http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-087274-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4fda45c540f11df3a7fe71d54a70562a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-436 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4355 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-048 |
| filingDate | 2012-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-087274-A1 |
| titleOfInvention | DERIVATIVES OF AMETAS HETEROCICLICAS AS ANTAGONISTAS OF RECEPTORS P2X7 |
| abstract | Its preparation and its use as pharmaceutically active compounds. Claim 1: A compound of the formula (1), wherein n represents 1 or 2; one of X and Y represents -N- or -N (O) - and the other represents -N- or -C (R6) -; R1 represents hydrogen or methyl and R2 represents hydrogen, C1-2 alkyl, deutero-C1-2 alkyl, hydroxy methyl or heterocyclyl methyl; or R1 and R2 form, together with the carbon atom to which they are attached, a saturated carbocyclic ring of 3 to 6 members; and R3 represents an aryl, an aryloxy, an aryl-C1-2 alkyl, a heteroaryl or a heteroaryloxy group said groups are independently substituted once, twice, three or four times in the aromatic moiety, where the substituents are independently selected from group consisting of C1-3 alkyl, C3-6 cycloalkyl, C1-3 alkoxy, hydroxyC1-2 alkyl, C1-3 fluoroalkyl, C1-3 fluoroalkoxy, C1-2 alkylcarbonyl, cyano, -CONH2, halogen and phenoxy; or R1 represents hydrogen and R2 and R3 form, together with the carbon atom to which they are attached, an indanyl group or a tetrahydronaphthyl group, said groups are in the aromatic moiety independently substituted once, twice or three times, where the substituents are selected independently of the group consisting of C1-3 alkyl, C1-3 fluoroalkyl and halogen; and R4, R5 and R6 independently represent each other hydrogen, C1-3 alkyl, C3-6 cycloalkyl, C1-3 alkoxy, C1-3 fluoroalkyl or halogen; or a salt of said compound. |
| priorityDate | 2011-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.