http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-080074-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a9e9ce63eb0bbf3658453fb50a6d9b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 |
| filingDate | 2011-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff9d614067e2b34a0a0ac0ebf55a78a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4d2844bff2892b1b6a7869876dab93a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f458da84b872a1006044c668c0049f3b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_561bc8311e393d1ec52bdbd95df9255e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1acd4bf37965a3ab3787662719d36a07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_70fb1641c7bb7516dfd2e137e95cb07d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b8ba1de4d9d8654a449fe895d6ec4a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0beb798988c91814800a1d3220021b0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f389eeaf8666e8e6f74c6b935639d74a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b67a8ce16dbd63a418e3475ed4ee7578 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b87ab051a2d451299cedd63a826dcf6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d73a029308671f8b5203bfd667820df |
| publicationDate | 2012-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-080074-A1 |
| titleOfInvention | REPLACED NAFTIRIDINS AND THEIR USE AS MEDICATIONS |
| abstract | Pharmaceutical compositions containing these compounds, and uses thereof. Claim 1: A compound characterized in that it has the formula (1) in which R1 is selected from -O-R3 or -NR3R4 where R3 is C1-6 alkyl substituted with R5 and R6 where R5 is selected from hydrogen, C1-6 alkyl linear or branched, C2-6 alkenyl, -C 1-6 alkyl-O-C 1-3 alkyl, C 1-3 haloalkyl, where R 6 is an X ring of formula (2); where n is 0 or 1, where it is either a single bond or a double bond and where A, B, D and E are each independently selected from CH2, CH, C, N, NH, O or S and where the ring X is attached to the molecule by position A, B, D or E, where said ring X may be optionally substituted with one, two or three residues each individually selected from the group consisting of -oxo, hydroxy, -C1 alkyl -3, C1-3 haloalkyl, C1-3 alkyl, C1-3 alkanol and halogen, R4 is selected from the group consisting of hydrogen and C1-6 alkyl, R2 is selected from the group consisting of hydrogen; aryl of 5 to 10 members; 5 to 10 member heteroaryl comprising 1, 2 or 3 heteroatoms each individually selected from N, O and S; 5 or 10-membered saturated or partially unsaturated heterocycle comprising 1, 2 or 3 heteroatoms each individually selected from N, O and S; saturated or partially unsaturated cycloalkyl of 3 to 10 members, where - in case R2 is not hydrogen - said R2 may be optionally substituted with 1, 2, 3 or 4 residues, each individually selected from the group consisting of hydrogen, -oxo, halogen, -C1-6 alkyl, -C2-6 alkenyl, -C1-6 alkylene-COOH, -COOH, -CO-NR9R10, -C1-6 alkylene-CO-NR9R10, -C1-6-NR9R10 alkylene , -C1-6-CO-Q, -CO-Q, -C1-6-CO-NR9Q, -CO-NR9Q, -C1-6-NR11-CO-NR9R10, -C1-6-NR11 -CO-Q, -C1-6-NR11-SO2R9, -C1-6-O-CO-R9, -C1-6-O-CO-NR9R10, -C1-6-O-R9-alkylene, - C1-6-SO-NR9R10, -C1-6-SO2R9, -C1-6-SOR9, -C1-6-O-R9, -C1-6-Q-alkylene, -C1 -6-NR9R10-alkylene , C5-10 aryl, -Q, -C3-8 cycloalkyl, -O-R7, -O-C1-6-R7 alkylene, -O-C1-6 alkylene-O-R7, -C1-3 haloalkyl, cyanide, -NR11R7, -NR11 (C1-6-R7 alkylene), -S (O) -C1-6 alkyl, -SO2-C1-6 alkyl, -S-C1-6 alkyl, -SO2-NR9R10, -SO2-NR11Q heteroaryl 5 to 10 members comprising 1, 2 or 3 heteroatoms each individually selected from N, O and S, -NR11-CO-R7 and -O-CO-R7, where R7 is selected from the group consisting of hydrogen; C1-6 linear or branched alkyl; C1-6 haloalkyl; -C1-6-COOH alkylene; -alkyl C1-6-CO-NR9R10; -C1-6-CO-Q alkylene; -alkyl C2-6-NR11-CO-NR9R10; -alkyl C2-6-NR11-CO-Q; -alkyl C2-6-NR11-SO2R9; -alkyl C2-6-NR9R10; -C2-6-Q alkylene; -C2-6-O-CO-R9, -C2-6-O-CO-NR9R10, -C2-6-SO-NR9R10, -C2-6-SO2-R9, -C2-6- SO-R9, -SO2-R9, -SO-R9, -SO2-NR9R10, -SO2-NR11Q, -SO2-Q, -alkylene C1-6-O-R9 -CO-NR9R10, -CONR9Q, -CO-R9 , -CO-Q, -C1-6-Q alkylene, -C5-10 aryl, -Q, saturated or partially unsaturated cycloalkyl of 3 to 8 members; 5 to 10 member heteroaryl comprising 1, 2 or 3 heteroatoms each individually selected from N, O and S; -C1-6-heteroaryl alkyl, wherein this heteroaryl has 5 to 10 members and comprises 1, 2 or 3 heteroatoms each individually selected from N, O and S; where - in case R7 is not hydrogen - R7 can be optionally substituted with 1, 2 or 3 R8 residues that are individually selected from the group consisting of hydrogen; -oxo; hydroxy; -C 1-6 alkyl; C1-6 haloalkyl; -NR9R10, -Q, -NR9Q, saturated or partially unsaturated cycloalkyl of 3 to 6 members; where - in case R8 is not hydrogen - R8 may optionally be substituted with 1, 2 or 3 residues selected from hydrogen, -oxo, -hydroxy, -C1-6 alkyl, halogen, -haloalkyl C1-6, -O- C1-6 alkyl, -C 1-3 alkyl-O-C1-3 alkyl, where each of R9, R1 ° and R11 is individually selected from each other from the group consisting of hydrogen, -C1-6 alkyl, -C3 cycloalkyl -8, -C 1-6 alkyl-C 3-8 cycloalkyl and phenyl, and where each Q is individually selected from either a saturated or partially unsaturated heterocycle of 5 to 10 members or a partially unsaturated heterocycle comprising 1, 2 or 3 heteroatoms each individually selected from N, O or S, or from a 5- to 10-membered heteroaryl comprising 1, 2 or 3 heteroatoms each individually selected from N, O and S; where Q is attached to the rest of the molecule either by a carbon atom or by a nitrogen atom, the N-oxides of the aforementioned compounds, particularly the 1-naphthyridinyl oxides of the aforementioned compounds, and the pharmaceutically salts Acceptable of the aforementioned compounds. |
| priorityDate | 2010-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 66.