http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-088989-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4375 |
| filingDate | 2012-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aae45015d94cb9933c77f2d5d16295d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91230c7704359fc423e38bc77da18348 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21be27fb26e32f566ccffb1d49694772 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97c16619bdecbaa53da5f9bc40a9d4ef http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4cd69c79f853a11844cdb339fd401002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea2cb7b864622a19fd7f6318f1769420 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_094241f501ec8642104ad27c31173859 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04f9a7294474c2ffcdbb5840d9053015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b4c0e55346ded3e71ce95f6b95f680c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fddafceb5685473ae0d74ce65e105370 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb99ec3db6c078acbf5f4aeabd6610fc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_490e30b350d038d051e46b8038de2470 |
| publicationDate | 2014-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-088989-A1 |
| titleOfInvention | BICYCLE DERIVATIVES OF DIHYDROISOQUINOLIN-1-ONA |
| abstract | The compounds are useful for treating chronic renal diseases hypertension, primary aldosterism and Cushing's syndrome. Claim 1: Compounds of the formula (1) wherein: R¹, R², R³ and R⁴ are independently selected from H, alkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, halocycloalkyl, hydroxyalkyl, alkoxyalkyl, haloalkoxyalkyl, halocycloalkylalkyl, heterocycloalkyl, heterocycloalkyl, heterocycloalkyl, heterocycloalkyl, heterocycloalkyl substituted, substituted arylalkyl and substituted heteroarylalkyl, said substituted heterocycloalkyl, substituted heterocycloalkylalkyl, substituted arylalkyl and substituted heteroarylalkyl are substituted by R¹², R¹³ and R¹⁴; or R² and R⁴ together form a double bond, but in case R² and R⁴ together form a double bond, then R⁵ is H; or R¹ and R² together with the carbon atom to which they are attached form a substituted cycloalkyl or a substituted heterocycloalkyl, said substituted cycloalkyl and substituted heterocycloalkyl are substituted by R²², R²³ and R²⁴; or R³ and R⁴ together with the carbon atom to which they are attached form a substituted cycloalkyl or a substituted heterocycloalkyl, said substituted cycloalkyl and substituted heterocycloalkyl are substituted by R²⁹, R³⁰ and R³¹; or R¹ and R³ together with the carbon atom to which they are attached form a substituted cycloalkyl or a substituted heterocycloalkyl, said substituted cycloalkyl and substituted heterocycloalkyl are substituted by R⁴⁴, R⁴⁵ and R⁴⁶; A¹ is CR⁸ or N; A² is CR⁹ or N; A³ is CR¹⁰ or N; A⁴ is CR¹¹ or N; A⁵ is CR⁶ or N; one of R⁵, R⁶, R⁷ and R⁸ is chosen from halogen, cyano, alkoxy, hydroxyalkoxy, haloalkyl, haloalkoxy and hydroxy and the others are independently selected from each other between H, halogen, cyano, alkoxy, hydroxyalkoxy, haloalkoxy and hydroxy; R⁹ is H, halogen, hydroxy, cyano, alkyl, hydroxyalkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, alkylcycloalkyl, halocycloalkyl, alkylcycloalkylalkyl, alcoxicicloalquilalquilo, halocycloalkylalkyl, cycloalkylalkoxy, cycloalkylalkoxyalkyl, cycloalkoxy, cycloalkoxyalkyl, halocycloalkoxy, halocicloalcoxialquilo, alkylcycloalkoxy, alquilcicloalcoxialquilo, alkoxy, alkoxyalkyl, alcoxicicloalquilalquilo, dialkoxyalkyl, haloalkoxy, haloalkoxyalkyl, alkoxyalkoxy, alkoxyalkoxyalkyl, haloalcoxialcoxi, haloalcoxialcoxialquilo, substituted arylalkyl, arilhidroxialquilo substituted heterocycloalkylalkyl unsubstituted or substituted heteroarylalkyl, said substituted arylalkyl, arilhidroxialquilo substituted heterocycloalkylalkyl substituted and substituted heteroarylalkyl is substituted by R³², R³³ and R³⁴; R¹⁰ is -Oₘ- (CR¹⁵R¹⁶) ₚ- (CR¹⁷R¹⁸) q- (CR¹⁹R²⁰) ʳ-R²¹; or R⁹ and R¹⁰ together with the carbon atoms to which they are attached form a substituted cycloalkyl, a substituted heterocycloalkyl, a substituted aryl or a substituted heteroaryl, said substituted cycloalkyl, substituted heterocycloalkyl, substituted aryl and substituted heteroaryl are substituted by R³⁵, R³⁶ and R³⁷; R¹¹ is H; R¹⁵, R¹⁷ and R¹⁹ are independently selected from H, alkyl, cycloalkyl, haloalkyl and halocycloalkyl; R¹⁶, R¹⁸ and R²⁰ are independently selected from H, hydroxy, halogen and alkyl; or R¹⁵ and R¹⁶ together with the carbon atom to which they are attached form a cycloalkyl; or R¹⁷ and R¹⁸ together with the carbon atom to which they are attached form a cycloalkyl; or R¹⁹ and R²⁰ together with the carbon atom to which they are attached form a cycloalkyl; or R¹⁵ and R¹⁷ together form a - (CH₂) ᵛ-; or R¹⁵ and R¹⁹ together form a - (CH₂) ʷ-; or R¹⁷ and R¹⁹ together form a - (CH₂) ˣ-; R²¹ is H, halogen, cyano, -OR²⁵, -SR²⁵, -S (O) R²⁵, -S (O) ₂R²⁵, -NR²⁵R²⁶, -NR²⁶SO₂R²⁵, -NR²⁶SO₂NR²⁵R²⁷, -NR²⁶C (O) R²⁵, -NR²⁶C -OR - NR²⁵R²⁷, -C (O) R²⁸, -C (O) NR²⁵R²⁶, cycloalkyl, substituted heterocycloalkyl, substituted heteroaryl or substituted aryl, said substituted heterocycloalkyl, substituted heteroaryl, substituted heteroarylalkyl and substituted aryl are substituted by R³⁸, R³⁹ and R⁴⁰; R²⁵ is H, alkyl, hydroxyalkyl, carboxyalkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, alkylcycloalkyl, halocycloalkyl, alkylcycloalkylalkyl, alcoxicicloalquilalquilo, halocycloalkylalkyl, cycloalkylalkoxy-alkyl, cycloalkoxyalkyl, halocicloalcoxialquilo, alquilcicloalcoxialquilo, alkoxyalkyl, haloalkoxyalkyl, alkoxyalkoxyalkyl, haloalcoxialcoxialquilo, heterocycle-substituted alkyl, heterocycloalkylalkyl substituted, substituted heteroaryl, substituted heteroarylalkyl, substituted aryl or substituted arylalkyl, said substituted heterocycloalkyl, substituted heterocycloalkylalkyl, heteroaryl, substituted heteroarylalkyl, substituted aryl and substituted arylalkyl are substituted by R⁴¹, R⁴² and R⁴³; R²⁶ and R²⁷ are independently selected from H, alkyl, cycloalkyl, haloalkyl and halocycloalkyl; or R¹⁵ and R²⁶ together with the nitrogen atom and the carbon atom to which they are attached form a substituted heterocycloalkyl or a substituted heteroaryl, said substituted heterocycloalkyl and substituted heteroaryl are substituted by R⁴⁷, R⁴⁸ and R⁴⁹; or R¹⁷ and R²⁶ together with the nitrogen atom and the carbon atom to which they are attached form a substituted heterocycloalkyl or a substituted heteroaryl, said substituted heterocycloalkyl and substituted heteroaryl are substituted by R⁴⁷, R⁴⁸ and R⁴⁹; or R¹⁹ and R²⁶ together with the nitrogen atom and the carbon atom to which they are attached form a substituted heterocycloalkyl or a substituted heteroaryl, said substituted heterocycloalkyl and substituted heteroaryl are substituted by R⁴⁷, R⁴⁸ and R⁴⁹; R²⁸ is H, hydroxy, alkyl, hydroxyalkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, alkylcycloalkyl, halocycloalkyl, alkylcycloalkylalkyl, alkoxycycloalkyl, halocycloalkylalkyl, cycloalkylalkoxy, cycloalkylalkoxyalkyl, cycloalkoxy, cycloalkoxyalkyl, halocycloalkoxy, halocicloalcoxialquilo, alkylcycloalkoxy, alquilcicloalcoxialquilo, alkoxy, alkoxyalkyl, haloalkoxy, haloalkoxyalkyl, alkoxyalkoxy, alkoxyalkoxy-alkyl, haloalcoxialcoxi, haloalcoxialcoxialquilo, substituted heterocycloalkyl, heterocycloalkylalkyl, substituted heteroaryl, substituted heteroarylalkyl, substituted aryl or substituted arylalkyl, said heterocycloalkyl, substituted heterocycloalkylalkyl, substituted heteroaryl heteroarylalkyl, substituted aryl and substituted aralkyl are substituted by R⁵⁰, R⁵¹ and R⁵²; R¹², R¹³, R¹⁴, R²², R²³, R²⁴, R²⁹, R³⁰, R³¹, R³², R³³, R³⁴, R³⁵, R³⁶, R³⁷, R³⁸, R³⁹, R⁴⁰, R⁴¹, R⁴², R⁴³, R⁴⁴, R⁴⁵, R⁴⁶, R⁴⁷, R⁴⁸, R⁴⁹, R⁵⁰, R⁵¹ and R⁵² are independently selected from H, halogen, hydroxy, amino, nitro, cyano, oxo, alkyl, alkylcarbonyl, alkylsulfonyl, hydroxyalkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, alkylcycloalkyl, halocycloalkyl, alkylcycloalkyl alkyl alkyl alkyl amino, alkylsulfonyl, alkylsulfonylamino, alcoxicicloalquilalquilo, halocycloalkylalkyl, cycloalkylalkoxy, cycloalkylalkoxyalkyl, cycloalkoxy, cycloalkoxyalkyl, halocycloalkoxy, halocicloalcoxialquilo, alkylcycloalkoxy, alquilcicloalcoxialquilo, alkoxy, alkoxycarbonyl, alkoxyalkyl, haloalkoxy, haloalkoxyalkyl, alkoxyalkoxy, alkoxyalkoxyalkyl, haloalcoxialcoxi, halo-alkoxyalkoxyalkyl, cloropiridinilcarbonilo and heterocycloalkyl; n is the number zero or 1; m is the number zero or 1; p, q and r are chosen independently between zero and 1; v and x are independently chosen between 1, 2, 3 and 4; w is the number zero, 1, 2 or 3; with the proviso that no more than two of A², A³ and A⁴ are N; and pharmaceutically acceptable salts thereof. |
| priorityDate | 2011-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.