http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-086672-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_41a639aa11b9b2f8063a3e6b8b22b557 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_700ff9a01db2075489cb7ed87392dc28 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-26 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-482 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-19 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16 |
| filingDate | 2012-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1032d1de33d7a0281eb288bdb8743fcf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e2e4d7f2a5cdbd7342bbb5972867034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f116e117cc048b6b9e0a1d95a00d71c2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bfba3bb78fbf0a7f07459284f3cd75dc |
| publicationDate | 2014-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-086672-A1 |
| titleOfInvention | RECOMBINANT FURINA FORMULATIONS |
| abstract | Furin formulations (e.g., rFurina) stabilized containing a sugar, sugar alcohol and / or non-ionic surfactant. Methods for diluting furin compositions (eg rFurina) are provided. Claim 1: A stabilized recombinant furin (rFurina) aqueous composition, wherein the composition comprises: (a) between 8,000 U / mL and 500,000 U / mL of rFurina ; (b) between 100 mM and 300 mM of a pharmaceutically acceptable salt; (c) between 0.5 mM and 2 mM calcium; (d) between 2% and 20% sugar or sugar alcohol; (e) between 10 and 200 ppm of non-ionic surfactant; (f) between 10 and 200 mM of buffering agent; and (g) at pH between 5.5 and 7.5. Claim 12: The composition according to any one of claims 1 to 11, wherein the sugar or sugar alcohol is selected from the group consisting of sucrose, trehalose, mannitol, and a combination thereof. Claim 18: The composition according to any one of claims 1 to 17, wherein the nonionic surfactant is polysorbate-80. Claim 42: An stabilized recombinant furin (rFurina) aqueous composition, wherein the composition comprises: (a) between 8,000 U / mL and 500,000 U / mL of rFurina; (b) 190 mM sodium chloride; (c) 0.92 mM calcium; (d) 10% trehalose; (e) 75 ppm polysorbate 80; (f) 45 mM acetic acid; (g) 46 mM HEPES; and (h) a pH between 5.5 and 7.5. |
| priorityDate | 2011-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 64.