http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-079135-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_132aa5ddba376cda52c2bedb26765245 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| filingDate | 2010-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1a92ed1e512a50161c31a523b90d5dd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4455ffa8625d97b2448f6eb005325d53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8c0d2348261eb7875021b555b923a7e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_149dd4825d290939249ef96dc8b3781f |
| publicationDate | 2011-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-079135-A1 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF {4,6-DIAMINO-2- [1- (2-FLUOROBENCIL) -1H-PIRAZOLO [3,4-B] PIRIDIN-3-IL] PIRIMIDIN-5-IL} CARBAMATO DE METTILO AND ITS PURIFICATION FOR USE AS A PHARMACEUTICAL ACTIVE PRINCIPLE |
| abstract | Claim 1: Process for the preparation of {4,6-diamino-2- [1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridin-3-yl] pyrimidin-5-yl} carbamate methyl of formula (1), characterized in that 2- [1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridin-3-yl] -5 - [(E) -phenyldiazenil] pyrimidin is cleaved -4,6-diamine of formula (2) by catalytic hydrogenation and 2- [1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridin-3-yl] -4,5 is isolated, 6-pyrimidintriamine of formula (3) without intermediate salt formation. Claim 3: Process for the purification of {4,6-diamino-2- [1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridin-3-yl] pyrimidin-5-yl} carbamate methyl of formula (1), characterized in that the crude product of the compound of formula (1) is dissolved in dimethylsulfoxide and the {4,6-diamino-2- [1- (2-fluorobenzyl) -1H-pyrazolo [3 , 4-b] pyridin-3-yl] pyrimidin-5-yl} dimethyl sulfinyldimethane carbamate (1: 2) obtained in this regard and then dimethylsulfoxide is separated by drying in a pharmaceutically acceptable solvent. Claim 6: Use of methyl {4,6-diamino-2- [1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridin-3-yl] pyrimidin-5-yl} carbamate of formula (1), which can be obtained by the method and / or purification according to one of claims 1 to 3, for the preparation of a medicament for the treatment of cardiovascular diseases and erectile dysfunction. |
| priorityDate | 2009-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.