http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-080327-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a9e9ce63eb0bbf3658453fb50a6d9b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 |
| filingDate | 2011-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89d91aae68b95084e4eada863c8840f9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2208c3960da42c400f5ecf15f5cff747 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7cfa317c51721aa8ceea8e26edf6ec09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c92b7f6e9f50c24b55ecf716e6dc51ee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1adea057b66f9c6d1c88c1b25cc770ef http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3f813d4f679d9b76bfbee77218a1367 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed102277bafeaf91449811c91f87633e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a15b04e219aaf9a9f1af0d16b6ad8c89 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_522aeb3d7c71896ea790ad717eefc094 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bfee82999d07236647b2bfbf5163bfa8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ca33384a59280c589b057adbe6c2e0f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_732e841493fbeb79b39a487564ce633b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4ba7473ad17155a0faa592d2075a0e9 |
| publicationDate | 2012-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-080327-A1 |
| titleOfInvention | TIENOPIRIMIDINES CONTAINING HYKITROCYLKYL INHIBITORS OF MNK1 AND / OR MNK2 KINASES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE OF THE SAME FOR THE TREATMENT OF METABOLIC DISORDERS SUCH AS DIABETES AND OBESTRESSES. |
| abstract | Claim 1: A compound characterized in that it has the general formula (1) in which X is CH or N, R1 is H, halogen, CN, CH3 or CF3, R2 is a group selected from (2) where the group can be substituted in the nitrogen atom with (3) -SO2- (C1-3 alkyl), -CO- (C1-3 alkyl), -CO- (CH2) nO- (C1-3 alkyl), -CO- (CH2) nN (C1-3 alkyl) 2, C1-4 alkyl, - (CH2) n-CF3, - (CH2) n-CHF2, - (CH2) n-OH, - (CH2) nO- (C1-3 alkyl) , - (CH2) n-CN, (4) and where it can be substituted on a carbon atom with a group -CH2OH, where n is 1 or 2, and where the group can be substituted on the nitrogen atom with alkyl ( 3) C1-4 linear or branched, - (CH2) n-CF3, - (CH2) n-CHF2, - (CH2) n-OH, - (CH2) nO- (C1-3 alkyl), - (CH2) n-CN, - (CH2) n-CO-N (C1-3 alkyl) 2, -SO2- (C1-3 alkyl), -CO- (C1-3 alkyl), -CO2 (C1-4 alkyl), -CO2- (CH2) n-CF3, -CO2- (CH2) nO- (C1-3 alkyl), -CO2- (CH2) n-CO-N (C1-3 alkyl) 2, (4) where n is 1 or 2, R3 a C1-2 alkyl group, and R4 is -COOH, -CO2 (C1-3 alkyl), -CO2- (CH2) nN (C1-3 alkyl) 2, -CONH2, -CO-NHR5, -CO-NH- (CH2) p-R6, -CO-NH- (CH2) m-R7, -CO-N (CH3) - (CH2) m-R7, CO-N (CH3) - (CH2) -cyclohexyl, (5), R5 is -CN, -OH, linear or branched C1-6 alkyl, -O (C1-3 alkyl), C3-6 cycloalkyl, -SO2- (C1 alkyl -3); pyrazolyl optionally substituted with methyl; or piperidinyl optionally substituted with methyl, where the C3-6 cycloalkyl group may be substituted with -NH2, -OH or -OCH3; R6 is -C (CH3) 2Cl; -C (CH3) 2OH; -CHC3-6 cycloalkyl, which is optionally substituted with OH; imidazolyl, which is optionally substituted with methyl; pyrrolidinyl, which is optionally substituted with C1-3alkyl or with an oxo group; tetrahydrofuranyl; tetrahydropyranyl; phenyl, which is optionally substituted with one or two -F, -CI, -CN, -OH, C1-3 alkyl or -O (C1-3 alkyl); naphthyl; pyridinyl; furanyl; thiophenyl; oxazolyl; thiazolyl; pyrazolyl; morpholinyl, which is optionally substituted with methyl; benzothiophenyl; -CO-phenyl; or -SO2-N (C1-3 alkyl) 2, and R7 is F, -OH, -OCF3, -O- (C1-3 alkyl), -O-phenyl, -O (CH2) m-OH, -N (C1-3 alkyl) 2, -NH-phenyl, piperidinyl, pyrrolidinyl, azetedinyl or aziridinyl, and where the hydrogen atom in the NH groups can be replaced with C1-3 alkyl, where p is 1, 2 or 3, and m is 2 or 3, or a tautomer, enantiomer, diastereomer or salt thereof. |
| priorityDate | 2010-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 63.