http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-083398-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_84d9adaa7e7ce01ce8020f5c721aba10 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-582 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4184 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-422 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D453-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-695 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-438 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4164 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4355 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4418 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4184 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4523 |
| filingDate | 2011-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6f3f9ea8f314e87fea94122a427fc5af http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2feb722f007e186fe7f7612e6dc1504a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8eab1d5ed38f5b8f9d79e1231e2b3d89 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_beb5b84a0ca7cce0a9fdc4196c436597 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c285de875bd671882ca490dda8bc4df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0e5f09a0767333b86da0366144b38f9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57f38dc7e01af9ea107b225ed4dee799 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1bba23b8321c018bb73f155cb48fb14c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6784435e1ff5a47dad7e046196c6f69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_703495244142a5b79b28e0eedc997eee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_695b634f93ed1f75551064a60156a7e7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4090d92f99bc07afe71e92ab73017cd6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a39d9fc2baf66e8184652225b6e89247 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3355ca7d6d6d503086db2efe2c1dc609 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_742754625dca060da3a5cc0413861372 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5e94a062660ebbe2eda9ef13e6f878b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35bf39e281872bd6a04e4e9193dc4c53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0cb91b2106396e34d415ba53236c1e83 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7c1d49f3e5e5c917479c5c36ab12fc4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e395b3565fbefa04046316a42ab889b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32a8105843f35d765f7d8d79ff07ab2c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3cbbeb09aab1bd8e0d1e82158f957eb0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0ec5329475d5d231ff45047220b9f92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21d482fa026a99c87af7f4de6e77672c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0901607816ab275449fb17a066cf178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bec78fa3225d3f250246b2fd52ef8af0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ae9453c01714feff02eae80c7956647 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_776c042b27c6111ebcb35cd3be6bf0c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab5ef7cc4cc986bb760411625c32753c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_336227aade570d007b353121cbb89d7c |
| publicationDate | 2013-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-083398-A1 |
| titleOfInvention | ANTIVIRAL COMPOUNDS |
| abstract | Effective compounds to inhibit the replication of the hepatitis C virus ("HCV"); manufacturing processes of such compounds, compositions comprising them and methods of using them to treat an HCV infection. Claim 1: A compound characterized in that it is of formula (1), or a pharmaceutically acceptable salt thereof, wherein: X it is C3-12 carbocycle or 3 to 12 member heterocycle, and is optionally substituted with one or more RA or RF; L1 and L2 are independently selected from each other among a link; or C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene, each of which is optionally independently substituted in each case with one or more RL; L3 is a link or -LS-K-LS'-, where K is selected from a link, -O-, -S-, -N (RB) -, -C (O) -, -S (O) 2 -, -S (O) -, -OS (O) -, -OS (O) 2-, -S (O) 2O-, -S (O) O-, -C (O) O-, -OC (O) -, -OC (O) O-, -C (O) N (RB) -, -N (RB) C (O) -, -N (RB) C (O) O-, -OC ( O) N (RB) -, -N (RB) S (O) -, -N (RB) S (O) 2-, -S (O) N (RB) -, -S (O) 2N (RB ) -, -C (O) N (RB) C (O) -, -N (RB) C (O) N (RB ') -, -N (RB) SO2N (RB') -, or -N ( RB) S (O) N (RB ') -; A and B are independently C3-12 carbocycle or 3 to 12 member heterocycle, and are optionally independently substituted with one or more RA; D is C3-12 carbocycle or 3-12 membered heterocycle, and is optionally substituted with one or more RA; or D is C3-12 carbocycle or 3- and 12-membered heterocycle that is substituted with J and optionally substituted with one or more RA, where J is C3-12 carbocycle or 3- and 12-membered heterocycle and is optionally substituted with one or more RA, or J is -SF5; or D is hydrogen or RA; Y is selected from -T'-C (R1R2) N (R5) -T-RD, -T'-C (R3R4) C (R6R7) -T-RD, -LK-T-RD, or -LK-E ; R1 and R2 are independently of each other RC, and R5 is RB; or R1 is RC, and R2 and R5, taken together with the atoms to which they are attached, form a 3- to 12-membered heterocycle that is optionally substituted with one or more RA; R3, R4, R6, and R7 are independently of each other RC; or R3 and R6 are independently from each other RC, and R4 and R7, taken together with the atoms to which they are attached, form a carbocycle or heterocycle of between 3 and 12 members that is optionally substituted with one or more RA; Z is selected from -T’-C (R8R9) N (R12) -T-RD, -T’-C (R10R11) C (R13R14) -T-RD, -LK-T-RD or -LK-E; R8 and R9 are independently of each other RC, and R12 is RB; or R8 is RC, and R9 and R12, taken together with the atoms to which they are attached, form a 3 to 12 member heterocycle that is optionally substituted with one or more RA; R10, R11, R13, and R14 are independently of each other RC; or R10 and R13 are independently from each other RC, and R11 and R14, taken together with the atoms to which they are attached, form a carbocycle or heterocycle of between 3 and 12 members that is optionally substituted with one or more RA; T and T 'are independently selected from each other in each case between a link, -LS-, -LS-M-LS'-, or -LS-M-LS'-M'-LS' '-, where M and M 'are independently selected from each other in each case between a link, -O-, -S-, -N (RB) -, -C (O) -, -S (O) 2-, -S ( O) -, -OS (O) -, -OS (O) 2-, -S (O) 2O-, -S (O) O-, -C (O) O-, -OC (O) -, -OC (O) O-, -C (O) N (RB) -, -N (RB) C (O) -, -N (RB) C (O) O-, -OC (O) N (RB ) -, -N (RB) S (O) -, -N (RB) S (O) 2-, -S (O) N (RB) -, -S (O) 2N (RB) -, -C (O) N (RB) C (O) -, -N (RB) C (O) N (RB ') -, -N (RB) SO2N (RB') -, -N (RB) S (O) N (RB ') -, C3-12 carbocycle or 3 to 12 member heterocycle, and wherein said C3-12 carbocycle and 3 to 12 member heterocycle are optionally substituted independently of each other in each case with one or more RA; LK is independently selected in each case from a link, -LS-N (R8) C (O) -LS’- or -LS-C (O) N (RB) -LS’-; or C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene, each of which is optionally independently substituted in each case with one or more RL; or C3-12 carbocycle or 3 to 12 member heterocycle, each of which is optionally independently substituted in each case with one or more RA; E is independently selected in each case from C3-12 carbocycle or 3-12 membered heterocycle, and is optionally independently substituted in each case with one or more RA; RD is independently selected in each case from hydrogen or RA; RA is independently selected in each case from halogen, nitro, oxo, phosphonoxy, phosphono, thioxo, cyano, or -LS-RE, where two adjacent RAs, taken together with the atoms to which they are attached and any other atom between Atoms to which they are attached may optionally form carbocycle or heterocycle; RB and RB ’are independently selected from each other in each case between hydrogen; or C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl, each of which is optionally independently substituted in each case with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo , phosphonoxy, phosphono, thioxo, formyl, cyano or carbocycle or heterocycle of 3 to 6 members; or carbocycle or heterocycle of 3 to 6 members; where each carbocycle or heterocycle of between 3 and 6 members in RB or RB 'is optionally independently substituted in each case with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 2-6 haloalkenyl or C 2-6 haloalkynyl; RC is independently selected in each case from hydrogen, halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl or cyano; or C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl, each of which is optionally independently substituted in each case with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo , phosphonoxy, phosphono, thioxo, formyl, cyano or carbocycle or heterocycle of 3 to 6 members; or carbocycle or heterocycle of 3 to 6 members; where each carboxy or heterocycle of between 3 and 6 members in RC is optionally independently substituted in each case with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl , cyano, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 2-6 haloalkenyl or C 2-6 haloalkynyl; RE is independently selected in each case from -O-RS, -S-RS, -C (O) RS, -OC (O) RS, C (O) ORS, N (RSRS '), S (O) RS, SO2RS, -C (O) N (RSRS '), N (RS) C (O) RS' -N (RS) C (O) N (RS'RS ''), N (RS) SO2RS ', -SO2N (RSRS '), -N (RS) SO2N (RS'RS' '), -N (RS) S (O) N (RS'RS' '), -OS (O) -RS, -OS ( O) 2-RS, -S (O) 2ORS, -S (O) ORS, -OC (O) ORS, -N (RS) C (O) ORS ', -OC (O) N (RSRS'), N (RS) S (O) RS ', -S (O) N (RSRS'), -P (O) (ORS) 2, or -C (O) N (RS) C (O) -RS '; or C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl, each of which is optionally independently substituted in each case with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo , phosphonoxy, phosphono, thioxo, formyl or cyano; or C3-6 carbocycle or 3-6 membered heterocycle, each of which is optionally independently substituted in each case with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy , phosphono, thioxo, formyl, cyano, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C2-6 haloalkenyl, C2-6 haloalkynyl, C (O) ORS, or N (RSRS ' ); RF is independently selected in each case from C1-10 alkyl, C2-10 alkenyl or C2-10 alkynyl, each of which contains 0, 1, 2, 3, 4 or 5 heteroatoms selected from O, S or N and is optionally substituted with one or more RL; or - (RX-RY) Q- (RX-RY '), where Q is 0, 1, 2, 3 or 4, and each RX is independently O, S or N (RB), where each RY is in independently C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene each of which is optionally independently substituted with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl or cyano, and where each RY 'is independently C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl each of which is optionally independently substituted with one or more substituents selected from halogen , hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl or cyano; RL is independently selected in each case from halogen, nitro, oxo, phosphonoxy, phosphono, thioxo, cyano, -O-RS, -S-RS, -C (O) RS, -OC (O) RS, -C (O) ORS, -N (RSRS '), -S (O) RS, -SO2RS, -C (O) N (RSRS') or -N (RS) C (O) RS '; or C3-6 carbocycle or 3-6 membered heterocycle, each of which is optionally independently substituted in each case with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy , phosphono, thioxo, formyl, cyano, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 2-6 haloalkenyl or C 2-6 haloalkynyl; where two adjacent RLs, taken together with the atoms to which they are attached and any other atom between the atoms to which they are attached, can optionally form carbocycle or heterocycle; LS, LS "and LS" are independently selected from each other in each case between a link; or C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene, each of which is optionally independently substituted in each case with one or more RL; and RS, RS ’and RS’ ’are independently selected |
| priorityDate | 2010-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 78.