| abstract |
A cyclopropane compound represented by formula (1) or a pharmaceutically acceptable salt thereof has orexin receptor antagonism and, therefore, has a useful potential for the treatment of sleep disorder for which orexin receptor antagonism is effective. Claim 1: A compound represented by the formula (1) or a pharmaceutically acceptable salt thereof characterized in that Q represents -CH- or a nitrogen atom, when Q represents -CH-, R1a and R1b each represent, of independently, a C1-6 alkyl, halo- C1-6 alkyl or a C1-6 alkoxy-C1-6 alkyl group, R1c represents a hydrogen atom, R2a, R2b, R2c and R2d each independently represent, a hydrogen atom, a halogen atom, a C1-6 alkyl group, C1-6 alkoxy or halo- C1-6 alkyl, R3a and R3c each independently represent a hydrogen atom, halogen, an alkyl group C1-6, halo- C1-6 alkyl, C1-6 alkoxy, alkoxy C1-6-C1-6 alkyl, cyano or cyano-C1-6 alkyl, R3b represents a hydrogen atom, halogen, a C1-6 alkyl group, halo- C1-6 alkyl, C1-6 alkoxy or C1-6 alkoxy -C1-6 alkyl, and R3d represents a hydrogen atom or a fluorine atom, or when Q represents a nitrogen atom, R1a and R1b each independently represent a C1-6 alkyl, halo-C1 alkyl group -6, hydroxy-C1-6 alkyl or a C1-6 alkoxy-C1-6 alkyl group, R1c represents a hydrogen atom or a hydroxyl group, R2a, R2b, R2c and R2d each independently represent an atom of hydrogen, halogen, a hydroxyl group, C1-6 alkyl, C1-6 alkoxy or halo- C1-6 alkyl, R3a represents a hydrogen atom, halogen, a C1-6 alkyl group, C1-6 alkoxy or an alkoxy group C1-6-C1-6 alkyl, R3b represents a hydrogen atom, halogen, a C1-6 alkyl or halo-C1-6 alkyl group, R3c represents a hydrogen atom, halogen, a C1-6 alkyl group, halo- C1-6 alkyl, C1-6 alkoxy, at C1-6 coxy-C1-6 alkyl or a cyano group, and R3d represents a hydrogen atom. |