| abstract |
This refers to Multifunctional Antibody Conjugates, which comprise an antibody or antigen binding portion thereof, comprising at least a fragment of a light chain constant region (CLk), which comprises K188 according to Kabat numbering. ; a linker comprising the formulas XYZ, wherein Z is a group that is covalently connected to the antibody through the side chain of K188, Y is a linear or branched biologically compatible connection chain, and X is a group covalently connected to at least one effector rest. Specific MAC compounds and compositions are also provided. |