http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-087355-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cef4f341fe4f2caf061611a818576e40 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-212 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-215 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2012-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c4126666ea176c6ad4e57c6ac9f09c7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_423ab00bedc23cc9b3c64e339fe510c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2853ecf5999cb13390fd0253373700af |
| publicationDate | 2014-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-087355-A1 |
| titleOfInvention | DERIVATIVES OF PIRIDIN-2 (1H) -ONA AS JAK INHIBITORS |
| abstract | A process for its preparation, pharmaceutical compositions comprising them and their use in therapy as Janus kinase inhibitors (JAK) are described. Claim 1: A compound of formula (1), or a pharmaceutically acceptable salt, or solvate, or N- oxide, or stereoisomer or deuterated derivative thereof, wherein: m is 0, 1, 2 or 3; each of X and Y independently represents a nitrogen atom or a -CR6 group, wherein at least one of X and Y represents a -CR6 group; each of A and B independently represents a nitrogen atom or a -CR7 group, wherein at least one of A and B represents a -CR7 group; D represents a nitrogen atom or a -CR5 group, where when one of A and B represents a nitrogen atom, D represents a -CR5 group; W represents a linker group selected from a group -NR8-, a group - (CR9R10) -, -O- or -S-; R1 represents a hydrogen atom, a C1-6 linear or branched alkyl group, a C1-4 haloalkyl group, a C1-4 hydroxyalkyl group, a C1-4 alkoxy group, a C3-10 cycloalkyl group, a C3- cycloalkenyl group 10, a C6-14 monocyclic or bicyclic aryl group, a 5-14 membered heteroaryl group containing at least one heteroatom selected from O, S and N, or a 5-14 membered heterocyclic group containing at least one selected heteroatom O, S and N, wherein the cycloalkyl, cycloalkenyl, aryl, heteroaryl and heterocyclyl groups are unsubstituted or substituted with one or more substituents selected from a halogen atom, a cyano group, a C1-6 linear or branched alkyl group , a C1-4 haloalkyl group, a C1-4 hydroxyalkyl group, a C1-4 alkylsulfonyl group, a C3-7 cycloalkyl group, a phenyl group, a pyridyl group, a pyrimidinyl group or a piperidyl group; each of R2 and R7 independently represents a hydrogen atom, a halogen atom, a cyano group, a C1-6 linear or branched alkyl group, a C1-4 haloalkyl group, a C1-4 hydroxyalkyl group, a C3 cycloalkyl group -10, a C3-10 cycloalkenyl group, a C6-14 monocyclic or bicyclic aryl group, a 5 to 14 membered heteroaryl group containing at least one heteroatom selected from O, S and N, a 5 to 14 membered heterocyclic group containing at least one heteroatom selected from O, S and N, or a bicyclic group which is a C6-9 aryl or 5 to 9 membered monocyclic group fused to a 5 to 9 membered cycloalkyl or heterocyclic group, wherein said group heteroaryl or heterocyclic contains at least one heteroatom selected from O, S and N, wherein the cycloalkyl, cycloalkenyl, aryl, heteroaryl and heterocyclyl groups, and the bicyclic group which is a C6-9 aryl monocyclic group or 5-9 membered heteroaryl condensate c on a 5-9 membered cycloalkyl or heterocyclic group, they are unsubstituted or substituted with one or more substituents selected from a halogen atom; a cyano group; a linear or branched C1-6 alkyl group a C1-4 haloalkyl group a C1-4 hydroxyalkyl group a C3-7 cycloalkyl group a C6-14 monocyclic or bicyclic aryl group a 5- to 14-membered heteroaryl group containing at least one heteroatom selected from O, S and N; a 5- to 14-membered heterocyclic group containing at least one heteroatom selected from O, S and N; a group - (CH2) 1-3CN; a group - (CH2) # 11; a group -NR11R12; a group -NR11C (O) - (CH2) n-R12; a group -NR11C (O) - (CH2) n-NR12R13; a group -C (O) - (CH2) 1-3-CN; a group -C (O) - (CH2) n-R11; a group - (CH2) n’-C (O) - (CH2) n-NR11R12; a group - (CH2) n’-S (O) 2 (CH2) nR11; a group - (CH2) n’-S (O) 2 (CH2) nNR11R12; a group -NR11S (O) 2 (CH2) nR12 or a group -NR11S (O) 2 (CH2) nNR12R13; where each n ’and n are 0, 1 or 2; wherein said C6-14 monocyclic or bicyclic aryl group is unsubstituted or further substituted with one or more carboxyl groups; each of R3 and R4 independently represents a hydrogen atom, a C1-4 haloalkyl group, a C1-4 hydroxyalkyl group or a C1-6 linear or branched alkyl group, wherein said alkyl group is unsubstituted or substituted with one or more substituents selected from a C1-4 alkoxy group, a cyano group, a C3-7 cycloalkyl group, a phenyl group, a pyridyl group, a pyrimidinyl group or a piperidyl group; each of R5 and R6 independently represents a hydrogen atom, a halogen atom, a cyano group, a C1-6 linear or branched alkyl group, a C1-4 haloalkyl group, a C1-4 hydroxyalkyl group, a C3 cycloalkyl group -10, a C3-10 cycloalkenyl group, a C6-14 monocyclic or bicyclic aryl group, a 5-14 membered heteroaryl group containing at least one heteroatom selected from O, S and N, or a 5-14 heterocyclic group members containing at least one heteroatom selected from O, S and N, a group - (CH2) nOR11; a group -NR11R12; a group -NR11C (O) - (CH2) n-R12; a group -NR11C (O) - (CH2) n-NR12R13; a group -C (O) - (CH2) 1-3-CN; a group -C (O) - (CH2) n-R11; a group -C (O) - (CH2) n-NR11R12; a group -S (O) 2 (CH2) nR11; a group -S (O) 2 (CH2) nNR11R12; a group -NR11S (O) 2 (CH2) nR12 or a group -NR11S (O) 2 (CH2) nNR12R13; where each n is 0, 1 or 2; wherein the cycloalkyl, cycloalkenyl, aryl, heteroaryl, and heterocyclyl groups are unsubstituted or substituted with one or more substituents selected from a halogen atom, a cyano group, a linear or branched C1-6 alkyl group, a C1- haloalkyl group 4, a C1-4 hydroxyalkyl group, a C3-7 cycloalkyl group, a phenyl group, a pyridyl group, a pyrimidinyl group, a piperidyl group, or a -C (O) - (CH2) n-NR11R12 group; where n is 0, 1 or 2; each of R8, R9 and R10 independently represents a hydrogen atom, a C1-4 haloalkyl group, a C1-4 hydroxyalkyl group or a C1-6 linear or branched alkyl group, wherein said alkyl group is unsubstituted or substituted with one or more substituents selected from a C1-4 alkoxy group, a cyano group, a C3-7 cycloalkyl group, a phenyl group, a pyridyl group, a pyrimidinyl group or a piperidyl group; R11, R12 and R13 each independently represent a hydrogen atom; a C1-4 haloalkyl group a C1-4 hydroxyalkyl group a 5- to 9-membered heterocyclic group containing one, two or three heteroatoms selected from O, S and N, wherein the heterocyclic group is unsubstituted or substituted by one or more substituents selected from a halogen atom, a hydroxyl group, a linear or branched C1-4 alkyl group, a C1-4 haloalkyl group or a C1-4 hydroxyalkyl group, or a linear or branched C1-6 alkyl group, wherein the alkyl group is unsubstituted or substituted by one or more substituents selected from a C1-4 alkoxy group, a cyano group, a C3-7 cycloalkyl group, a phenyl group, a pyridyl group, a pyrimidinyl group or a piperidyl group; wherein the compound of formula (1) is different than: a) 3 - [[5-chloro-2 - [[2,5-dimethyl-4- (piperidin-4-yl) phenyl] amino] pyrimidin-4- il] amino] pyridin-2 (1 H) -one; and b) 2- [7 - [[5-chloro-4 - [(2-oxo-1,2-dihydropyridin-3-yl) amino] pyrimidin-2-yl] amino] -8-methoxy-1,2, 4,5-tetrahydrobenzo [d] azepin-3-yl] -N, N-dimethylacetamide. |
| priorityDate | 2011-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.