http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-087336-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a910d33c239980f3a705e312c5bad6a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4353 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 |
| filingDate | 2012-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2df9243b6a6a367033242ed41e3e555f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2bfae1df6cb2a76ae984d47470f8143b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b66a9189b600c2096923811d344d71b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d9b6919448e74efc8b3a080f3d5b67b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9bd65767374a838b4b8b888648875e21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a4117e71c4c94db246bc66405c55fae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7bb5323694d8bf6a6c1960edd10febc3 |
| publicationDate | 2014-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-087336-A1 |
| titleOfInvention | COMPOUNDS OF 2- (2,4,5-REPLACED ANILINO) PYRIMIDINE |
| abstract | Useful in the treatment or prevention of a medical disease or condition mediated by certain mutated forms of epidermal growth factor receptor (for example the activating mutant L858R, the activating mutant of the Exon19 suppression and the resistance mutant T790M). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. Pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, to intermediates useful in the manufacture of said compounds, and to methods of treating diseases mediated by various different forms of EGFR using said compounds and salts thereof: Claim 1: A compound of formula (1) characterized in that: G is selected from 4,5,6,7-tetrahydropyrazolo [1,5-a] pyridin-3-yl, 1H-indole-3-yl , 1-methyl-1H-indole-3-yl and pyrazolo [1,5-a] pyridin-3-yl; R1 is selected from hydrogen, fluorine, chlorine, methyl and cyano; R2 is selected from methoxy and methyl; and R3 is selected from (3R) -3- (dimethylamino) pyrrolidin-1-yl, (3S) -3- (dimethyl-amino) pyrrolidin-1-yl, 3- (dimethylamino) azetidin-1-yl, [2 - (dimethylamino) ethyl] - (methyl) amino, [2- (methylamino) ethyl] (methyl) amino, 5-methyl-2,5-diazaspiro [3.4] oct-2-yl, (3aR, 6aR) -5 -methylhexa-hydro-pyrrolo [3,4-b] pyrrol-1 (2H) -yl, 1-methyl-1,2,3,6-tetrahydropyridin-4-yl, 4-methylpiperizin-1-yl, 4- [2- (dimethylamino) -2-oxoethyl] piperazin-1-yl, methyl- [2- (4-methylpiperazin-1-yl) ethyl] amino, methyl- [2- (morpholin-4-yl) ethyl] amino , 1-amino-1,2,3,6-tetrahydropyridin-4-yl and 4 - [(2S) -2-aminopropanoyl] piperazin-1-yl; or a pharmaceutically acceptable salt thereof. |
| priorityDate | 2011-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.