http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-087915-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-536 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 |
| filingDate | 2012-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_159521585b358f55544fa5b716ce98e0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b26307817dc83f9a5ba830b81b1093c2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_671bd2b5899f3f81654a735b597a76ad |
| publicationDate | 2014-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-087915-A1 |
| titleOfInvention | N- (3- (2-AMINO-6,6-DIFLUOR-4,4A, 5,6,7,7A-HEXAHYDRO-CYCLOPENTA- [E] [1,3] OXAZIN-4-IL) -PENYL) - AMIDAS AS INHIBITORS OF THE BACE1 |
| abstract | The compound, its preparation, pharmaceutical compositions containing them and their use as therapeutically active substances are disclosed. The active compounds herein are useful for therapeutic and / or prophylactic treatment e.g. ex. of Alzheimer's disease, and CNS disorders. Claim 1: A compound of the formula (1), wherein: R¹ is selected from the group consisting of: i) aryl, ii) aryl substituted by 1-4 substituents individually selected from cyano, cyano-C₁₋₆ alkyl, halogen, halogen-C₁₋₆ alkoxy, halogen-C₁₋₆ alkyl, C alco alkoxy, (C₁₋₆ alkoxy) -C₁₋₆ alkyl, (C₂₋₆ alkynyl) -C₁₋₆ alkoxy, C₂₋₆ alkynyl and C₁₋₆ alkyl, iii) heteroaryl and iv) heteroaryl substituted by 1-4 substituents individually selected from (C₃₋₆ cycloalkyl) -C₁₋₆ alkoxy (C₃₋₆ cycloalkyl) -C₁₋₆ alkyl, cyano, cyano-alkyl C₁₋₆, halogen, halogen-C₁₋₆ alkoxy, halogen-C₁₋₆ alkyl, C₁₋₆ alkoxy, (C₁₋₆ alkoxy) -C₁₋₆ alkyl, (C₂₋₆ alkynyl) -C₁₋₆ alkoxy, alkynyl C₂₋₆ and C₁₋₆ alkyl; R² is selected from the group consisting of: i) hydrogen, ii) C₁₋₆ alkyl and iii) halogen; R³ is selected from the group consisting of: i) C₁₋₆ alkyl and ii) halogen-C₁₋₆ alkyl; R⁴ is selected from the group consisting of: i) hydrogen and ii) C₁₋₆ alkyl; and R⁵ is selected from the group consisting of: i) hydrogen, ii) C₁₋₆ alkyl and iii) halogen-C₁₋₆ alkyl; or its pharmaceutically acceptable salts. |
| priorityDate | 2011-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.