http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-087273-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_96ec3985e3ce9b24614fb87bf51a4f12 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-0812 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-695 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-695 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 |
| filingDate | 2012-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec1607122ecfbfcb8cd2ba72c7d8a099 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_efb0a72215203a07af8e2dfaa2173574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e444a1bec6095a0712fa5b45a7dc76f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f012db6ac9757a35920931871a0ee48f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9fa5450cb3b081032f6e454f54d76dda http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5132093357a35eb0d70c57cfbe532217 |
| publicationDate | 2014-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-087273-A1 |
| titleOfInvention | 3- (FLUOROVINIL) PIRAZOLES AND ITS USE |
| abstract | Procedures for its preparation, its use for the treatment and / or prevention of diseases as well as its use for the preparation of medicines for the treatment and / or prevention of diseases, especially for the treatment and / or prevention of diseases hyperproliferative and angiogenic as well as those diseases that occur due to a metabolic adaptation to hypoxia states. Such treatments can be carried out as monotherapy or also in combination with other medications or other therapeutic measures. Claim 1: Compound of the formula (1) in which one of the two residues R1A and R1B represents fluorine and the other represents hydrogen; Ar with the substituent R2 represents a phenyl or pyridyl ring of the group of formulas (2), in which * marks the point of attachment with the adjacent CH2 group; R 2 represents hydrogen or a substituent selected from the halogen, cyano, C 1-6 alkyl, C 2-6 alkenyl, C 3-6 cycloalkyl, C 1-6 alkoxy, C 3-6 cycloalkoxy, C 1-4 alkoxycarbonyl, C 1-4 alkylsulfonyl, - NR5R6 and -C (= O) -NR5R6, with C1-6 alkyl being able to be up to trisubstituted with fluorine as well as up to disubstituted, in the same or different manner, with a moiety selected from the hydroxy series, C1-4 alkoxy, alkylcarbonyloxy C1-4 and C3-6 cycloalkyl and the cycloalkyl groups mentioned in turn may be up to the same or differently disubstituted, with a moiety selected from the fluorine series, C1-4 alkyl, trifluoromethyl, hydroxy, hydroxymethyl, C1- alkoxy 4 and C1-4 alkylcarbonyloxy, and in which R5 and R6 independently of each other mean hydrogen, C1-6 alkyl or C3-6 cycloalkyl or R5 and R6 are linked together and together with the nitrogen atom to which they are attached form a 4-6 membered heterocycle, which may contain another heteroatom of the series N, O, S or S (O) 2 and which may be up to the same or differently disubstituted, with a moiety selected from the fluorine, cyano, hydroxy, C1-4 alkoxy, oxo, C1-4 alkyl and cycloalkyl series C3-6, C1-4alkyl may in turn be up to trisubstituted with fluorine; R3 represents a substituent selected from the halogen, cyano, pentafluoroth, C1-4 tri-alkylsilyl, C1-6 alkyl, -NR7R8, -OR8, -SR8, -S (O) 2-R8, C3-6 cycloalkyl and heterocyclyl series 4 to 6 members, C1-6 alkyl may in turn be substituted with a moiety selected from the amino series, -NR7R8, hydroxy, -OR8, C3-6 cycloalkyl and 4-6 membered heterocyclyl as well as substituted six times with fluorine and the cycloalkyl and heterocyclyl groups mentioned in turn may even be disubstituted, in the same or different manner, with a moiety selected from the fluorine series, C1-4 alkyl, trifluoromethyl, hydroxy and C1-4 alkoxy, and in which R7 means hydrogen or C1-4 alkyl and R8 means C1-6 alkyl or C3-6 cycloalkyl, and C1-6 alkyl may be substituted with a moiety selected from the hydroxy series, C1-4 alkoxy, -NR9R10 and - C (= O) -NR9R10 as well as even trisubstituted with fluorine, in which R9 and R10 independently of each other represent hydrogen or C1-4alkyl or are linked together and together with the nitrogen atom, to which they are attached, form a pyrrolidine, piperidine or morpholine ring; and A represents N or C-R4 in which R4 means hydrogen, fluorine, chlorine, cyano, methyl, trifluoromethyl or methoxy; as well as its salts, solvates and solvates of salts. |
| priorityDate | 2011-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 75.