http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-089539-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_648c9679dd9ec36125406a2dafa6bf7e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-807 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02 |
| filingDate | 2012-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-089539-A1 |
| titleOfInvention | METHODS OF FORMATION OF PINACOLIC ESTERS OF ACID 4-CHLORINE-2-FLUORO-3-SUBSTITUTED-PHENYLBORONIC AND ITS METHODS OF USE |
| abstract | The methods include the formation of pinacolic esters of 4-chloro-2-fluoro-3-substituted-phenylboronic acid. The method comprises contacting a 1-chloro-3-fluoro-2-substituted-benzene with an alkyl lithium to form a lithium-1-chloro-3-fluoro-2-substituted-benzene. The lithium-1-chloro-3-substituted-benzene-lithium is contacted with an electrophilic boronic acid derivative to form a 4-chloro-2-fluoro-3-substituted-phenylboronate. The 4-chloro-2-fluoro-3-substituted-phenylboronate is reacted with an aqueous base to form a (4-chloro-2-fluoro-3-substituted-phenyl) trihydroxyborate, the (4-chloro-2-fluoro -3-substituted-phenyl) trihydroxyborate is reacted with an acid to form a 4-chloro-2-fluoro-3-substituted-phenylboronic acid. 4-Chloro-2-fluoro-3-substituted-phenylboronic acid is reacted with 2,3-dimethyl-2,3-butanediol to form pinacolic esters of 4-chloro-2-fluoro-3-substituted-phenylboronic acid. Methods of using 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacolic esters to produce 6- (4-chloro-2-fluoro-3-substituted-phenyl) -4-aminopicolinates are also described. |
| priorityDate | 2011-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6425 http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419544915 |
Total number of triples: 16.