| abstract |
This is related to compounds of the general formula (1), their tautomeric forms, stereoisomers, pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their elaboration, use of these compounds in medicine and the intermediates used in their elaboration. This is directed to compounds that can be used to treat diseases such as hyperlipidemia and also have a beneficial effect on cholesterol. Claim 1: Compounds of the formula (1) characterized by its tautomeric forms, stereoisomers, pharmaceutically acceptable salts and compositions pharmaceutically acceptable containing them where 'A' represents an optionally substituted simple or fused group selected from the aryl, heterocyclyl or cycloalkyl groups; 'Y' represents C1-6 alkyl, C2-6 alkenyl groups attached, substituted or unsubstituted, linear or branched, or groups represented by '-U (CH2) m-', where U represents O, S ( O) or, NR4; ‘M’ represents integers from 2 to 4, ‘or’ represents integers from 0 to 2 and R4 represents H, substituted or unsubstituted C1-6 alkyl, linear or with C1-6 alkyl branches; ‘Z’ represents a single or fused optionally substituted group of the aryl, heterocyclyl or cycloalkyl groups; ‘X’ represents a union or can be selected from O, S (O) or NR4 where R4 was defined above; ‘W’ represents C1-6 alkyl, C2-6 linear or branched alkenyl groups, substituted or unsubstituted; R1 represents hydrogen, optionally substituted C1-6 alkyl, C3-6 cycloalkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, aryl, heterocyclyl, aralkyl, heterocyclyl alkyl groups; R2 represents hydrogen, or groups selected from C1-6 alkyl, aryl, heterocyclyl, aralkyl, heterocyclylalkyl, C1-6 alkoxy, hydroxyalkyl, C1-6 alkylthio, amino, aminoalkyl, alkylamino, each of which may be optionally substituted ; or R1 and R2, when possible, together they can form 4 to 7 rings provided with saturated or partially saturated members containing 0-2 additional heteroatoms selected from the group of N, O and S (O) or; R3 in each occurrence independently represents hydrogen, halogen, C1-3 alkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 thioalkyl, sulfenyl derivatives, sulfonyl derivatives; ‘N’ represents integers from 0 - 3. |