http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-078550-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b8726f713a6d86892687edccfa03d886 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 |
| filingDate | 2010-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-078550-A1 |
| titleOfInvention | DERIVATIVES OF AZETIDINE AND PIPERIDINE, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM AND THEIR USE FOR THE TREATMENT OF AFFECTIONS MEDIATED BY THE MODULATION OF GPR119 |
| abstract | Heterocyclic compounds, pharmaceutical compositions comprising these compounds, and the use of such compounds, in order to treat or prevent the diseases or disorders associated with the activity of GPR119. Claim 1: A compound selected from formula (1), wherein: n is selected from 0, 1, 2, 3 and 4; R1 is selected from -X1S (O) 0-2X2R4a, -X1C (O) OX2R4a, -X1C (O) X2R4a, X1S (O) 0-2X2OR4a, -X1C (O) NR4bX2R4a, -X1S (O) 0 -2X2C (O) R4a, -X1S (O) 0-2X2C (O) OR4a, -X1S (O) 0-2X2OC (O) R4a and -X1S (O) 0-2NR4aR4b; wherein X1 is selected from a bond, O, NR5aR5b and C1-4 alkylene; X2 is selected from a bond and C1-4 alkylene; R4a is selected from hydrogen, halogen, hydroxyl, C1-6 alkyl, C1-6 alkyl substituted by halogen, C1-6 alkyl substituted by hydroxyl, C2-6 alkenyl, C6-10 aryl, heteroaryl, C3-8 heterocycloalkyl, and C3-8 cycloalkyl; wherein this aryl, heteroaryl, cycloalkyl and heterocycloalkyl of R4a is optionally substituted with 1 to 3 radicals independently selected from hydroxyl, halogen, C1-6 alkyl, C1-6 alkyl substituted by halogen, C1-6 alkyl substituted by hydroxyl, C1-6 alkyl substituted by cyano, C1-6 alkoxy, C1-6 alkoxy substituted by halogen, C6-10 aryl-C1-4 alkoxy, and -X3C (O) OX4R5c; wherein R4b is selected from hydrogen and C1-6 alkyl; and R5a and R5b are independently selected from hydrogen and C1-6 alkyl; wherein X3 and X4 are independently selected from a bond and C1-4 alkylene; R5c is selected from hydrogen and C1-6 alkyl; R2 is independently selected from hydrogen, halogen, hydroxyl, C1-6 alkyl, C1-6 alkyl substituted by halogen, C1-6 alkyl substituted by hydroxyl, C1-6 alkoxy, C1-6 alkoxy substituted by halogen, -C ( O) R6, and -C (O) OR6; wherein R6 is selected from hydrogen and C1-6 alkyl; R20 is selected from hydrogen and methyl; W1 and W2 are independently selected from CR7 and N; wherein R7 is selected from hydrogen, halogen, cyano, C1-6 alkyl, and -C (O) OR8; wherein R8 is selected from hydrogen and C1-6 alkyl; Y1 is selected from CH2 and C (O); or Y1 and W2 taken together can form a double bond, where W2 is C, and Y1 is CH; Y2, Y3, Y6 and Y7 are independently selected from N and CR9, where at least two of Y2, Y3, Y6 and Y7 are CR9 where R9 is selected from hydrogen, halogen, hydroxyl, C1-6 alkyl , C1-6 alkyl substituted by halogen, C1-6 alkyl substituted by hydroxyl, C1-6 alkoxy, C1-6 alkoxy substituted by halogen, -C (O) R10, and -C (O) OR10; wherein R10 is selected from hydrogen and C1-6 alkyl; Y4 is selected from O, CR11aR11b, NR11a and S (O) 0-2; each R11a and R11b is independently selected from hydrogen and C1-6 alkyl; wherein the alkyl of R11a or R11b is optionally substituted with hydroxyl, C1-4 alkyl, halogen, C1-4 alkyl substituted by halogen, C1-4 alkoxy, C1-4 alkoxy substituted by halogen, and -NR12aR12b; wherein R12a and R12b are independently selected from hydrogen and C1-4 alkyl; Y5 is selected from (CR13aR13b) 1-3; wherein R13a and R13b are independently selected from hydrogen, halogen, and C1-6 alkyl; wherein the alkyl of R13a or R13b is optionally substituted with 1 to 5 substituents independently selected from hydroxyl, C1-4 alkyl, halogen, C1-4 alkyl substituted by halogen, C1-4 alkoxy, and C1-4 alkoxy substituted by halogen; or R13a and R3, together with the atoms with which they are attached, form oxetan-3-yl; R3 is selected from C6-10 aryl, and heteroaryl; wherein this aryl or heteroaryl of R3 is optionally substituted with 1 to 4 radicals R14; wherein each R14 is independently selected from hydrogen, C1-6 alkyl, halogen, cyano, C1-6 alkoxy, halogen substituted C1-6 alkyl, halogen substituted C1-6 alkoxy, C3-8 cycloalkyl and C1- heterocycloalkyl 10; wherein the alkyl, cycloalkyl, heterocycloalkyl and alkoxy of R14 is optionally substituted by 1 to 3 groups selected from C1-6 alkyl, halogen, C1-6 alkoxy, halogen substituted C1-6 alkyl, and substituted C1-6 alkoxy by halogen; and pharmaceutically acceptable salts thereof. |
| priorityDate | 2009-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.