http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-084349-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a9e9ce63eb0bbf3658453fb50a6d9b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4525 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-501 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 |
| filingDate | 2011-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_797b129acf455e88789e98c6135f77dc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64c252397804123d7b339fb173296d12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62f9e4510b1ed2effc3fb1275973fd96 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_228101d75caf3d1d347888e562589f0e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db4d22c8b0306f98e4205189a30428ce |
| publicationDate | 2013-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-084349-A1 |
| titleOfInvention | FUSIONATED DIHIDRO-PIRANO DERIVATIVES AS MODULATORS OF GPR119 |
| abstract | Pharmaceutical composition and uses Claim 1: Compound characterized by the formula (1) wherein R1 is selected from the group R1-G1 consisting of C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-3 alkyl, C3-6 alkenyl, C3-6 alkynyl, phenyl, C1-3 phenylalkyl and C1-3 heteroaryl alkyl, wherein each alkyl, alkenyl, alkynyl and cycloalkyl group may be optionally substituted with one or more RC substituents, and in the that in each cycloalkyl group a CH2 group can be optionally substituted by -NRN-, -O-, -S-, -SO-, -SO2-, -C (= O) -NRN-, -C (= O) - O- or SO2NRN-, and wherein each phenyl and heteroaryl ring may be optionally substituted with one or more LR substituents; and RN independently of one another is selected from the group RN-G1 consisting of H, C1-4 alkyl, C1-4-C (O) alkyl - and C1-4-S (= O) 2- alkyl; and Ar is selected from the group of Ar-G1 consisting of a 1,2,3,6-tetrahydro-pyridin-4-yl ring, a piperidin-4-yl ring, a piperazin-1-yl ring, a pyridin-2-onyl ring, a pyrazin-2-onyl ring, a pyridazin-3-onyl ring, a phenyl ring and a 5- or 6-membered heteroaromatic ring containing 1, 2 or 3 heteroatoms selected from N, O and S; and wherein optionally a second carbocyclic ring may be condensed with said first phenyl ring or heteroaromatic ring, wherein said second carbocyclic ring is unsaturated or aromatic and has 5 or 6 members, and may contain 1, 2 or 3 selected heteroatoms of N, O and S, and in which in said second carbocyclic ring 1 or 2 -CH2 groups can optionally be substituted by -N (RN) -, -C (= O) -, -S (= O) - or -S (= O) 2-, and wherein each of said pyridin-2-onyl ring, pyrazin-2-onyl ring, pyridazin-3-one ring, phenyl ring, heteroaromatic ring and / or the second carbocyclic ring independently of one another, may be optionally substituted with a T group and / or with one or more substituents selected from LAr; and wherein the N in said 1,2,3,6-tetrahydropyridin-4-yl, piperidin-4-yl and piperazin-1-yl ring may be substituted with C1-4-S alkyl (= O) 2 - or C3-6-S cycloalkyl (= O) 2-; and T is selected from the group T-G1 consisting of F, Cl, Br, I, CN, OH, NO2, C1-6 alkyl, C1-6 alkenyl, C1-6 alkynyl, C3-6 cycloalkyl, alkyl-O- C1-6, cycloalkyl-O- C3-6, alkyl-S-C1-6, HO-C (= O) -, C1-6-OC alkyl (= O) -, C1-4-C alkyl (= O ) -, C3-6-C cycloalkyl (= O) -, C1-4-S alkyl (= O) -, C1-4-S alkyl (= O) -C1-4 alkyl, C1-4-S alkyl ( = O) 2-, C1-4-S alkyl (= O) 2-C1-4 alkyl, RNT1RNT2N-, RNT1RNT2N-C1-3 alkyl, RNT1RNT2NC (= O) -, RNT1RNT2N-S (= O) 2-, RNT1RNT2N-C (= O) - (RN) N-, RNT1RNT2N-S (= O) 2-C1-4 alkyl, RNT1RNT2N-C (= O) -C 1-4 alkyl, heterocyclyl, heterocyclyl-O-, aryl and heteroaryl, in which each alkyl, alkenyl, alkynyl and cycloalkyl group may be optionally substituted with one or more substituents independently selected from each other of F, Cl, CN, OH, C1-3 alkyl, C3-6 cycloalkyl, alkyl-O- C1-3, aryl, heteroaryl and heterocyclyl, and in which aryl indicates phenyl or naphthyl, and wherein the heteroaryl is a 5- or 6-membered aromatic ring, containing 1, 2, 3 or 4 heteroatoms independently from each other, selected from N, O and S; and in which the heterocyclyl is an unsaturated or saturated carbocyclic ring, of 4 to 7 members, in which 1 or 2 groups -CH2- independently of each other, are replaced by NRN, O, -C (= O) -, S , -S (= O) - or -S (= O) 2-, and / or in which a group -CH- is replaced by N; and wherein each aryl, heteroaryl or heterocyclyl group may be optionally substituted with one or more substituents independently selected from LAr; and RNT1 is selected from the group RNT1-G1 consisting of H, C1-6 alkyl, C3-6 cycloalkyl, C1-6-C alkyl (= O) -, C1-6-S alkyl (= O) 2, heterocyclyl, aryl and heteroaryl, wherein each alkyl and cycloalkyl group may be substituted with one or more substituents independently selected from the group consisting of F, OH, CN, C1-4 alkyl, alkyl-O-C1-4, RN2N, C 1-4 alkyl (= O) 2-, C 3-6 alkyl, heterocyclyl, phenyl and heteroaryl; and wherein the heterocyclyl may be optionally substituted with one or more substituents independently selected from F, C1-4 alkyl, RN2N, OH and alkyl-O-C1-4; and wherein the heterocyclyl is a C4-7 cycloalkyl ring in which 1 or 2 -CH2 groups independently of each other are replaced by NRN, O, C (= O), S, S (= O) or S (= O) 2; and wherein the aryl is phenyl or naphthyl; and wherein the heteroaryl is a 5 or 6 membered aromatic ring, which contains 1, 2 or 3 heteroatoms independently from each other, selected from N, O and S; and wherein the aryl and heteroaryl may be optionally substituted with one or more LAr substituents; and RNT2 is selected from the group RNT2-G1 consisting of H and C1-6 alkyl; or RNT1 and RNT2 are joined to form a group selected from the RNT1RNT2-G1 group consisting of a C3-5 alkylene group, in which 1 or 2 -CH2- groups independently of each other are replaced by NRN, O, C (= O ), S, S (= O) or S (= O) 2; and which may be optionally substituted with one or more substituents independently selected from each other of F, C1-4 alkyl, (RN) 2N, OH and alkyl-O-C1-4; LR is selected from the group LR-G1 consisting of F, Cl, Br, CN, OH, NO2, C1-4 alkyl, C1-4 alkyl (= O) -, C1-4 alkyl-O-, (RN ) 2N- and C1-4-S alkyl (= O) 2-, in which each alkyl group may be optionally substituted with one or more F atoms, and in which each alkyl group may be optionally substituted with a selected substituent of OH, alkyl-O-C1-3 and CN; and LAr is selected from the group LAr-G1 consisting of F, Cl, Br, CN, OH, NO2, C1-4 alkyl, alkyl-O-C1-4, (RN) 2N-C (= O), (RN ) 2N- and C1-4-S alkyl (= O) 2-, in which each alkyl group may be optionally substituted with one or more substituents independently selected from each other of F, Cl, CN, OH and alkyl-O-C1 -3; and LP is selected from the group LP-G1 consisting of F and C1-3 alkyl, in which the alkyl group may be substituted with one or more F atoms; and LQ is selected from the group LQ-G1 consisting of H and C1-3 alkyl; and RC is selected from the group RC-G1 consisting of F, Cl, CN, OH, C1-4 alkyl, alkyl-O-C1-4, cycloalkyl-O-C3-7, cycloalkyl C3-7-alkyl C1-3 -O-, H2N-, (C1-4 alkyl) NH-, (C1-4 alkyl) 2N-, C1-4-C alkyl (= O) NH-, C1-4-S alkyl (= O) 2NH- , C1-4-C alkyl (= O) -, S-C1-4 alkyl, C1-4-S alkyl (= O) -, C1-4-S alkyl (= O) 2-, HO-C ( = O) -, C1-4-OC alkyl (= O) -, H2N-C (= O) -, (C1-4 alkyl) HN-C (= O) - and (C1-4 alkyl) 2N-C (= O) -, in which each alkyl or cycloalkyl group may be optionally substituted with one or more F atoms; and X1, X2, X3 are independently selected from the group X-G1 consisting of C (R2), and 0, 1 or 2 members of the group consisting of X1, X2, and X3 have the meaning of N; and R2 is selected from the group R2-G1 consisting of H, F, Cl, CN, OH, C1-4 alkyl, C3-7 cycloalkyl, F2HC, F3C, alkyl-O-C1-4, F2HC-O-, F3C -O- and cycloalkyl-O-C3-7; n is an integer selected from 0, 1, 2, 3 or 4; or a salt thereof. |
| priorityDate | 2010-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 53.