http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-084152-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 |
| filingDate | 2011-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb92e0fe4998399ee548e775c0ed5c5a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ecd12a5dadb3a9d32b5083ac9db254f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45590828fce09c7cdec31e2339d1a132 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94db340f489be26a21d28a776465b728 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1587176c842f346fcdb10c856e049df |
| publicationDate | 2013-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-084152-A1 |
| titleOfInvention | TRIAZOLOPIRIMIDINE COMPOUNDS AS INHIBITORS OF PDE10A, A PROCESS FOR THEIR OBTAINING, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE IN THE TREATMENT OF CNS DISEASES |
| abstract | These compounds inhibit PDE10A and can be used as medicaments for the treatment of mental and proliferative diseases. Claim 1: A compound of the formula (1) wherein: R1 is halogen, lower alkyl, lower haloalkyl, lower hydroxyalkyl, lower alkoxy, (lower alkoxy)-lower alkyl, -C (O) -NR9R10, aryl, heteroaryl or NR7R8, said aryl and heteroaryl may be substituted by 1-3 substituents independently selected from the group consisting of hydroxyl, halogen, lower alkyl, alkoxy lower, (lower alkoxy)-lower alkyl, lower haloalkyl and lower haloalkoxy; R2 is hydrogen, halogen, lower alkyl, lower haloalkyl, lower hydroxyalkyl, lower alkoxy or (lower alkoxy) -alkyl; R3 is hydrogen, lower alkyl, lower haloalkyl, lower hydroxyalkyl, lower alkoxy or (lower alkoxy)-lower alkyl; R4 is hydroxy, lower alkoxy or NR5R6; R5 and R6 are independently hydrogen, lower alkyl, lower haloalkyl, lower hydroxyalkyl, (lower alkoxy)-lower alkyl, cycloalkyl or heterocyclyl, or R5 and / or R6 are lower alkyl substituted by a substituent selected from the group consisting of heteroaryl, (lower alkyl) -heteroaryl and lower alkoxy-C (O) - or R5 and R6, together with the nitrogen atom to which they are attached, form a heterocyclyl, bicyclo-heterocyclyl or spiro-heterocyclyl, said heterocyclyl may be substituted by 1 - 3 substituents independently selected from the group consisting of hydroxyl, halogen, lower alkyl, lower alkoxy, (lower alkoxy) -alkyl, lower haloalkyl and oxo; R7 and R8 are independently hydrogen, lower alkyl, lower haloalkyl, lower hydroxyalkyl, (lower alkoxy)-lower alkyl or cycloalkyl or R7 and R8, together with the nitrogen atom to which they are attached, form a heterocyclyl optionally substituted by a substituent chosen from the group consisting of hydroxyl, halogen and oxo; and R9 and R10 are independently hydrogen, lower alkyl, lower haloalkyl, lower hydroxyalkyl or (lower alkoxy)-lower alkyl; or a pharmaceutically acceptable salt thereof. |
| priorityDate | 2010-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.