http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-084050-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a9e9ce63eb0bbf3658453fb50a6d9b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-351 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 |
| filingDate | 2011-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_797b129acf455e88789e98c6135f77dc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64c252397804123d7b339fb173296d12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_802d76dfde9f8c32f38d2352c00ee1eb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_228101d75caf3d1d347888e562589f0e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af2aee8a9c5db2b70d74b2b213350f60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_112dd83702ad0e8f953c3fb814a96a3b |
| publicationDate | 2013-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-084050-A1 |
| titleOfInvention | INDANILOXIDIHIDROBENZOFURANILACETIC ACIDS |
| abstract | They have valuable pharmacological activity. Particularly, the compounds are activators of the GPR40 receptor and, therefore, are suitable for the treatment and prevention of diseases that may be influenced by this receptor, such as metabolic diseases, in particular type 2 diabetes. Claim 1: A compound characterized because it has the formula (1), in which: R1 is selected from the group consisting of H, F, Cl, Br, I, C1-8 alkyl, C2-8 alkenyl, C2-6 alkynyl, C3- cycloalkyl 12, C3-12 cycloalkyl-C 1-4 alkyl, bicycloalkyl C5-12-, bicycloalkyl C5-12-alkyl C1-6-, cycloalkenyl C5-6, cycloalkenyl C5-6-alkyl C1-4, alkyloxyC 1-8, cycloalkyl C3-6-oxy and C3-6 cycloalkylC 1-4 alkyloxy, where any of these groups is optionally and independently substituted with 1 to 3 fluorine atoms and / or 1 to 3 R4 groups, C3-12 heterocyclyl, C3 heterocyclyl 12-C 1-4 alkyl, bicycloheterocyclyl, bicycloheterocyclyl-C 1-6 alkyl, heterocyclyl-C 1-4 alkyl, and C 3-12 heterocyclyloxy, d Where any of these groups is optionally and independently substituted with 1 to 3 R4 groups, aryl, arylC 1-4 alkyl, arylC 1-4 alkyl, oxyloxy, heteroaryl, heteroarylC 1-4 alkyl, heteroarylC1 alkyl -4-oxy and heteroaryloxy, where any of these groups is optionally and independently substituted with 1 to 5 R5 groups, C1-4 alkyl sulfanyl, C1-4 alkyl sulfinyl and C1-4 alkyl sulfonyl, where any of these groups it is optionally substituted with 1 to 3 fluorine atoms, and cyano, nitro, amino, C1-4 alkylamino and di- (C1-4 alkyl) -amino; where the heterocyclyl groups and sub-substances mentioned above may be partially unsaturated and comprise 1 to 3 heteroatoms or groups selected from N, NRN, O and S, with the proviso that only up to two of the heteroatoms are O and S, and not formed no OO, SS or SO bond, while a methylene group attached to a heteroatom can be replaced by a carbonyl group, while heterocyclyl groups are attached to the respective moiety through a carbon or nitrogen atom; RN represents H, C 1-4 alkyl, C 1-4 alkyl (O) - or C 1-4 alkyl (O) -, where the above-mentioned bicycloheterocyclyl groups and sub-substrates may be partially unsaturated and comprise from 6 to 12 ring members and 1 to 3 heteroatoms or groups selected from N, NRN, O and S, with the proviso that only up to two of the heteroatoms are O and S, and no OO, SS or SO link is formed, while that a methylene group attached to a heteroatom can be replaced by a carbonyl group, while heterocyclyl groups are attached to the respective moiety through a carbon or nitrogen atom; RN represents H, C 1-4 alkyl, C 1-4 alkyl (O) - or C 1-4 alkyl (O) -, where the above-mentioned bicycloalkyl and bicycloheterocyclyl groups and sub-substrates comprise fused, bridged and spiro ring systems, where the aforementioned aryl groups and sub-rests comprise from 6 to 10 carbon atoms, where, in the bicyclic aromatic groups, the ring that is not attached to the respective moiety may be partially saturated, and where the heteroaryl groups and sub-substances mentioned above consist of 5 to 14 atoms containing 1 to 3 heteroatoms selected from N, O or S (O) r, where r = 0, 1 or 2, where, in polycyclic heteroaromatic groups, rings that are not attached to the respective moiety can be partially or completely saturated, while at least one aromatic ring includes one or more heteroatoms; R 2 is selected from the group consisting of F, Cl, Br, I, cyano, C 1-4 alkyl, C 3-6 cycloalkyl and C 1-4 alkyloxy, where any alkyl or cycloalkyl group or sub-residue is optionally substituted with 1 to 3 atoms of fluorine; R3 is selected from the group consisting of F, Cl, Br, I, C1-4alkyl and C1-4alkyloxy, where any alkyl group or sub-substyl is optionally substituted with 1 to 3 fluorine atoms; R4 is selected from the group consisting of F, Cl, Br, I, cyano, C1-4 alkyl, hydroxy, hydroxy-C1-4 alkyl, C1-4 alkyl, oxy C1-4 alkyl C1-4 alkyl, C1-4 alkyl sulfanyl, C1-4 alkyl sulfinyl, C1-4 alkyl sulfonyl, C3-6- cycloalkyl, C3-6-oxycycloalkyl, wherein any alkyl or cycloalkyl group or sub-residue is optionally substituted with 1 to 3 fluorine atoms; and R5 is selected from the group consisting of F, Cl, Br, I, cyano, nitro, amino, C1-4-alkyl, di- (C1-4 alkyl) -amino, C1-4 alkyl, C2- alkenyl 4, C2-4 alkynyl, hydroxy, hydroxy-C1-4 alkyl, C1-4 alkyl-oxy, C1-4 alkyloxy-C1-4 alkyl, C1-4 alkyl sulfanyl, C1-4 alkyl sulfinyl, C1- alkyl 4-sulfonyl, C3-6- cycloalkyl, C3-6-oxy-cycloalkyl, wherein any alkyl or cycloalkyl group or sub-residue is optionally substituted with 1 to 5 fluorine atoms; m is selected between the numbers 0, 1, 2 and 3, preferably between the numbers 0, 1 and 2, or, more preferably, between the numbers 0 and 1, while the number 0 is the most preferred and n is selected from among the numbers 0, 1, 2 and 3, preferably between the numbers 0 and 1, while the number 0 is the most preferred, where in any definition mentioned hereinbefore and if nothing else is specified, any alkyl moiety mentioned in This request can be straight or branched chain, or a salt thereof. |
| priorityDate | 2010-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.