http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-078884-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eb7ce8745175865c6357f7d5fe7fccf5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 |
| filingDate | 2010-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-078884-A1 |
| titleOfInvention | INDTH-BASED CRTH2 RECEIVER ANTAGONISTS |
| abstract | As antagonists of CRTH2 receptors. Pharmaceutical compositions containing compounds of Formula (1) and the use of compounds of Formula (1) to treat diseases or disorders that are sensitive to inhibition of binding of endogenous ligands to the CRTH2 receptor are also disclosed. Claim 1: A compound of Formula (1): or a pharmaceutically acceptable salt thereof; in which: - - - - - is a single link or a double link or is absent; each of R1 and R2 is independently H, halogen, OR6, SO2R7, NR8R9, or alkyl; wherein R6 is H or alkyl; R7 is alkyl; each of R8 and R9 is independently H, COCH3 or alkyl; R3 is hydroxy, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl, wherein each alkyl, alkenyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl is optionally substituted with Ra; where Ra is alkyl, aryl, heteroaryl, cycloalkyl, alkoxy, phenoxy, halogen, hydroxy, amino, mono- or di-alkylamino, nitro, haloalkyl, haloalkoxy, halophenoxy, CO, carboxamide, sulfonamide or SO2Me, in which each alkyl, aryl , heteroaryl is optionally further substituted with H, alkyl, aryl, alkoxy, phenoxy, halogen, hydroxy, haloalkyl, haloalkoxy, halophenoxy or SO2Me; R4 is H or alkyl; R5 is CR10R11COOR12, CR10R11CR13NR14R15, COR17, CR10R11CN, CR10R11CR19; in which each of R10 and R11 is independently H or alkyl; R is H or alkyl; R13 is O; each of R14 and R15 is independently H, COCH3, SO2R16, alkyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl; wherein R16 is H, alkyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl; R17 is alkyl, aryl, heteroaryl, each of which is optionally substituted with -OH or OR18; in which R18 is alkyl; R19 is alkyl; aryl, heteroaryl or alkyl optionally substituted with -OH; X is CH or N; and n is 0 or 1. |
| priorityDate | 2009-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.