http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-084531-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_84d9adaa7e7ce01ce8020f5c721aba10 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-64 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2863 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2818 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2803 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2809 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-468 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 |
| filingDate | 2011-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c1286a839df07458d683d26fe54e2a1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca7c02a2f243abb6fb83be99c907aa0b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e84f4392af65a89854681493fe110e07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32a8105843f35d765f7d8d79ff07ab2c |
| publicationDate | 2013-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-084531-A1 |
| titleOfInvention | MEDIUM-IMMUNOGLOBULIN UNION PROTEINS AND ITS USES |
| abstract | A pharmaceutical composition comprising the disclosed binding protein is also provided. Claim 1: A binding protein comprising a polypeptide chain, characterized in that the polypeptide chain comprises VD1- (X1) N-X2, wherein: VD1 comprises a heavy chain antigen binding domain; X1 comprises a domain selected from the group consisting of a polypeptide, a CH1 domain, a CH2 domain, a CH1 domain and a CH2 domain and a linker; N is 0 or 1; and X2 comprises a polypeptide comprising at least a portion of a CH3 domain, wherein the binding protein comprises at least one mutation in a residue to inhibit the dimerization of CH3-CH3, wherein the binding protein forms a binding site to the functional antigen. Claim 157: A binding protein conjugate, characterized in that it comprises a binding protein described in any one of claims 1 to 156, which further comprises an agent selected from the group consisting of; an immunoadhesion molecule, an imaging agent, a therapeutic agent and a cytotoxic agent. Claim 170: A nucleic acid characterized in that it encodes a polypeptide of any one of claims 1 to 165. Claim 173: Use of a binding protein of any one of claims 1 to 165, characterized in that it is for the preparation of a medicament for the treatment of a disease or condition selected from the group consisting of arthritis, osteoarthritis, juvenile chronic arthritis, septic arthritis, Lyme arthritis, psoriatic arthritis, reactive arthritis, spondyloarthropathy, systemic lupus erythematosus, Crohn's disease, ulcerative colitis, inflammatory bowel disease, insulin-dependent diabetes mellitus, thyroiditis, asthma, allergic diseases, psoriasis, dermatitis, scleroderma, graft versus host disease, organ transplant rejection, acute or chronic immune disease associated with organ transplantation, sarcoidosis, atherosclerosis, disseminated intravascular coagulation , disease of Kawasaki, Grave's disease, nephrotic syndrome, chronic fatigue syndrome, Wegener granulomatosis, Henoch-Schoenlein purpura, microscopic vasculitis of the kidneys, chronic active hepatitis, uveitis, septic shock, toxic shock syndrome, sepsis syndrome, cachexia , infectious diseases, parasitic diseases, acquired immunodeficiency syndrome, acute transverse myelitis, Huntington's chorea, Parkinson's disease, Alzheimer's disease, stroke, primary biliary cirrhosis, hemolytic anemia, malignant forms, heart failure, myocardial infarction, Addison, sporadic, polyglandular deficiency type I and polyglandular deficiency type II, Schmidt syndrome, adult respiratory distress syndrome (acute), alopecia, alopecia areata, seronegative arthropathy, arthropathy, Reiter's disease, psoriatic arthropathy, ulcerative colitis arthropathy, synovitis Enteropathic arthropathy associated with chlamydia a, yersinia and salmonella, spondyloarthropathy, atheromatous disease / atherosclerosis, atopic allergy, autoimmune bullous disease, pemphigus vulgaris, foliaceous pemphigus, pemphigoid, linear IgA disease, autoimmune hemolytic anemia, Coombs positive hemolytic anemia, acquired pernicious anemia, pernicious anemia, pernicious anemia Myalgic encephalitis / Royal Free disease, chronic mucocutaneous candidiasis, giant cell arteritis, primary sclerosing hepatitis, cryptogenic autoimmune hepatitis, acquired immunodeficiency disease syndrome, diseases related to acquired immunodeficiency, hepatitis B, hepatitis C, varied common immunodeficiency (hypo -g-common variable globulinemia), dilated cardiomyopathy, female sterility, ovarian insufficiency, premature ovarian insufficiency, fibrotic pulmonary disease, cryptogenic fibrosing alveolitis, postinflammatory interstitial lung disease, interstitial pneumonitis, diseased d interstitial lung associated with connective tissue diseases, lung disease associated with mixed connective tissue diseases, interstitial lung disease associated with systemic sclerosis, interstitial lung disease associated with rheumatoid arthritis, lung disease associated with systemic lupus erythematosus, lung disease associated with dermatomyositis / polymyositis, lung disease associated with Sjogren's disease, lung disease associated with ankylosing spondylitis, diffuse vasculitic lung disease, pulmonary disease associated with hemosiderosis, drug-induced interstitial lung disease, fibrosis, radiation fibrosis, obliterans bronchiolitis, chronic eosinophilic pneumonia, disease infiltrating lymphocytic lung, post-infectious interstitial lung disease, gouty arthritis, autoimmune hepatitis, autoimmune hepatitis type-1 (autoimmune hepatitis or classical lupoid hepatitis), autoimmune hepatitis type-2 (hepatitis by anti-LKM antibody), autoimmune hypoglycemia, insulin resistance type B with acanthosis nigricans, hypoparathyroidism, acute immune disease associated with organ transplantation, chronic immune disease associated with organ transplantation, osteoarthrosis, primary sclerosing cholangitis, psoriasis type 1, psoriasis type 2, idiopathic leukopenia, autoimmune neutropenia, renal disease NOS, glomerulonephritis, microscopic vasculitis of the kidneys, Lyme disease, discoid lupus erythematosus, idiopathic male sterility or NOS, autoimmune to sperm, multiple sclerosis (all subtypes) , sympathetic ophthalmia, pulmonary hypertension secondary to a connective tissue disease, Goodpasture syndrome, pulmonary manifestation of polyarteritis nodosa, acute rheumatic fever, rheumatoid spondylitis, Still's disease, systemic sclerosis, Sjogren's syndrome, Takayasu / arteritis disease, autoimmune thrombocytopenia tromboc idiopathic itopenia, autoimmune thyroid disease, hyperthyroidism, goitre autoimmune hypothyroidism (Hashimoto's disease), atrophic autoimmune hypothyroidism, primary myxedema, phacogenic uveitis, primary vasculitis, vitiligo, acute liver disease, chronic liver disease, alcoholic cirrhosis, alcohol-induced liver damage cholestasis, idiosyncratic liver disease, drug-induced hepatitis, nonalcoholic steatohepatitis, allergy and asthma, group B strep infection (GBS), mental disorders (e.g. depression and schizophrenia), diseases mediated by type Th2 and type Th1, acute pain and chronic (different forms of pain), and different types of cancer such as lung, breast, stomach, bladder, colon, pancreas, ovary, prostate and rectal cancer and hematopoietic malignant forms (leukemia and lymphoma), ab-lipoproteinemia, acrocyanosis , acute and chronic parasitic or infectious processes, acute leukemia, lin leukemia acute foblastic (ALL), acute myeloid leukemia (AML), acute or chronic bacterial infection, acute pancreatitis, acute renal failure, adenocarcinomas, aerial ectopic beats, AIDS dementia complex, alcohol-induced hepatitis, allergic conjunctivitis, allergic contact dermatitis , allergic rhinitis, allograft rejection, a-1-antitrypsin deficiency, amyotrophic lateral sclerosis, anemia, angina pectoris, anterior horn cell degeneration, anti cd3 therapy, antiphospholipid syndrome, anti-receptor hypersensitivity reactions, aortic and peripheral aneurysms , aortic dissection, arterial hypertension, arteriosclerosis, arteriovenous fistula, ataxia, atrial fibrillation (sustained or paroxysmal), atrial tachycardia, atrioventricular block, B-cell lymphoma, bone graft rejection, bone marrow transplant rejection (BMT), blockage His bundle branches, Burkitt lymphoma, heartburn, cardiac arrhythmias s, cardiac stunning syndrome, cardiac tumors, cardiomyopathy, inflammation response to a cardiopulmonary bypass, rejection of cartilage transplantation, degenerations of the cerebellar cortex, cerebellar disorders, chaotic or multifocal atrial tachycardia, disorders associated with a Chemotherapy, chronic myelocytic leukemia (CML), chronic alcoholism, chronic inflammatory pathologies, chronic lymphocytic leukemia (CLL), chronic obstructive pulmonary disease (COPD), chronic salicylate poisoning, colorectal carcinoma, congestive heart failure, conjunctivitis, contact dermatitis, cor lung disease, coronary artery disease, Creutzfeldt-Jakob disease, sepsis with negative culture, cystic fibrosis, disorders associated with cytokine therapy, pugilistic dementia, demyelinating diseases, dengue hemorrhagic fever, dermatitis, dermatological conditions, diabetes, diabetes mell itus, diabetic atherosclerotic disease, Lewy diffuse body disease, dilated congestive cardiomyopathy, basal ganglion disorders, Down syndrome in middle age, drug-induced movement disorders that block CNS dopamine receptors, drug sensitivity, eczema , encephalomyelitis, endocarditis, endocrinopathy, epiglottitis, Epstein-Barr virus infection, erythromelalgia, extrapyramidal and cerebellar disorders, familial hematophagocytic lymphohistiocytosis, rejection of the fetal thymus implant, Friedreich's ataxia, functional disorders of the peripheral arteries, fungal sepsis, fungal sepsis, fungal sepsis gas gangrene, gastric ulcer, glomerular nephritis, graft rejection of any organ or tissue, Gram-negative sepsis, Gram-positive sepsis, granulomas due to intracellular organisms, hair cell leukemia, Hallerrorden-Spatz disease, Hashimoto's thyroiditis, fever of hay, heart transplant rejection, hemac romatosis, hemodialysis, hemolytic uremic syndrome / thromb purpura |
| priorityDate | 2010-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.