http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-084779-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6572ff5df928fd17340eb2a8cb6d8502 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-10 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-165 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-25 |
| filingDate | 2012-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7347909417d750a3fa52ee8724d0f4b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c857882d45c3bd227c20b71de42b6e00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95e1177f3d0c2e49dc8ca5cec3a55100 |
| publicationDate | 2013-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-084779-A1 |
| titleOfInvention | AGOMELATINE SYNTHESIS PROCEDURE |
| abstract | Claim 1: Industrial synthesis process of the compound of formula (1) characterized in that the 1- (4-methoxyphenyl) -4-penten-1-one of formula (2) is reacted with a compound of formula (3) in the presence of a radical primer, in which R 'and R' ', identical or different, each represent a linear or branched C1-6 alkyl group, or R' and R '' together form a C2-3 alkylene chain, where the cycle thus formed being fused with a phenyl, and Xa represents a -SC (S) -OR group in which R represents a linear or branched C1-6 alkyl group, to give rise to the adduct of formula (4) in which R, R ', R' 'are as defined above, compound of formula (4) that can be optionally isolated, whose amine function can optionally be deprotected and converted into an acetamide function, which is subjected to a cyclization reaction in presence of a radical primer to form the compound of formula (5) I understood Note that the N ring group designates a protected amine defined in the group of formulas (6) in which R 'and R "are defined as above, compound of formula (5) whose amine function can optionally be deprotected, said compound of formula (5) is either subjected to a reduction / esterification followed by dehydration, or it is transformed into vinyl halide to give rise to the compound of formula (7) in which Y represents a halogen atom or a hydrogen atom, having the N ring group the same definition as above, compound of formula (7) whose protected amine function is converted to acetamide function where appropriate, that is, when this conversion has not taken place before, to give rise to the compound of formula (8 ) in which Y is as defined above, which is finally subjected to an aromatization reaction to give rise to the compound of formula (1) which is isolated in the form of a solid. |
| priorityDate | 2011-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.