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publicationDate 2012-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber AR-081875-A1
titleOfInvention USE OF THE ASSOCIATION OF A SINUSAL CURRENT INHIBITOR I AND AN INHIBITOR OF THE ANGIOTENSIN CONVERSION ENZYME FOR THE TREATMENT OF CARDIAC INSUFFICIENCY
abstract Use of the association of a selective and specific inhibitor of the sinus current If, more particularly ivabradine or N - {[(7S) -3,4-dimethoxybicyclo [4.2.0] octa-1,3,5-trien- 7-yl] methyl} -3- (7,8-dimethoxy-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl) -N-methyl-3-oxo-1-propanamine and of an angiotensin-converting enzyme inhibitor for the purpose of obtaining medicaments for the treatment of heart failure, more particularly of heart failure with preserved systolic function. Claim 10: Pharmaceutical compositions containing as active ingredients: ivabradine, in hydrochloride form or one of its hydrates or crystalline forms; and perindopril, in the form of tert-butylamine or arginine salt or one of its crystalline hydrates or forms, alone or in combination with one or more pharmaceutically acceptable excipients, for use in the treatment of heart failure. Claim 12: Pharmaceutical compositions containing as active ingredients: N - {[(7S) -3,4-dimethoxycycle [4.2.0] octa-1,3,5-trien-7-yl] methyl} -3- ( 7,8-dimethoxy-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl) -N-methyl-3-oxo-1-propanamine, in the form of hydrochloride or fumarate or of one of its hydrates or crystalline forms; and perindopril, in the form of tert-butylamine or arginine salt or one of its crystalline hydrates or forms, alone or in combination with one or more pharmaceutically acceptable excipients.
priorityDate 2010-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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