http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-079725-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fdb2b95ca7f4d374a06f2273bb1677b1 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-48 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-16 |
| filingDate | 2010-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c359b9e32ff0f9a23253fd436c4be10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb7e70f73e471c8fa07b2bc6c4606ad8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f05c156d0550712beea51299b90af332 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0ed551d7487e1c923b1ceae0afec541 |
| publicationDate | 2012-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-079725-A1 |
| titleOfInvention | DERIVATIVES OF AMINOALQUILPIRIMIDINA AS ANTAGONISTS OF THE H4 RECEIVER |
| abstract | These compounds are useful as histamine H4 receptor antagonists. Pharmaceutical compositions, preparation procedure and uses. Claim 1: A compound characterized by the formula (1) wherein R1 and R2 form, together with the N atom to which they are attached, a saturated heterocyclic group selected from (i) a heterocyclic group containing 2 N atoms and does not contain no other heteroatom, wherein said heterocyclic group is optionally substituted with one or more C1-4 alkyl groups; and (ii) a heterocyclic group containing 1 N atom and not containing any other heteroatom, wherein said heterocyclic group is substituted with a -NRaRb group and is optionally substituted with one or more C1-4 alkyl groups; wherein said heterocyclic groups (i) and (ii) are monocyclics of 4 to 7 members, bicyclics with bridges of 7 to 8 members or condensed bicyclics of 8 to 12 members; or R1 represents H or C1-4 alkyl, and R2 represents azetidinyl, pyrrolidinyl, piperidinyl or azepanyl, which are optionally substituted with one or more C1-4 alkyl groups; Ra represents H or C1-4 alkyl; Rb represents H or C1-4 alkyl; or Ra and Rb together with the N atom to which they are attached, an azetidinyl, pyrrolidinyl, piperidinyl or azepanyl group optionally substituted with one or more C1-4 alkyl groups; R3 represents H or C1-8 alkyl; R4 represents C1-8 alkyl optionally substituted with one or more halogens, C3-10 cycloalkyl-C0-4 alkyl, heterocycloalkyl-C0-4-alkyl, aryl-C0-4-alkyl or heteroaryl-C0-4-alkyl, where in the C3-10 cycloalkyl-C0-4 alkyl, heterocycloalkyl-C0-4-alkyl, aryl-C0-4-alkyl and heteroaryl-C0-4-alkyl groups any alkyl group is optionally substituted with one or more R6 groups, any of the cycloalkyl and heterocycloalkyl groups are optionally substituted with one or more substituents independently selected from C1-8 alkyl and halogen, and any of the aryl and heteroaryl groups are optionally substituted with one or more R7 groups; each R5 independently represents H or C1-8 alkyl; each R6 independently represents C1-8 alkyl, halogen, hydroxy-C0-6-alkyl, C3-10 cycloalkyl optionally substituted with one or more C1-8 alkyl groups, or phenyl optionally substituted with one or more R8 groups, and optionally two groups R6 on the same carbon atom are attached forming a C2-5 alkylene group that is optionally substituted with one or more C1-8 alkyl groups; each R7 independently represents C1-8 alkyl, halo-C1-6-alkyl, halogen, C1-6 alkoxy, halo-C1-6-alkoxy, -CN, C1-6 alkylthio, C2-4 alkynyl, hydroxy-C0-6 -alkyl, CO2R9-C0-6 alkyl, -CONR9R9, -SO2NR9R9, -S02-C1-6 alkyl, -NR9SO2-C1-6 alkyl, -NR9CONR9R9, -NR9COR9, -NR9R9, C3-10 cycloalkyl, aryl or alkyl heteroaryl; wherein any of the C3-10 cycloalkyl, heterocycloalkyl, aryl or heteroaryl groups in R7 is optionally substituted with one or more C1-8 alkyl groups; each R8 independently represents C1-8 alkyl, halo-C1-6-alkyl, halogen, C1-6 alkoxy, halo-C1-6-alkoxy or -CN; each R9 independently represents H or C1-8 alkyl; and optionally two A9 groups are linked to form a C3-5 alkylene group which is optionally substituted with one or more C1-8 alkyl groups; and n represents 1 or 2; or a salt thereof. |
| priorityDate | 2009-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID456171974 http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID457444288 |
Total number of triples: 48.