0280240a61 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-501 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-433 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-397 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4178 |
| filingDate | 2013-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a7c3ba08a0a523e034deb08917bcb3f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_956b7722698fd7d34857fe9581b3e0dd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe4af25f3ce34a9198eb7a93160e4079 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_459c94093e0aa31410949f8012661b5b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1b15649a7424894c0efbb8fa8c35897 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13c3832259dacdf9757d790a625ae182 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cef6457fdfe556178b525fb8a5469e3f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_baee8d6f149be22b5196b732238f9ade http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eab5b1c629021b18db36bd5f42ce8a60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae69dda12cf66da34c93cf2bc6fb6bb8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4fc19f7444dd4809daa2392a14105661 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa850469744101cfb0ad36eed55d7829 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49a1185f84646406cfcd625ff14f74e8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a245c7c4ad86085c0b1b3dd6720b6022 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a49845d5f23857840d4a563b26ebfe9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50a8a9aae0c8635ef9531ee2569a3df8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8dcb0229a5c2b63b4ef17364380db1f4 |
| publicationDate | 2014-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-089796-A1 |
| titleOfInvention | B-LACTAMIC COMPOUNDS REPLACED WITH AMIDINE, ITS PREPARATION AND USE |
| abstract | B-lactam compounds, their preparation and use. In particular, it relates to b-lactam compounds that are monobactamic derivatives substituted with amidine useful as antimicrobial agents and their preparation. Claim 1: The compound of formula (1) wherein R¹ and R² independently represent hydrogen, aminocarbonyl or C₁₋₄ alkyl, or R¹ and R² together with the carbon atom to which they are attached form a C₃₋₈ cycloalkyl. ; R³ represents - (CH₂) ₘ- (SO₂) OH or -O- (CH₂) ₒ- (SO₂) OH, where myo independently represent each other the integer 0, 1, 2 or 3, and where any group CH₂ contained in the residues that R³ represents may be substituted with one or two C₁₋₄ alkyl residues; X represents CR⁴ or N; R⁴ represents hydrogen or halogen; Z represents an alkyl bond or chain with one, two, three or four carbon atoms, where the alkyl chain can be substituted with one, two, three or four substituents, independently selected from each other from the group consisting of carboxy , aminocarbonyl and C₁₋₄ alkyl, where alkyl in turn may be substituted with a substituent selected from the group consisting of hydroxy, carboxy and aminocarbonyl; Y represents a union, O, NH or S; A represents C₆₋₁₀ aryl or 5-10 membered heteroaryl, where aryl and heteroaryl are substituted with a substituent of the formula (2) or (3), where R¹ᵇ, R²ᵇ, R³ᵇ independently represent hydrogen, amino , hydroxy, C₁₋₄ alkyl, C₁₋₄ alkoxy, C₃₋₆, 4-, 5-, 6- or 7-membered 5- or 6-membered heterocyclyl or heteroaryl, where amino and hydroxy can be substituted with one or two substituents independently selected from each other from the group consisting of carbonyl, C₁₋₄-carbonyl alkyl, mono- or di-C₁₋₄-aminocarbonyl alkyl, and C₁₋₄ alkyl, where alkoxy, heterocyclyl and heteroaryl may be substituted with one, two or three substituents independently selected from each other from the group consisting of halogen, hydroxy, amino, carbonyl, carboxy, C₁₋₄carbonyl alkyl, C₁₋₄ alkoxy, mono- or di-C₁₋₄amino alkyl, mono- or di-alkyl C₁₋₄am inocarbonyl, -NH-CH (= NH), -NH-C (= NH) (NH₂), -C (= NH) CH₃ and C₁₋₄ alkyl, and where alkyl and cycloalkyl may be substituted with one, two or three substituents independently selected from each other from the group consisting of halogen, hydroxy, amino, carbonyl, carboxy, carbonyloxy, aminocarbonyl, carbonylamino, C₁₋₄carbonyl alkyl, C₁₋₄ alkoxy, mono- or di-C₁₋₄amino alkyl, mono - or di-C₁₋₄-aminocarbonyl alkyl, -NH-CH (= NH), -NH-C (= NH) (NH₂), -CH (= NH) CH₃, C₆₋₁₀ aryl, 5- or 6-membered heteroaryl and 5 or 6-membered heterocyclyl, where heteroaryl and heterocyclyl in turn can be substituted with C₁₋₄ alkyl, and where amino in turn can be substituted with 5 or 6-membered heteroaryl, or R²ᵇ and R³ᵇ together with the nitrogen atom to which they are attached form a heterocycle of between 5 and 7 members including one, two or three additional heteroatoms selected from the series N, O and S and R¹ᵇ is like defined above; R⁴ᵇ represents hydrogen, amino, hydroxy, C₁₋₄ alkyl or C₁₋₄ alkoxy, where amino and hydroxy can be substituted with one or two substituents independently selected from each other from the group consisting of C₁₋₄carbonyl, mono- or alkyl di-C₁₋₄-aminocarbonyl and C₁₋₄-alkyl, where alkoxy may be substituted with one, two or three substituents independently selected from each other from the group consisting of halogen, hydroxy, amino, carbonyl, carboxy, alkylcarbonyl, C₁ alkoxy ₋₄, mono- or di-C₁₋₄amino alkyl, mono- or di-C₁₋₄aminocarbonyl alkyl, -NHCH (= NH), -NH-C (= NH) (NH₂), -CH (= NH) CH₃ and C₁₋₄ alkyl, and where alkyl can be substituted with one, two or three substituents independently selected from each other from the group consisting of halogen, hydroxy, amino, carbonyl, carboxy, aminocarbonyl, C₁₋₄carbonyl alkyl, C₁₋ alkoxy ₄, mono- or di-C₁₋₄a alkyl mino, mono- or di-C₁₋₄-aminocarbonyl alkyl, -NH-CH (= NH), -NH-C (= NH) (NH₂), -CH (= NH) CH₃, C₁₋₄ alkyl, Cilo aryl ₋₁₀ and 5- or 6-membered heteroaryl; R⁵ᵇ represents hydrogen or C₁₋₄ alkyl; Q represents a junction, CH₂ or NH; k represents the integer 1 or 2; and * is the residue binding site represented by A, and where aryl and heteroaryl can also be substituted with one or two substituents independently selected from each other from the group consisting of halogen, cyano, amino, hydroxy, C₁₋ alkyl ₄, C₁₋₄ alkoxy, mono- or di-C₁₋₄-alkyl, amino-C₁₋₄-alkyl, hydroxy-C₁₋₄-alkyl or carboxy, where alkyl, alkoxy, alkylamino, aminoalkyl, hydroxyalkyl and carboxy may in turn be substituted with a substituent selected from the group consisting of halogen, C₁₋₄ alkyl and carbonyl; and l represents the integer 0, 1, 2 or 3; and the salts thereof, the solvates thereof and the solvates of the salts thereof. |
| priorityDate | 2012-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 55.