http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-085392-A1
Outgoing Links
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| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4164 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-16 |
| filingDate | 2012-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88c1c29c0c4415c1de3feb9f6e7c8d11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e3b93da9114007ab24f8153443e7fd1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_183abd09c014c1fc8e930a92fe71e5a1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_558ba8d53db5ddec708ce9936922962c |
| publicationDate | 2013-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-085392-A1 |
| titleOfInvention | SUBSTITUTED AROMATIC SULFUR COMPOUNDS AND METHODS FOR USE IN CANCER TREATMENT AND PREVENTION |
| abstract | Together with pharmaceutical compositions and methods for using compounds of formula (1) to treat or reduce the risk of a patient developing peritoneal carcinomatosis. Claim 1: A compound of formula (1), or a pharmaceutically acceptable salt form thereof, wherein: D is a compound of formulas (2), (3), (4), (5) or (6); n is 0, 1 or 2; Ra is hydrogen, alkyl or phenyl; Rb is hydrogen, cyano, alkyl, phenyl, carbamoyl or alkoxycarbonyl; Rc is hydrogen, cyano, alkyl, phenyl, carbamoyl or alkoxycarbonyl; A1 and A2 are, independently, hydrogen, or a remainder of the group of formulas (7), where Q is O or S; R1 and R2 are each independently substituted or unsubstituted alkyl, or R1 and R2, together with the carbon atom to which they are attached, form a substituted or unsubstituted cycloalkyl ring of three to seven members, or R1 and R2, together with the carbon atom to which they are attached, form a substituted or unsubstituted heterocycloalkyl group; R3 is -OH, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocycloalkyl. substituted or unsubstituted heterocycloalkylalkyl; or -NR4R5; R4 and R5 are each independently H, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkylene oxide, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted aryl or unsubstituted, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroaralkyl, -COO-alkyl, -CO-alkyl, -CO-cycloalkyl, - NHCO-alkyl, -NHCO-aryl or -NHCO-cycloalkyl ; or R4 and R5, together with the atoms through which they are linked, form a substituted or unsubstituted heterocycloalkyl ring; R6 is substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, or substituted or unsubstituted heteroaralkyl; Rd is substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, or substituted or unsubstituted heteroaralkyl; Re and Rf are independently substituted or unsubstituted alkyl, or Re and Rf, together with the carbon atom to which they are attached, form a substituted or unsubstituted cycloalkyl ring of three to seven members, or Re and Rf, together with the atom carbon to which they are attached, form a substituted or unsubstituted heterocycloalkyl group; Rg is -OH, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocycloalkyl, substituted heterocycloalkylalkyl not substituted; or -NR4R5; and Rh is H, substituted or unsubstituted alkyl, or substituted or unsubstituted phenyl; provided that one of A1 or A2 is not hydrogen; and also provided that when D is the remainder of formula (2), n is 2, and Ra, Rc and A1 are hydrogen, and Rb is cyano, then A2 will not be tert-butyl. |
| priorityDate | 2011-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.