http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-081630-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_55bc16a72c2c5b27d73ac60ad6e60706 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_08ac2bffb06de3c30be9b61efaeb5f86 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-805 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-49 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate | 2011-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2012-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-081630-A1 |
| titleOfInvention | METHOD FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION CONTAINING A THERMOSTABLE OXYGEN CONVEYOR |
| abstract | There is a highly purified and thermostable cross-linked non-polymeric tetrameric hemoglobin suitable for use in mammals without causing renal injury or vasoconstriction. A high temperature and short time thermal processing step (HTST) is carried out to eliminate the harmful dimeric form of hemoglobin, uncrossed tetrameric hemoglobin and plasma protein impurities effectively. The addition of N-acetyl cysteine after heat treatment and, optionally, before heat treatment maintains a low level of methemoglobin. Thermostable crosslinked tetrameric hemoglobin can improve and prolong oxygenation in normal and hypoxic tissue. In another aspect, the product is used in the treatment of various types of cancer such as leukemia, colorectal cancer, lung cancer, breast cancer, liver cancer, nasopharyngeal carcinoma and esophageal cancer. Another application is the preservation of the heart in situations where there is a lack of oxygen supply in vivo, such as in heart transplantation or the heart deprived of oxygen. |
| priorityDate | 2010-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 24.