abstract |
The present provides anhydrous Aripiprazole B crystals that have low hygroscopicity, where said low hygroscopicity is a moisture content of 0.40% or less after placing said medicinal substance for 24 hours in a dryer, maintained at a temperature of 60 ° C and a 100% humidity level and where said anhydrous Aripiprazole B Crystals have an X-ray diffraction spectrum in powders that have characteristic peaks at 2q: 11.0º, 16.6º, 19.3º, 20.3º and 22, 1st; they have particular infrared absorption bands at 2945, 2812, 1678, 1627, 1448, 1377, 1173, 960 and 779 cm⁻¹ in the IR spectrum (KBr), and exhibit an endothermic peak near approximately 141.5 ° C in an analysis differential thermal / thermogravimetric (heating rate 5ºC / min.), which exhibit an endothermic peak close to approximately 140.7ºC in differential scanning calorimetry (heating rate 5ºC / min.). |