http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-089014-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1e70c0aeade92d7571d955d3b90ea06e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-695 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-0812 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P33-10 |
| filingDate | 2012-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77570819a0a7eb9628da12d3cdaa200a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba1d17ea06247e39dd5eb805a133c53a |
| publicationDate | 2014-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-089014-A1 |
| titleOfInvention | SULFONAMIDE ANTIHELMINTICS |
| abstract | Compositions containing them and their use to treat helminth infections are described. Claim 1: A compound of the formula (1), an N-oxide or salt thereof characterized in that, Q is phenyl or naphthalenyl each optionally substituted with up to 5 substituents independently selected from R⁴ᵃ; or Q is a 5- to 6-membered heteroaromatic ring or an 8 to 11-membered heteroaromatic bicyclic ring system, each ring or ring system contains members of the ring selected from carbon atoms and up to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N and optionally substituted with up to 5 substituents independently selected from R⁴ᵃ in ring members of carbon atoms and R⁴ᵇ in ring members of nitrogen atoms; A is N, CH or CR¹; each R¹ is independently halogen, cyano, nitro, OR⁶, NR⁷ᵃR⁷ᵇ, C (O) R⁸, C (O) OR⁹, C (O) NR¹⁰R¹¹, S (O) ₚR¹² or S (O) ₂NR¹⁰R¹¹; or C₁₋₆ alkyl, C₂₋₆ alkenyl or C₂₋₆ alkynyl, each optionally substituted with substituents selected from the group consisting of halogen, cyano, nitro, OR⁶, NR⁷ᵃR⁷ᵇ, C (O) R⁸, C (O) OR⁹, C (O) NR¹⁰R¹¹, S (O) ₚR¹² and S (O) ₂NR¹⁰R¹¹; or C₃₋₇ cycloalkyl, C₄₋₈ cycloalkylalkyl or C₅₋₇ cycloalkenyl, each optionally substituted with substituents independently selected from the group consisting of halogen, cyano, nitro, C₁₋₄ alkyl, C₁₋₄ haloalkyl, OR⁶ and S (O ) ₚR¹²; R² is hydrogen, cyano, OR⁶, NR⁷ᵃR⁷ᵇ, C (O) R⁸, C (O) OR⁹, C (O) NR¹⁰R¹¹, S (O) ₚR¹² or S (O) ₂NR¹⁰R¹¹; or C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl or benzyl, each optionally substituted with substituents independently selected from the group consisting of halogen, cyano, nitro, OR⁶, NR⁷ᵃR⁷ᵇ, C (O) R⁸, C (O ) OR⁹, C (O) NR¹⁰R¹¹, S (O) ₚR¹² and S (O) ₂NR¹⁰R¹¹; or C₃₋₇ cycloalkyl, C₄₋₈ cycloalkylalkyl or C₅₋₇ cycloalkenyl, each optionally substituted with substituents independently selected from the group consisting of halogen, cyano, nitro, C₁₋₄ alkyl, C₁₋₄ haloalkyl, OR⁶ and S (O ) ₚR¹²; R³ is hydrogen, C (O) R⁸, C (O) OR⁹, C (O) NR¹⁰R¹¹, S (O) ₚR¹², S (O) ₂NR¹⁰R¹¹ or Si (R¹³) ₃; or C₁₋₆ alkyl, C₂₋₆ alkenyl or C₂₋₆ alkynyl, each optionally substituted with substituents selected from the group consisting of halogen, cyano, nitro, OR⁶, NR⁷ᵃR⁷ᵇ, C (O) R⁸, C (O) OR⁹, C (O) NR¹⁰R¹¹, S (O) ₚR¹² and S (O) ₂NR¹⁰R¹¹; or C₃₋₇ cycloalkyl, C₄₋₈ cycloalkylalkyl or C₅₋₇ cycloalkenyl, each optionally substituted with substituents independently selected from the group consisting of halogen, cyano, nitro, C₁₋₄ alkyl, C₁₋₄ haloalkyl, OR⁶, NR⁷ᵃR⁷ᵇ, C (O) R⁸, C (O) OR⁹, C (O) NR¹⁰R¹¹, S (O) ₚR¹² and S (O) ₂NR¹⁰R¹¹; or G; G is a 5- to 6-membered aromatic heterocyclic ring, a 3 to 7-membered non-aromatic heterocyclic ring or an 8 to 11-membered non-aromatic heterocyclic bicyclic ring system, each ring or annular system contains annular members selected from carbon atoms and up to 4 heteroatoms independently selected from atoms of up to 2 O, up to 2 S and up to 4 N, and optionally substituted with up to 5 substituents independently selected from R⁵ᵃ in ring members of carbon atoms and R⁵ᵇ in ring members of nitrogen atoms; each R⁴ᵃ is independently halogen, cyano, nitro, OR⁶, NR⁷ᵃR⁷ᵇ, C (O) R⁸, C (O) OR⁹, C (O) NR¹⁰R¹¹, S (O) ₚR¹² or S (O) ₂NR¹⁰R¹¹; or C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, each optionally substituted from the group consisting of halogen, cyano, nitro, OR⁶, NR⁷ᵃR⁷ᵇ, C (O) R⁸, C (O) OR⁹, C (O ) NR¹⁰R¹¹, S (O) ₚR¹² and S (O) ₂NR¹⁰R¹¹; or C₃₋₇ cycloalkyl, C₄₋₈ cycloalkylalkyl or C₅₋₇ cycloalkenyl, each optionally substituted with substituents independently selected from the group consisting of halogen, cyano, nitro, C₁₋₄ alkyl, C₁₋₄ haloalkyl, OR⁶ and S (O ) ₚR¹²; R⁴ᵇ is cyano, OR⁶, NR⁷ᵃR⁷ᵇ, C (O) R⁸, C (O) OR⁹, C (O) NR¹⁰R¹¹, S (O) ₚR¹² or S (O) ₂NR¹⁰R¹¹; or C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl or benzyl, each optionally substituted with substituents independently selected from the group consisting of halogen, cyano, nitro, OR⁶, NR⁷ᵃR⁷ᵇ, C (O) R⁸, C (O ) OR⁹, C (O) NR¹⁰R¹¹, S (O) ₚR¹² and S (O) ₂NR¹⁰R¹¹; or C₃₋₇ cycloalkyl, C₄₋₈ cycloalkylalkyl or C₅₋₇ cycloalkenyl, each optionally substituted with substituents independently selected from the group consisting of halogen, cyano, nitro, C₁₋₄ alkyl, C₁₋₄ haloalkyl, OR⁶ and S (O ) ₚR¹²; each R⁵ᵃ is independently halogen, cyano, nitro, OR⁶, NR⁷ᵃR⁷ᵇ, C (O) R⁸, C (O) OR⁹, C (O) NR¹⁰R¹¹, S (O) ₚR¹² or S (O) ₂NR¹⁰R¹¹; or C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, each optionally substituted from the group consisting of halogen, cyano, nitro, OR⁶, NR⁷ᵃR⁷ᵇ, C (O) R⁸, C (O) OR⁹, C (O ) NR¹⁰R¹¹, S (O) ₚR¹² and S (O) ₂NR¹⁰R¹¹; or C₃₋₇ cycloalkyl, C₄₋₈ cycloalkylalkyl or C₅₋₇ cycloalkenyl, each optionally substituted with substituents independently selected from the group consisting of halogen, cyano, nitro, C₁₋₄ alkyl, C₁₋₄ haloalkyl, OR⁶ and S (O ) ₚR¹²; each R⁵ᵇ is cyano, OR⁶, NR⁷ᵃR⁷ᵇ, C (O) R⁸, C (O) OR⁹, C (O) NR¹⁰R¹¹, S (O) ₚR¹² or S (O) ₂NR¹⁰R¹¹; or C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl or benzyl, each optionally substituted with substituents independently selected from the group consisting of halogen, cyano, nitro, OR⁶, NR⁷ᵃR⁷ᵇ, C (O) R⁸, C (O ) OR⁹, C (O) NR¹⁰R¹¹, S (O) ₚR¹² and S (O) ₂NR¹⁰R¹¹; or C₃₋₇ cycloalkyl, C₄₋₈ cycloalkylalkyl or C₅₋₇ cycloalkenyl, each optionally substituted with substituents independently selected from the group consisting of halogen, cyano, nitro, C₁₋₄ alkyl, C₁₋₄ haloalkyl, OR⁶ and S (O ) ₚR¹²; each R⁶ is independently hydrogen, C₂₋₆ alkylcarbonyl, C₂₋₆ alkoxycarbonyl, C₂₋₆ alkylaminocarbonyl, C₃₋₈ dialkylaminocarbonyl, C₁₋₆ alkylsulfinyl, C₁₋₆ alkylsulfonyl, C₂₋₆ alkylsulfonyl or C₃₋₆ dialkylaminosulfonyl ; or C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl or benzyl, each optionally substituted with substituents independently selected from the group consisting of halogen, cyano, nitro, C₁₋₆ alkoxy, C₁₋₆ alkylamino, C₂₋ dialkylamino ₈, C₂₋₆ alkylcarbonyl, C₂₋₆ alkoxycarbonyl, C₂₋₆ alkylaminocarbonyl, C₃₋₆ dialkylaminocarbonyl, C₁₋₆ alkylsulfenyl, C₁₋₆ alkylsulfonyl, C₂₋₆ alkylaminosulfonyl and C₃₋₆ dialkylaminosulfonyl or C₃₋ cycloalkyl ₇, C₄₋₈ cycloalkylalkyl or C₅₋₇ cycloalkenyl, each optionally substituted with substituents independently selected from the group consisting of halogen, cyano, nitro, C₁₋₄ alkyl, C₁₋₄ haloalkyl, C₁₋₄ alkoxy, C₁₋₄ alkylsulfenyl , C₁₋₄ alkylsulfinyl and C₁₋₄ alkylsulfonyl; each R⁷ᵃ is independently hydrogen, C₂₋₆ alkylcarbonyl, C₂₋₆ alkoxycarbonyl, alkylaminocar |
| priorityDate | 2011-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 36.