| abstract |
More specifically, the compounds herein are H3 receptor modulators and, therefore, are useful as pharmaceutical agents, especially in the treatment and / or prevention of a variety of diseases modulated by H3 receptors, including diseases associated with the Central Nervous System. Additionally, the present invention also discloses methods of preparing N-alkyl- and N-acyltetrahydroisoquinolines derivatives of formula (1) and intermediates thereof. Claim 1: A compound of formula (1): wherein n it is 0 or 1; m is 1 or 2; p is 1 or 2; X is O or HH; R is CH3, ethyl or propyl; R 1 is H, CH 3 or OCH 3 and R 2 is C 1-4 alkyl, cyclohexyl, C 5-8 cycloalkylcarbonyl, benzyl, benzoyl, phenylsulfonyl, furancarbonyl, tetrahydropyranyl, C 1-4 alkoxycarbonyl, phenoxycarbonyl, C 1-4 alkylcarbonyl, substituted or unsubstituted phenylaminocarbonyl, wherein the substituents are selected from the group consisting of halogen, C1-4 alkyl, C1-4 alkoxy and C1-4-CO- alkoxy; or a salt thereof or enantiomer or diastereomer thereof. |