| abstract |
Improved topical gel compositions, such as those containing brimonidine, for the treatment of skin disorders. Claim 1: A gel composition for topical application, comprising the following: between 0.05 and 0.20% ( w / w) methylparaben; one or more second preservatives; between 0.80 and 1.50% (w / w) of a carbomer; between 9.0 and 13.0% (w / w) of total polyol, in which the gel composition for topical application has a pH between 4.5 and 7.5 and in which, when the methylparaben concentration is greater than 0.15% (w / w), carbomer concentration is less than 1.25% (w / w). Claim 3: The gel composition for topical application according to claim 1, wherein the gel composition further comprises an adrenergic receptor agonist a. |